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Structural Abnormalities are Similar in Familial and Nonfamilial Mesial Temporal Lobe Epilepsy

Published online by Cambridge University Press:  02 December 2014

Fabio Thadeu Ferreira ,
Eliane Kobayashi ,
Iscia Lopes-Cendes  and
Fernando Cendes
Fabio Thadeu Ferreira
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Eliane Kobayashi
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Iscia Lopes-Cendes
Affiliation:
Department of Medical Genetics, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Fernando Cendes
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
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Abstract

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Background/Objective:

Diffuse temporal lobe abnormalities can be observed on MRI of patients with mesial temporal lobe epilepsy (MTLE). Our objective was to perform qualitative and quantitative analyses of temporal lobe structures in patients with familial MTLE (FMTLE) and nonfamilial MTLE.

Methods:

Two groups of patients were ascertained: 67 FMTLE patients (14 with refractory seizures) and 30 patients with nonfamilial refractory MTLE. We performed qualitative analyses of MRI (with multiplanar reconstruction) and volumes of hippocampi and anterior temporal lobes in all patients, and in a normal control group of 23 individuals. We used the Chi-square test and ANOVA for statistical analyses.

Results:

We identified anterior temporal lobe abnormalities by visual analysis in only 4% of FMTLE patients and atrophy of the anterior temporal lobe by volumetric analysis in 19%. In the group of nonfamilial MTLE patients we found anterior temporal lobe abnormalities by visual analysis in 17% of patients and anterior temporal lobe atrophy in 13%. Hippocampal atrophy was present in 90% of FMTLE and in 83% of nonfamilial MTLE. No signs of cortical dysplasia were observed.

Conclusion:

Anterior temporal lobe atrophy and other abnormalities outside the mesial portion of temporal lobes were infrequent in both familial and nonfamilial MTLE patients. Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 31 , Issue 3 , August 2004 , pp. 368 - 372
Copyright
Copyright © The Canadian Journal of Neurological 2004

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