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Blood sulfur-amino acid concentration reflects an impairment of liver transsulfuration pathway in patients with acute abdominal inflammatory processes

Published online by Cambridge University Press:  09 March 2007

Juan R. Viñ ,
Angel Giménez ,
Adelina Corbacho ,
Inmaculada R. Puertes ,
Elisa Borrás ,
Concha García  and
Teresa Barber
Juan R. Viñ*
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
Angel Giménez
Affiliation:
Hospital de la Ribera, Alzira, Valencia, Spain
Adelina Corbacho
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
Inmaculada R. Puertes
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
Elisa Borrás
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
Concha García
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
Teresa Barber
Affiliation:
Dpto Bioquímica y Biología Molecular, Facultades de Medicina y Farmacia, Universidad de Valencia, Spain
*
*Corresponding author: Dr Juan R. Viña fax + 34 6 3864173, email: Juan.R.Vina@UV.es
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Abstract

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Whole-blood free amino acids were measured in a control group made up of eight healthy women fasted for 12 h and also in eight patients with acute pancreatitis, five patients with acute cholecystitis and seven patients with acute appendicitis. Blood was withdrawn immediately on admission to hospital and again 3 d later following a controlled peripheral parenteral nutrition diet; this is with the exception of the appendicitis group. L-CYSTATHIONINE AND l-methionine concentrations were significantly higher in pancreatitis and appendicitis patients when compared with controls. In the pancreatitis and cholecystitis patients, l-serine concentration was also significantly higher when compared with controls. The l-homocysteine concentration was significantly higher only in the appendicitis group when compared with the control group. l-Cystine concentration was unchanged in all the patients studied when compared with control subjects. The l-methionine : l-cystine ratio was significantly higher and the l-glutamine : l-cystine ratio was significantly lower in all the patients when compared with controls. The blood S-amino acid pattern reflects an impairment in liver transsulfuration pathway during acute abdominal processes. This work supports the idea that the l-methionine : l-cystine and l-glutamine : l-cystine ratios can be taken as good markers to evaluate the S-amino acid metabolism and suggests the importance of using N-acetylcysteine as a required nutrient in these situations.

Keywords

l-Methioninel-Cystineα-Cystathionase
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 2 , February 2001 , pp. 173 - 178
Copyright
Copyright © The Nutrition Society 2001

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