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Abnormalities of cortical structures in adolescent-onset conduct disorder

Published online by Cambridge University Press:  20 July 2015

Y. Jiang ,
X. Guo ,
J. Zhang ,
J. Gao ,
X. Wang ,
W. Situ ,
J. Yi ,
X. Zhang ,
X. Zhu  and
S. Yao
...Show all authors
Y. Jiang
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
X. Guo
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
J. Zhang
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
J. Gao
Affiliation:
Centre of Buddhist Studies, University of Hong Kong, Hong Kong, People's Republic of China Biomedical Engineering Laboratory, Department of Electronic Electrical Engineering, University of Hong Kong, Hong Kong, People's Republic of China Alzheimer's Disease Research Network, Strategic Research Theme of Healthy Aging, University of Hong Kong, Hong Kong, People's Republic of China
X. Wang
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
W. Situ
Affiliation:
Department of Radiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
J. Yi
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
X. Zhang
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
X. Zhu
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China National Technology Institute of Psychiatry, Central South University, Changsha, Hunan, People's Republic of China Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People's Republic of China
S. Yao*
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China National Technology Institute of Psychiatry, Central South University, Changsha, Hunan, People's Republic of China Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People's Republic of China
B. Huang*
Affiliation:
Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, People's Republic of China Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, Guangdong, People's Republic of China
*
*Addresses for correspondence: S. Yao, Medical Psychological Institute, the Second Xiangya Hospital of Central South University, no. 139, Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China; B. Huang, Department of Biomedical Engineering, School of Medicine, Shenzhen University, no. 3688, Nanhai Avenue, Shenzhen, Guangdong 518060, People's Republic of China. (Email: shuqiaoyao@163.com) [S.Y.] (Email: huangbs@gmail.com) [B.H.]
*Addresses for correspondence: S. Yao, Medical Psychological Institute, the Second Xiangya Hospital of Central South University, no. 139, Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China; B. Huang, Department of Biomedical Engineering, School of Medicine, Shenzhen University, no. 3688, Nanhai Avenue, Shenzhen, Guangdong 518060, People's Republic of China. (Email: shuqiaoyao@163.com) [S.Y.] (Email: huangbs@gmail.com) [B.H.]
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Abstract

Background.

Converging evidence has revealed both functional and structural abnormalities in adolescents with early-onset conduct disorder (EO-CD). The neurological abnormalities underlying EO-CD may be different from that of adolescent-onset conduct disorder (AO-CD) patients. However, the cortical structure in AO-CD patients remains largely unknown. The aim of the present study was to investigate the cortical alterations in AO-CD patients.

Method.

We investigated T1-weighted brain images from AO-CD patients and age-, gender- and intelligence quotient-matched controls. Cortical structures including thickness, folding and surface area were measured using the surface-based morphometric method. Furthermore, we assessed impulsivity and antisocial symptoms using the Barratt Impulsiveness Scale (BIS) and the Antisocial Process Screening Device (APSD).

Results.

Compared with the controls, we found significant cortical thinning in the paralimbic system in AO-CD patients. For the first time, we observed cortical thinning in the precuneus/posterior cingulate cortex (PCC) in AO-CD patients which has not been reported in EO-CD patients. Prominent folding abnormalities were found in the paralimbic structures and frontal cortex while diminished surface areas were shown in the precentral and inferior temporal cortex. Furthermore, cortical thickness of the paralimbic structures was found to be negatively correlated with impulsivity and antisocial behaviors measured by the BIS and APSD, respectively.

Conclusions.

The present study indicates that AO-CD is characterized by cortical structural abnormalities in the paralimbic system, and, in particular, we highlight the potential role of deficient structures including the precuneus and PCC in the etiology of AO-CD.

Keywords

Brain structureconduct disordercortical thicknessneuroimagingsurface-based morphometry
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 16 , December 2015 , pp. 3467 - 3479
Copyright
Copyright © Cambridge University Press 2015 

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