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How do different surface modification strategies affect the properties of MnO nanoparticles for biomedical applications? Comparison of PEGylated and SiO2-coated MnO nanoparticles

Published online by Cambridge University Press:  03 August 2011

Thomas D. Schladt ,
Kerstin Koll ,
Heiko Bauer ,
Stefan Weber ,
Laura M. Schreiber  and
Wolfgang Tremel
Thomas D. Schladt
Affiliation:
IBM Almaden Research Center, San Jose, CA 95120-6099, U.S.A. Institut für Anorganische und Analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, D-55099 Mainz, Germany Graduate School Materials Science in Mainz, Staudinger Weg 9, D-55128 Mainz, Germay
Kerstin Koll
Affiliation:
Institut für Anorganische und Analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, D-55099 Mainz, Germany Graduate School Materials Science in Mainz, Staudinger Weg 9, D-55128 Mainz, Germay
Heiko Bauer
Affiliation:
Institut für Anorganische und Analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, D-55099 Mainz, Germany
Stefan Weber
Affiliation:
Institut für medizinische Physik, Klinik und Poliklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Langenbeckstrasse 1, D-55131 Mainz, Germany
Laura M. Schreiber
Affiliation:
Institut für medizinische Physik, Klinik und Poliklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Langenbeckstrasse 1, D-55131 Mainz, Germany
Wolfgang Tremel
Affiliation:
Institut für Anorganische und Analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, D-55099 Mainz, Germany
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Abstract

MnO nanoparticles (NPs) were surface functionalized by two different approaches, (1) using a dopamine-poly(ethylene glycol) (PEG) (DA-PEG) ligand and (2) by encapsulation within a thin silica shell applying a novel approach. Both MnO@DA-PEG and MnO@SiO2 NPs exhibited excellent long-term stability in physiological solutions. In addition, the cytotoxic potential of both materials was comparatively low. Furthermore, owing to the magnetic properties of MnO NPs, both MnO@DA-PEG and MnO@SiO2 lead to a shortening of the longitudinal relaxation time T1 in MRI. In comparison to the PEGylated MnO NPs, the presence of a thin silica shell led to a greater stability of the MnO core itself by preventing excessive Mn ion leaching into aqueous solution.

Keywords

biomedicalcore/shellsurface chemistry
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1355: Symposium JJ – Biological Hybrid Materials for Life Sciences , 2011 , mrss11-1355-jj06-06
Copyright
Copyright © Materials Research Society 2011

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References

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