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Fine needle aspiration in the pre-operative diagnosis of melanotic neuroectodermal tumour of infancy

Published online by Cambridge University Press:  29 June 2007

H. Galera-Ruiz ,
D. Gomez-Angel ,
F. J. Vazquez-Ramirez ,
J. C. Sanguino-Fabre ,
C. I. Salazar-Fernandez  and
J. Gonzalez-Hachero
H. Galera-Ruiz*
Affiliation:
Otolaryngology – Head and Neck Surgery Service, University of Seville, School of Medicine, Seville, Spain.
D. Gomez-Angel
Affiliation:
Otolaryngology – Head and Neck Surgery Service, University of Seville, School of Medicine, Seville, Spain.
F. J. Vazquez-Ramirez
Affiliation:
Department of Pathology, University of Seville, School of Medicine, Seville, Spain.
J. C. Sanguino-Fabre
Affiliation:
Department of Pediatrics, University of Seville, School of Medicine, Seville, Spain.
C. I. Salazar-Fernandez
Affiliation:
Oral Maxillofacial Surgery Service, University of Seville, School of Medicine, Seville, Spain.
J. Gonzalez-Hachero
Affiliation:
Department of Pediatrics, University of Seville, School of Medicine, Seville, Spain.
*
Address for correspondence: Dr Hugo Galera-Ruiz, Avda. Cañada de la viña n°75, 41927 Mairena del Aljarafe, Sevilla Spain. Fax: 34-5-4371284
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Abstract

A case of melanotic neuroectodermal tumour of infancy is decribed. The pre-operative diagnosis was made on cytological material obtained by fine needle aspiration. The patient was a three-month-old male infant with a rapidly growing maxillary tumour mass that also involved the pterygomaxillary fossae and the floor of the orbit. In addition to the typical clinical presentation, the cytology is also distinctive showing a dual population of small neuroblastic cells and large melanin-containing epithelial cells. Histological, immunohistochemical and electron microscopic examination of the excised mass confirmed the initial diagnosis. The pre-operative distinction of this tumour from other small round cell tumours of infancy (rhabdomyosarcoma, neuroblastoma, melanoma and lymphoma), is essential in order to plan the most complete resection therefore reducing the possibilities of tumour recurrence. This tumour belongs to a field of pathology with which many otolaryngologists may not be familiar.

Keywords

Maxillary neoplasmsCytodiagnosisImmunohistochemistry
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 6 , June 1999 , pp. 581 - 584
Copyright
Copyright © JLO (1984) Limited 1999

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