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Urinary incontinence and diarrhoea associated with the switch from oral to injectable risperidone

Published online by Cambridge University Press:  21 February 2013

Enrica Di Rosa ,
Daniela Caldirola ,
Achille Motta  and
Giampaolo Perna
Enrica Di Rosa*
Affiliation:
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy Department of Clinical Neuroscience, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, Italy
Daniela Caldirola
Affiliation:
Department of Clinical Neuroscience, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, Italy
Achille Motta
Affiliation:
Department of Clinical Neuroscience, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, Italy
Giampaolo Perna
Affiliation:
Department of Clinical Neuroscience, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, Italy Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
*
Enrica Di Rosa, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Policlinico Universitario, via Consolare Valeria, Messina 198125, Italy. Tel: +00393333992601; Fax: +0039090695136; E‐mail: edirosa@unime.it, enricadirosa@tiscali.it
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Abstract

Objective

Urgency, urinary incontinence and bowel disturbances are distressing side effects that have been observed during treatment with risperidone and other antipsychotics probably due to the receptor affinity profile. This occurrence can lead to poor compliance and therefore impair clinical outcome.

Method

We report the case of a 50 year‐old lady, who experienced urinary incontinence and diarrhoea, when switching from oral to injectable risperidone, which ceased when discontinuing the drug.

Results and conclusions

It should be taken into account that some side effects can be revealed when switching from oral to depot formulations due to non‐compliance to orals; nevertheless dose‐dependent mechanisms and individual metabolic variability must be considered when observing idiosyncratic reactions to drugs.

Keywords

atypical antipsychoticsinjectable resperidoneneuroleptic side effectspsychopharmacologyurinary incontinence
Type
Case Report
Information
Acta Neuropsychiatrica , Volume 25 , Issue 2 , April 2013 , pp. 119 - 121
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013

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