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Sex difference in counts of α4 and α7 nicotinic acetylcholine receptors in the nasal polyps of adults with or without exposure to tobacco smoke

Published online by Cambridge University Press:  11 June 2018

B B Montaño-Velázquez
Affiliation:
Otorhinolaryngology Service, Hospital General del Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico
D A Lara-Sánchez
Affiliation:
Otorhinolaryngology Service, Hospital General del Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico
A Orozco-Sánchez
Affiliation:
Otorhinolaryngology Service, Hospital General del Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico
F J García-Vázquez
Affiliation:
Department of Anatomical Pathology, Instituto Nacional de Pediatría, Mexico City, Mexico
M R Mora-Campos
Affiliation:
Anatomical Pathology Service, Hospital de Especialidades del Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico
K Jáuregui-Renaud*
Affiliation:
Medical Research Unit in Otoneurology, Instituto Mexicano del Seguro Social, Mexico City, Mexico
*
Address for correspondence: Dr Kathrine Jáuregui-Renaud, Unidad de Investigación Médica en Otoneurología, PB Edificio C Salud en el Trabajo, Centro Médico Nacional sXXI, IMSS, Av. Cuauhtémoc 330, Colonia Doctores, CP 06720, Ciudad de México, México E-mail: kathrine.jauregui@imss.gob.mx

Abstract

Objective

To assess counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults with or without long-term exposure to cigarette tobacco smoke.

Methods

Twenty-two patients with and 22 patients without exposure to cigarette tobacco smoke participated in the study. After endoscopic polypectomy, the fragments of the nasal polyps were analysed by immunohistochemistry.

Results

Compared to patients with no exposure, patients with exposure showed higher counts of α4 and α7 nicotinic acetylcholine receptors (t-test, p < 0.05). However, in patients with no exposure, multivariate analysis showed gender dimorphism, with lower counts in males than in females, and no influence from other variables (analysis of covariance, p > 0.05).

Conclusion

Exposure to cigarette tobacco smoke may induce increased counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults, with lower counts in males than females without exposure to tobacco smoke.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr K Jáuregui-Renaud takes responsibility for the integrity of the content of the paper

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