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Diet-related variation in cellular retinol-binding protein type II gene expression in rat jejunum

Published online by Cambridge University Press:  08 March 2007

Kazuhito Suruga ,
Masaaki Kitagawa ,
Hiromitsu Yasutake ,
Sachiko Takase  and
Toshinao Goda
Kazuhito Suruga
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st century, University of Shizuoka School of Food and Nutritional Sciences, Shizuoka 422-8526, Japan
Masaaki Kitagawa
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st century, University of Shizuoka School of Food and Nutritional Sciences, Shizuoka 422-8526, Japan
Hiromitsu Yasutake
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st century, University of Shizuoka School of Food and Nutritional Sciences, Shizuoka 422-8526, Japan
Sachiko Takase
Affiliation:
Department of Nutrition, Siebold University of Nagasaki, Nagasaki 851-1200, Japan
Toshinao Goda*
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st century, University of Shizuoka School of Food and Nutritional Sciences, Shizuoka 422-8526, Japan
*
*Corresponding author: Dr Toshinao Goda, fax +81 54 264 5565, email gouda@fns1.u-shizuoka-ken.ac.jp
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Abstract

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Cellular retinol-binding protein type II (CRBPII) is involved in the transport of vitamin A and its metabolism in the small intestine. In the present study, we demonstrated diet-related variations in CRBPII expression in rat jejunum. The CRBPII protein and mRNA levels increased in parallel after the start of feeding period regardless of whether the feeding period was restricted to the hours of darkness or of light. In addition, this variation was observed in the rats fed high-fat diet or low-fat diets, but not in those fed a fat-free diet or in fasted rats. A similar diet-induced variation was seen in the mRNA of liver-type fatty acid-binding protein in rat jejunum. In the transient transfection experiment, unsaturated fatty acid increased rat CRBPII gene promoter activity via the PPARα/retinoid X receptor-α heterodimer. Taken together, these results suggest that the diet-related variation in CRBPII expression in rat jejunum may be brought about by the transcriptional induction of CRBPII gene expression mainly triggered by dietary fatty acids.

Keywords

CRBPIIL-FABPsmall intestinePPARdietary fat
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 6 , December 2005 , pp. 890 - 895
Copyright
Copyright © The Nutrition Society 2005

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