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The pathogenesis of benzimidazole-resistant and benizimidazole-susceptible strains of trichostrongylus colubriformis in the Mongolian gerbil (Meriones unguiculatus)

Published online by Cambridge University Press:  05 June 2009

John M. Maclean
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.
David lewis
Affiliation:
Pfizer Central Research, Sandwich, Kent, England, U.K.
Peter H. Holmes
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.

Abstract

Mongolian gerbils were infected with either a benzimidazole-susceptible or a benzimidazole-resistant strain of Trichostrongylus colubriformis larvae. The comparative pathogensis of both strains of T. colubriformis was investigated for 50 days post-infection. The gerbils infected with the drug-susceptible strain of the parasite showed lower survival rates, reduced body weights, higher parasite egg output and higher worm burdens than animals intected with the drug-resistant stram of parasite. There was also evidence of an enhanced hypoalbuminaemia and a more marked gastrointestinal plasma leak in the gerbils infected with the drug-susceptible strain of patasite. Scanning electron microscope examination of the small intestine showed signs of villus atriphy in both groups of ingected grebils.

Type
Research Papers
Copyright
Copyright © Cambridge University Press 1987

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