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Strategies for optimizing medication adherence in schizophrenia

Published online by Cambridge University Press:  26 April 2012

Debbi A. Morrissette  and
Andrew J. Cutler
Debbi A. Morrissette
Affiliation:
Neuroscience Education Institute, Carlsbad, California, USA
Andrew J. Cutler*
Affiliation:
Florida Clinical Research Center, LLC, Bradenton, Florida, USA
*
*Address correspondence to: Andrew J. Cutler, Courtesy Assistant Professor, Department of Psychiatry, University of Florida, CEO and Chief Medical Officer, Florida Clinical Research Center, LLC, 8043 Cooper Creek Blvd., Suite 107, Bradenton, Florida 34201, USA. Email: acutler@flcrc.com
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Abstract

Medication nonadherence is a common problem in the treatment of schizophrenia. The consequences of nonadherence are numerous and can be quite serious, including increased risk of rehospitalization and suicide. There are numerous factors that affect a patient's decision and ability to take medication, including medication efficacy and tolerability, treatment regimen, cognitive deficits, and the patient's relationship with the treatment team. Fortunately, there are several strategies that may increase treatment adherence, including individualization of medication selection and dosing strategy to maximize efficacy and minimize adverse side effects, utilization of long-acting injectable depot formulations that eliminate the need for the patient to remember daily oral medication, and psychosocial approaches that emphasize the benefits of staying well.

Keywords

atypical antipsychoticscognitive deficitslong-acting depotpsychosocialside effects
Type
CME Article
Information
CNS Spectrums , Volume 17 , Issue 1 , 26 April 2012 , pp. 31 - 41
Copyright
Copyright © Cambridge University Press 2012

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