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Polymeric/Inorganic Multifunctional Nanoparticles for Simultaneous Drug Delivery and Visualization

Published online by Cambridge University Press:  01 February 2011

Andrea Fornara ,
Alberto Recalenda ,
Jian Qin ,
Abhilash Sugunan ,
Fei Ye ,
Sophie Laurent ,
Robert N Muller ,
Jing Zou ,
Abo-Ramadan Usama  and
Muhammet S Toprak
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Andrea Fornara
Affiliation:
fornara@kth.se, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Alberto Recalenda
Affiliation:
alberto.recalenda@gmail.com, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Jian Qin
Affiliation:
jianq@kth.se, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Abhilash Sugunan
Affiliation:
abhilash@kth.se, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Fei Ye
Affiliation:
feiy@kth.se, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Sophie Laurent
Affiliation:
Sophie.Laurent@umons.ac.be, University of Mons, Department of General, Organic and Biomedical Chemistry, Mons, Belgium
Robert N Muller
Affiliation:
Robert.Muller@umons.ac.be, University of Mons, Department of General, Organic and Biomedical Chemistry, Mons, Belgium
Jing Zou
Affiliation:
Jing.Zou@uta.fi, University of Tampere, Department of Otolaryngology, Tampere, Finland
Abo-Ramadan Usama
Affiliation:
usama.abo-ramadan@hus.fi, Biomedicum, Experimental MRI Laboratory, Helsinki, Finland
Muhammet S Toprak
Affiliation:
toprak@kth.semuhammet.toprak@gmail.com, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
Mamoun Muhammed
Affiliation:
mamoun@kth.se, Royal Institute of Technology, Functional Materials Division, Stockholm, Sweden
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Abstract

Nanoparticles consisting of different biocompatible materials are attracting a lot of interest in the biomedical area as useful tools for drug delivery, photo-therapy and contrast enhancement agents in MRI, fluorescence and confocal microscopy. This work mainly focuses on the synthesis of polymeric/inorganic multifunctional nanoparticles (PIMN) based on biocompatible di-block copolymer poly(L,L-lactide-co-ethylene glycol) (PLLA-PEG) via an emulsion-evaporation method. Besides containing a hydrophobic drug (Indomethacin), these polymeric nanoparticles incorporate different visualization agents such as superparamagnetic iron oxide nanoparticles (SPION) and fluorescent Quantum Dots (QDs) that are used as contrast agents for Magnetic Resonance Imaging (MRI) and fluorescence microscopy together. Gold Nanorods are also incorporated in such nanostructures to allow simultaneous visualization and photodynamic therapy. MRI studies are performed with different loading of SPION into PIMN, showing an enhancement in T2 contrast superior to commercial contrast agents. Core-shell QDs absorption and emission spectra are recorded before and after their loading into PIMN. With these polymeric/inorganic multifunctional nanoparticles, both MRI visualization and confocal fluorescence microscopy studies can be performed. Gold nanorods are also synthesized and incorporated into PIMN without changing their longitudinal absorption peak usable for lased excitation and phototherapy. In-vitro cytotoxicity studies have also been performed to confirm the low cytotoxicity of PIMN for further in-vivo studies.

Keywords

polymerbiomedicalnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1257: Symposium O – Multifunctional Nanoparticle Systems-Coupled Behavior and Applications , 2010 , 1257-O04-03
Copyright
Copyright © Materials Research Society 2010

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