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Patterned Polymer Nanofibers Based Biosensors

Published online by Cambridge University Press:  22 June 2011

Timothy O. Mertz ,
Vindhya Kunduru ,
Prabir K. Patra ,
Krishna Vattipalli  and
Shalini Prasad
Timothy O. Mertz
Affiliation:
Department of Electrical Engineering and Computer Science, Wichita State University, Wichita, KS 67260, U.S.A.
Vindhya Kunduru
Affiliation:
Biomedical Engineering Department, North Carolina State University, Raleigh, North Carolina 27694, U.S.A.
Prabir K. Patra
Affiliation:
Department of Mechanical Engineering, School of Engineering, University of Bridgeport, Bridgeport, Connecticut 06604, U.S.A.
Krishna Vattipalli
Affiliation:
Department of Electrical Engineering and Computer Science, Wichita State University, Wichita, KS 67260, U.S.A.
Shalini Prasad
Affiliation:
Department of Electrical Engineering and Computer Science, Wichita State University, Wichita, KS 67260, U.S.A.
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Abstract

“Label-free” biomolecule sensors for detection of inflammatory cardiovascular biomarker associated with vulnerable coronary vascular plaque were designed and fabricated using micro and nano-textured polystyrene structures that functioned as sensing elements coupled with electronic measurement equipment. We demonstrated that scaling down the surface texturing from the micro to the nanoscale enhances the amplitude of the measured signal strength. We believe that the nanoscale fiber morphology provides size matched spaces for trapping and immobilizing the protein biomolecules resulting in enhanced detection and signal strength. We selected polystyrene as the model system and demonstrated the detection of human serum C-reactive protein (hs-CRP). We employed these findings in designing a platform “lab-on-a-chip” protein sensor. Comparative studies were performed on two different polystyrene textured surfaces: a polystyrene microsphere mat, and an electrospun polystyrene nanofiber matrix.

Keywords

polymersensornanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1358: Symposium MM – Organic Bioelectronics and Photonics for Sensing and Regulation , 2011 , mrss11-1358-mm03-07
Copyright
Copyright © Materials Research Society 2011

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References

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