Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-23T05:28:59.269Z Has data issue: false hasContentIssue false

Cognitive rehabilitation for early stage Alzheimer’s disease: a pilot study with an Irish population

Published online by Cambridge University Press:  03 July 2017

M. E. Kelly*
Affiliation:
Department of Psychology, John Hume Building, Maynooth University, Co. Kildare, Ireland
B. A. Lawlor
Affiliation:
Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
R. F. Coen
Affiliation:
Mercer’s Institute for Successful Ageing, Clinical Research Facility, St. James Hospital, Dublin, Ireland
I. H. Robertson
Affiliation:
Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
S. Brennan
Affiliation:
Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
*
*Address for correspondence: M. E. Kelly, Department of Psychology, Room SF21, 2nd Floor John Hume Building, North Campus, Maynooth University, Co. Kildare, Ireland (Email: Michelle.E.Kelly@nuim.ie)

Abstract

Objectives

Research shows that cognitive rehabilitation (CR) has the potential to improve goal performance and enhance well-being for people with early stage Alzheimer’s disease (AD). This single subject, multiple baseline design (MBD) research investigated the clinical efficacy of an 8-week individualised CR intervention for individuals with early stage AD.

Methods

Three participants with early stage AD were recruited to take part in the study. The intervention consisted of eight sessions of 60–90 minutes of CR. Outcomes included goal performance and satisfaction, quality of life, cognitive and everyday functioning, mood, and memory self-efficacy for participants with AD; and carer burden, general mental health, quality of life, and mood of carers.

Results

Visual analysis of MBD data demonstrated a functional relationship between CR and improvements in participants’ goal performance. Subjective ratings of goal performance and satisfaction increased from baseline to post-test for three participants and were maintained at follow-up for two. Baseline to post-test quality of life scores improved for three participants, whereas cognitive function and memory self-efficacy scores improved for two.

Conclusions

Our findings demonstrate that CR can improve goal performance, and is a socially acceptable intervention that can be implemented by practitioners with assistance from carers between sessions. This study represents one of the promising first step towards filling a practice gap in this area. Further research and randomised-controlled trials are required.

Type
Original Research
Copyright
© College of Psychiatrists of Ireland 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baddeley, A, Wilson, BA (1994). When implicit learning fails: amnesia and the problem of error elimination. Neuropsychologia 32, 5368.Google Scholar
Bahar-Fuchs, A, Clare, L, Woods, B (2013). Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer’s or vascular type: a review. Alzheimer’s Research & Therapy 5, 35.CrossRefGoogle ScholarPubMed
Barnes-Holmes, D, Barnes-Holmes, Y, Stewart, I, Boles, S (2010). A sketch of the implicit relational assessment procedure (IRAP) and the relational elaboration and coherence (REC) model. The Psychological Record 60, 527542.CrossRefGoogle ScholarPubMed
Bonomi, AE, Patrick, DL, Bushnell, DM, Martin, M (2000). Validation of the United States’ version of the World Health Organization Quality of Life (WHOQOL) instrument. Journal of Clinical Epidemiology 53, 112.CrossRefGoogle Scholar
Clare, L (2008). Neuropsychological Rehabilitation: A Modular Handbook. Psychology Press: New York.CrossRefGoogle ScholarPubMed
Clare, L (2010). Cognitive rehabilitation and people with dementia. In J. H. Stone & M. Blouin (Eds.). International Encyclopedia of Rehabilitation. Buffalo: Center for International Rehabilitation Research Information and Exchange. Retrieved on 14th March 2012 from http://cirrie.buffalo.edu/encyclopedia/en/article/129/.Google Scholar
Clare, L, Bayer, A, Burns, A, Corbett, A, Jones, R, Knapp, M, Kopelman, M, Kudlicka, A, Leroi, I, Oyebode, J, Pool, J, Woods, B, Whitaker, R (2013). Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials 14, 152.Google Scholar
Clare, L, Jones, RS (2008). Errorless learning in the rehabilitation of memory impairment: a critical review. Neuropsychology Review 18, 123.CrossRefGoogle Scholar
Clare, L, Linden, DE, Woods, RT, Whitaker, R, Evans, SJ, Parkinson, CH, van Paasschen, J, Nelis, SM, Hoare, Z, Yuen, KS, Rugg, MD (2010). Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. The American Journal of Geriatric Psychiatry 18, 928939.CrossRefGoogle ScholarPubMed
Clare, L, Wilson, BA (2004). Memory rehabilitation techniques for people with early-stage dementia. Zeitschrift für Gerontopsychologie & Psychiatrie 17, 109117.CrossRefGoogle ScholarPubMed
Clare, L, Wilson, BA, Carter, G, Breen, K, Gosses, A, Hodges, JR (2000). Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. Journal of Clinical and Experimental Neuropsychology 22, 132146.CrossRefGoogle Scholar
Clare, L, Wilson, BA, Carter, G, Hodges, JR (2003). Cognitive rehabilitation as a component of early intervention in Alzheimer’s disease: a single case study. Aging & Mental Health 7, 1521.Google Scholar
Clare, L, Wilson, BA, Carter, G, Roth, I, Hodges, JR (2002). Assessing awareness in early-stage Alzheimer’s disease: development and piloting of the Memory Awareness Rating Scale. Neuropsychological Rehabilitation 12, 341362.CrossRefGoogle ScholarPubMed
Clare, L, Wilson, BA, Carter, G, Roth, I, Hodges, JR (2004). Awareness in early-stage Alzheimer’s disease: relationship to outcome of cognitive rehabilitation. Journal of Clinical and Experimental Neuropsychology 26, 215226.CrossRefGoogle ScholarPubMed
Clare, L, van Paasschen, J, Evans, SJ, Parkinson, C, Woods, RT, Linden, DE (2009). Goal-oriented cognitive rehabilitation for an individual with mild cognitive impairment: behavioural and neuroimaging outcomes. Neurocase 15, 318331.CrossRefGoogle Scholar
Cooper, JO, Heron, TE, Heward, WL (2007). Applied Behavior Analysis, 2nd edn. Pearson: Upper Saddle River, NJ.CrossRefGoogle ScholarPubMed
Dong, Y, Thompson, CL, Huey, S, Tan, J, Swie Lim, LB, Pang, W, Li-Hsian Chen, C (2013). Test-retest reliability, convergent validity and practice effects of the RBANS in a memory clinic setting: a pilot study. Open Journal of Medical Psychology 2, 4B.CrossRefGoogle ScholarPubMed
Dunn, J, Clare, L (2007). Learning face-name associations in early-stage dementia: comparing the effects of errorless learning and effortful processing. Neuropsychological Rehabilitation 17, 735754.Google Scholar
Fernandez-Ballesteros, R, Zamarron, MD, Tarraga, L (2005). Learning potential: a new method for assessing cognitive impairment. International Psychogeriatrics 17, 119128.CrossRefGoogle Scholar
Folstein, MF, Folstein, SE, McHugh, PR (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189198.CrossRefGoogle ScholarPubMed
Gast, DL (2010). Single Subject Research Methodology in Behavioral Sciences. Taylor and Francis: Abingdon, Oxfordshire.CrossRefGoogle ScholarPubMed
Goldberg, D (1992). General Health Questionnaire (GHQ-12). Nfer-Nelson: Windsor.CrossRefGoogle ScholarPubMed
Grady, CL, McIntosh, AR, Beig, S, Keightley, ML, Burian, H, Black, SE (2003). Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer’s disease. The Journal of Neuroscience 23, 986993.Google Scholar
Horner, RH, Carr, EG, Halle, J, McGee, G, Odom, S, Wolery, M (2005). The use of single-subject research to identify evidence-based practice in special education. Exceptional Children 71, 165179.Google Scholar
Johnson-Talbert, C, Cooper, JO (1992). Precision teaching and Alzheimer’s. Journal of Precision Teaching 10, 5372.CrossRefGoogle ScholarPubMed
Kratochwill, TR, Hitchcock, J, Horner, RH, Levin, JR, Odom, SL, Rindskopf, DM, Shadish, WR (2010). Single-case designs. Technical documentation. What Works Clearinghouse: http://ies.ed.gov/ncee/wwc/pdf/wwc_scd.pdf.Google Scholar
Kratochwill, TR, Hitchcock, J, Horner, RH, Levin, JR, Odom, SL, Rindskopf, DM, Shadish, WR (2013). Single-case intervention research design standards. Remedial and Special Education 34, 2638.Google Scholar
Kubina, RM, Ward, MC, Mozzoni, MP (2000). Helping one person at a time: precision teaching and traumatic brain injury rehabilitation. Behavioral Interventions 15, 189203.Google Scholar
Kurz, A, Thone-Otto, A, Cramer, B, Egert, S, Frolich, L, Gertz, HJ, Kehl, V, Wagenpfeil, S, Werheid, K (2012). CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial. Alzheimer Disease and Associated Disorders 26, 246253.CrossRefGoogle Scholar
Lane, JD, Gast, DL (2014). Visual analysis in single case experimental design studies: brief review and guidelines. Neuropsychological Rehabilitation 24, 445463.3.0.CO;2-X>CrossRefGoogle Scholar
Lawton, MP, Brody, EM (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9, 179186.CrossRefGoogle ScholarPubMed
Lindsley, O (1991). Precision teaching’s unique legacy from B. F. Skinner. Journal of Behavioral Education 1, 253266.CrossRefGoogle ScholarPubMed
Logsdon, RG, Gibbons, LE, McCurry, SM, Teri, L (1999). Quality of life in Alzheimer’s disease: patient and caregiver reports. Journal of Mental Health and Aging 5, 2132.CrossRefGoogle ScholarPubMed
Manolov, R, Losada, JL, Chacón-Moscoso, S, Sanduvete-Chaves, S (2016). Analyzing two-phase single-case data with non-overlap and mean difference indices: illustration, software tools, and alternatives. Frontiers in Psychology 7, 32.CrossRefGoogle Scholar
Martin, M, Clare, L, Altgassen, AM, Cameron, MH, Zehnder, F (2011). Cognition-based interventions for healthy older people and people with mild cognitive impairment. Cochrane Database of Systematic Reviews, CD006220.Google Scholar
Nasreddine, ZS, Phillips, NA, Bedirian, V, Charbonneau, S, Whitehead, V, Collin, I, Cummings, JL, Chertkow, H (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society 53, 695699.CrossRefGoogle ScholarPubMed
Oren, S, Willerton, C, Small, J (2014). Effects of spaced retrieval training on semantic memory in Alzheimer’s disease: a systematic review. Journal of Speech Language and Hearing Research 57, 247270.CrossRefGoogle Scholar
O’Sullivan, M, Coen, R, O’Hora, D, Shiel, A (2015). Cognitive rehabilitation for mild cognitive impairment: developing and piloting an intervention. Aging Neuropsychology and Cognition: A Journal on Normal and Dysfunctional Development 5, 280300.Google Scholar
Randolph, C, Tierney, MC, Mohr, E, Chase, TN (1998). The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. Journal of Clinical and Experimental Neuropsychology 20, 310319.CrossRefGoogle ScholarPubMed
Ready, RE, Ott, BR (2003). Quality of life measures for dementia. Health and Quality of Life Outcomes 1, 11.CrossRefGoogle Scholar
Sitzer, DI, Twamley, EW, Jeste, DV (2006). Cognitive training in Alzheimer’s disease: a meta-analysis of the literature. Acta Psychiatrica Scandinavica 114, 7590.CrossRefGoogle ScholarPubMed
Shadish, WR, Rindskopf, DM (2007). Methods for evidence-based practice: quantitative synthesis of single-subject designs. New Directions for Evaluation 113, 95109, https://doi.org/10.1002/ev.217.CrossRefGoogle ScholarPubMed
Shadish, WR, Sullivan, KJ (2011). Characteristics of single-case designs used to assess intervention effects in 2008. Behavior Research Methods 43, 971980.CrossRefGoogle Scholar
Shadish, WR (2014). Statistical analysis of single-case designs: the shape of things to come. Current Direction in Psychological Science 23, 139146.CrossRefGoogle Scholar
Skinner, BF (1953). Science and Human Behavior. Macmillan: Oxford, England.CrossRefGoogle ScholarPubMed
Suhr, J (1999). Progressive muscle relaxation in the management of behavioural disturbance in Alzheimer’s disease. Neuropsychological Rehabilitation 9, 3144.CrossRefGoogle Scholar
Tate, RL, Perdices, M, McDonald, S, Togher, L, Rosenkoetter, U (2014). The design, conduct and report of single-case research: resources to improve the quality of the neurorehabilitation literature. Neuropsychological Rehabilitation 24, 315331.Google Scholar
Tate, R, McDonald, S, Perdices, M, Togher, L, Schultz, R, Savage, S (2008). Rating the methodological quality of single-subject designs and n-of-1 trials: introducing the Single-Case Experimental Design (SCED) Scale. Neuropsychological Rehabilitation 18, 385401.CrossRefGoogle Scholar
Tate, RL, Perdices, M, Rosenkoetter, U, Wakim, D, Godbee, K, Togher, L, McDonald, S (2013). Revision of a method quality rating scale for single-case experimental designs and n-of-1 trials: the 15-item Risk of Bias in N-of-1 trials (RoBiNT) Scale. Neuropsychological Rehabilitation 23, 619638, doi: http://dx.doi.org/%2010.1080/09602011.2013.824383.CrossRefGoogle ScholarPubMed
Terrace, HS (1963). Discrimination learning with and without “errors”. Journal of the Experimental Analysis of Behavior 6, 127.CrossRefGoogle ScholarPubMed
Trahan, MA, Kahng, S, Fisher, A, Hausman, NL (2011). Behavior analytic research on dementia in older adults. Journal of Applied Behavior Analysis 44, 687691.CrossRefGoogle ScholarPubMed
Trahan, MA, Kuo, J, Carlson, M, Gitlin, LN (2014). A systematic review of strategies to foster activity engagement in persons with dementia. Health Education and Behaviour 41 (Suppl.): 70S83S.CrossRefGoogle ScholarPubMed
Zarit, S, Orr, NK, Zarit, JM (1985). The Hidden Victims of Alzheimer’s Disease: Families Under Stress. New York University Press: New York.CrossRefGoogle ScholarPubMed
Zigmond, AS, Snaith, RP (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67, 361370.CrossRefGoogle ScholarPubMed