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A multiparametric approach to discriminate the impacts of different degrees of invasiveness of surgical procedures in sheep

Published online by Cambridge University Press:  04 May 2017

M. Faure ,
V. Paulmier ,
A. Boissy ,
A. de La Foye ,
A. de Boyer Des Roches  and
D. Durand
M. Faure
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France Université de Lyon – VetAgro Sup, UMR 1213 Herbivores, F-69280 Marcy l’Etoile, France
V. Paulmier
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France
A. Boissy
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France Université de Lyon – VetAgro Sup, UMR 1213 Herbivores, F-69280 Marcy l’Etoile, France
A. de La Foye
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France Université de Lyon – VetAgro Sup, UMR 1213 Herbivores, F-69280 Marcy l’Etoile, France
A. de Boyer Des Roches
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France Université de Lyon – VetAgro Sup, UMR 1213 Herbivores, F-69280 Marcy l’Etoile, France
D. Durand*
Affiliation:
Institut National de la Recherche Agronomique, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France Université de Lyon – VetAgro Sup, UMR 1213 Herbivores, F-69280 Marcy l’Etoile, France
*
†E-mail: denys.durand@inra.fr
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Abstract

Traumatic situations in animals induce responses including pain, expressed through behavioural and physiological pathways such as inflammation, oxidative stress, hypothalamic–pituitary–adrenal (HPA) axis and autonomic nervous system. As some of these systems can also be activated during excitement and situations with a positive valence, their use as a means to assess pain response is difficult. We explored (i) how these five aforementioned pathways change in sheep exposed to various degrees of invasiveness of surgical procedures despite a therapeutic regimen and (ii) whether a multiparametric analysis that combines information from these five pathways enhances the discrimination between these situations, and estimates the relative importance of these pathways in the response. We used 24 adult sheep split into four treatments: Control (C; no fasting, no anaesthesia, no surgery), Sham (S; fasting, anaesthesia, no surgery), Rumen Canulation (R; fasting, anaesthesia, rumen cannulation) and Rumen–Duodenal–Ileum cannulation (RDI; fasting, anaesthesia, cannulation of the rumen, duodenum and ileum). Sheep’ responses were measured for 5 days after surgery. When considering each behavioural or physiological pathway independently, discrimination between treatments was acceptable, its sensitivity (Se) ranging from 0% to 100%, and its specificity (Sp) ranging from 62% to 100%. The multiparametric analysis gathering information from the five pathways enhanced the effectiveness of discrimination between treatments (Se, 50% to 100%; Sp, 82% to 100%), and gave additional information on the relative contribution of each pathway to the global sheep response. Sheep global response was higher when exposed to a surgery, and increased with the surgery invasiveness. This response relied mostly on inflammation (absolute correlation for haptoglobin, 0.89), HPA (cortisol, 0.85) and behaviour (antalgic postures, 0.85). The multiparametric approach seems to be a promising tool to discriminate between different degrees of invasiveness of surgical procedures.

Keywords

painstresssurgeryruminantmultiparametric approach
Type
Research Article
Information
animal , Volume 11 , Issue 12 , December 2017 , pp. 2275 - 2284
Copyright
© The Animal Consortium 2017 

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Footnotes

a

These two authors contributed equally to this work.

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