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Direct FIB fabrication and integration of “single nanopore devices” for the manipulation of macromolecules

Published online by Cambridge University Press:  31 January 2011

Birgitta Schiedt
Affiliation:
birgitta.schiedt@lpn.cnrs.fr, LPN-CNRS, Marcoussis, France
Loic Auvray
Affiliation:
loic.auvray@univ-evry.fr, Université d'Evry Val d'Essonne, MPI, Evry, France
Laurent Bacri
Affiliation:
laurent.bacri@univ-evry.fr, Université d'Evry Val d'Essonne, MPI, Evry, France
Anne-Laure Biance
Affiliation:
Anne-Laure.Biance@lpmcn.univ-lyon1.fr, Univ. Claude Bernard Lyon 1, LPMCN, Villeurbanne, France
Ali Madouri
Affiliation:
ali.madouri@lpn.cnrs.fr, LPN-CNRS, Marcoussis, France
Eric Bourhis
Affiliation:
eric.bourhis@lpn.cnrs.fr, LPN-CNRS, Marcoussis, France
Gilles Patriarche
Affiliation:
gilles.patriarche@lpn.cnrs.fr, LPN-CNRS, Marcoussis, France
Juan Pelta
Affiliation:
Jpelta@univ-evry.fr, Université de Cergy-Pontoise, Cergy-Pontoise, France
Ralf Jede
Affiliation:
jede@raith.de, RAITH GmbH, Dortmund, Germany
Jacques Gierak
Affiliation:
jacques.gierak@lpn.cnrs.fr, LPN-CNRS, Marcoussis, France
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Abstract

Here we propose to detail an innovative FIB instrumental approach and processing methodologies we have developed for sub-10 nm nanopore fabrication. The main advantage of our method is first to allow direct fabrication of nanopores in relatively large quantities with an excellent reproducibility. Second our approach offers the possibility to further process or functionalize the vicinity of each pore on the same scale keeping the required deep sub-10 nm scale positioning and patterning accuracy. We will summarise the optimisation efforts we have conducted aiming at fabricating thin (10-100 nm thick) and high quality dielectric films to be used as a template for the nanopore fabrication, and at performing efficient and controlled FIB nanoengraving of such a delicate media. Finally, we will describe the method we have developed for integrating these “single nanopore devices” in electrophoresis experiments and our preliminary measurements.

Type
Research Article
Copyright
Copyright © Materials Research Society 2009

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References

1 Biance, A.L. Gierak, J. Bourhis, E. Madouri, A. Lafosse, X. Patriarche, G. Oukhaled, G. Ulysse, C. Galas, J.C. Chen, Y. Auvray, L. Microelectronic Engineering 83, 1474 (2006)10.1016/j.mee.2006.01.133Google Scholar
2 Healy, K. Schiedt, B., Morrison, A.P. Nanomedicine 2, 875 (2007)10.2217/17435889.2.6.875Google Scholar
3 Branton, D. et al. , Nature Biotechnology 26, 1146 (2008)10.1038/nbt.1495Google Scholar
4. Nano-FIB project. EC GROWTH – G5RD-CT2000-00344 See also ftp://ftp.cordis.europa.eu/pub/nmp/docs/nanofib_info2.pdfGoogle Scholar
5 Gierak, J. Septier, A. and Vieu, C. Nucl. Instrum. Meth. A 427, 91 (1999)Google Scholar
6 Gierak, J. Madouri, A. Biance, A.L. Bourhis, E. Patriarche, G. Ulysse, C. Lucot, D. Lafosse, X. Auvray, L. Bruchhaus, L. and Jede, R. Microelectronic Engineering 84, 779 (2007)10.1016/j.mee.2007.01.059Google Scholar
7 Gierak, J. Semicond. Sci. Technol. 24, 23 (2009)10.1088/0268-1242/24/4/043001Google Scholar
8 Gierak, J. et al. , Mater. Res. Soc. Symp. Proc. Vol. 1089 (2008)10.1557/PROC-1089-Y03-01Google Scholar
9 Patterson, N.. Adams, D.P. Hodges, V.C. Vasile, M.J. Michael, J.R. and Kotula, P.G. Nanotechnology 19, 235304 (2008)10.1088/0957-4484/19/23/235304Google Scholar
10 Pelta, J. Berry, H. Fadda, G. C. Pauthe, E. and Lairez, D. Biochemistry 39, 5146, (2000)10.1021/bi992770xGoogle Scholar