Hostname: page-component-76fb5796d-5g6vh Total loading time: 0 Render date: 2024-04-25T15:14:15.681Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft

Published online by Cambridge University Press:  11 February 2011

Stephen A. Doherty ,
David D. Hile ,
Donald L. Wise ,
Jackie Y. Ying ,
Stephen T. Sonis  and
Debra J. Trantolo
Stephen A. Doherty
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
David D. Hile
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
Donald L. Wise
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
Jackie Y. Ying
Affiliation:
Massachusetts Institute of Technology, Department of Chemical Engineering, Cambridge, MA
Stephen T. Sonis
Affiliation:
Harvard School of Dental Medicine, Dept. of Oral Medicine and Diagnostics Sciences, Boston, MA
Debra J. Trantolo
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
Get access

Abstract

A nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(propylene glycol-co-fumaric acid) (PPF), was used to prepare the bone graft substitute. The nanoparticulate-hydroxyapatite filler was examined in terms of biocompatibility, bony ingrowth and mechanical stability in a rat calvarial defect model. The nano-hydroxyapatite fillerwas compared against a commercially available micrometer-sized hydroxyapatite(HA) filler. Histological analysis indicated that remodeling of the newly formed bone was more advanced in the defect filled with the nano-hydroxyapatite augmented PPF. Mechanical evaluation showed a more rapid increase in stiffness of the nano-hydroxyapatite PPF. Implants of the nano-HA augmented PPF showed more advanced bone formation and recovery of mechanical properties, suggesting an improved biological response to the nano-sized particles.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 735: Symposium C – Bioinspired Nanoscale Hybrid Systems , 2002 , C6.4
Copyright
Copyright © Materials Research Society 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Doherty, SA; Hile, DD; Wise, DL; Lewandrowski, K.U.; Trantolo, DJ In Press. Synthesis and evaluation of a poly(propylene glycol-co-fumaric acid) bone graft extender in Biomaterials Handbook-Advanced Applications of Basic Sciences and Bioengineering, ed, Wise, DL, Hasirci, V, Yaszemski, MJ, Altobelli, DE, Lewandrowski, KU, and Trantolo, DJ. New York: Marcel Decker,Google Scholar
2. Hile, DD; Kirker-Head, C; Doherty, SA; Lewandrowski, K.U.; Kowaleski, MP; McCool, J; Wise, DL and Trantolo, D.J. 2002. Mechanical evaluation of a porous bone graft substitute based on poly(propylene glycol-co-fumaric acid). J Biomed Mater Res. In press.Google Scholar
3. Lewandrowski, K.U., Bondre, SP, Wise, DL, Ying, JY, and Trantolo, DJ Bioactivity of nano-hydroxyapatite in a scaffold for periodontal repair in Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications, Marcel Decker, NY 2002.Google Scholar
4. Du, C.; Cui, FZ; Zhu, XD; de Groot, K 1998. Three-dimensional nano-HA/collagen matrix loading with osteogenic cells in organ culture. J. Biomed. Mater Res. 44(4): 407–415.Google Scholar
5. Lewandrowski, K.U., Gresser, J.D., Wise, D.L., and Trantolo, D.J.. 2000. Bioresorbable bone graft substitutes of different osteoconductivities: a histological evaluation of osteointergration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats. Biomaterials. 21: 757–764.Google Scholar
6. Yaszemski, M.J., Payne, R.G., Hayes, W.C., Langer, R., and Mikos, A.G.. 1996. In vitro degradation of a poly(propylene fumarate)-based composite material. Biomaterials 17(22): 2127–30.Google Scholar
7. Gresser, J.D., Hsu, S.H., Nagaoka, H., Lyons, C.M., Nieratko, D.P., Wise, D.L., Barabino, G.A., and Trantolo, D.J.. 1995. Analysis of a vinyl pyrrolidone/poly(propylene fumarate) resorbable bone cement, J. Biomed. Mat. Res. 29: 1241–47.Google Scholar
8. Pettis, GY, Kaban, LB, Glowacki, J. 1990. Tissue response to composite ceramic hydroxyapatite/demineralized bone implants. J Oral Maxillofac Surg 48(10): 1068–74.Google Scholar