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Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteers

Published online by Cambridge University Press:  07 May 2002

S. SOBCZAK
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands
W. J. RIEDEL
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands
I. BOOIJ
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands
M. AAN HET ROT
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands
N. E. P. DEUTZ
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands
A. HONIG
Affiliation:
From the Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology and Department of Surgery, Universiteit Maastricht, The Netherlands

Abstract

Background. Serotonergic circuits have been proposed to mediate cognitive processes, particularly learning and memory. Cognitive impairment is often seen in bipolar disorders in relation to a possible lowered serotonergic turnover.

Methods. We investigated the effects of acute tryptophan depletion (ATD) on cognitive performance in healthy first-degree relatives of bipolar patients (FH) (N = 30) and matched controls (N = 15) in a placebo-controlled, double-blind cross-over design. Performance on planning, memory and attention tasks were assessed at baseline and 5 h after ATD.

Results. Following ATD, speed of information processing on the planning task was impaired in the FH group but not in the control group. FH subjects with a bipolar disorder type I relative (FH I) showed impairments in planning and memory, independent of ATD. In all subjects, ATD impaired long-term memory performance and speed of information processing. ATD did not affect short-term memory and focused and divided attention.

Conclusions. The results suggest serotonergic vulnerability affecting frontal lobe areas in FH subjects, indicated by impaired planning. Biological vulnerability in FH I subjects is reflected in impaired planning and memory performance. In conclusion, the cognitive dysfunctions in FH subjects indicate an endophenotype constituting a possible biological marker in bipolar psychopathology. Serotonin appears to be involved in speed of information processing, verbal and visual memory and learning processes.

Type
Original Article
Copyright
© 2002 Cambridge University Press

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