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Association between PrP genotypes and performance traits in a Welsh Mountain flock

Published online by Cambridge University Press:  01 October 2008

T. C. Pritchard ,
C. M. Cahalan  and
I. Ap Dewi
T. C. Pritchard*
Affiliation:
School of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UK
C. M. Cahalan
Affiliation:
School of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UK
I. Ap Dewi
Affiliation:
School of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UK
*
E-mail: pritchard.tc@gmail.com
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Abstract

The UK national scrapie plan (NSP) for sheep is based on selection for the resistant ARR/ARR genotype and elimination of susceptible types of the ovine prion protein (PrP) gene. The aim of this study was to estimate the possible association of the PrP genotype and performance traits by using data from the CAMDA Welsh Mountain flock. Four alleles (ARH, ARQ, ARR and VRQ) and 10 genotypes covering all five NSP risk groups were present in the CAMDA flock. Overall, the most common allele was ARR (35.2%), and VRQ was the least common (5.4%). The commonest genotypes were ARR/ARQ (23.7%) and ARR/AHQ (23.1%). The most resistant genotype, ARR/ARR, and the most susceptible genotype, VRQ/VRQ, were found in 10.2% and 0.3%, respectively, of the population tested. The associations of PrP genotypes with weight and ultrasonically scanned traits were investigated in three analyses, the first using genotypes, the second using risk categories and the third using number of alleles. These associations were evaluated by univariate analysis of each trait using an animal model with maternal effects where appropriate, and PrP was included as a fixed effect. Selection for scrapie resistance will not adversely affect progress in the traits considered and is consistent with improvements in muscle depth.

Keywords

performance traitsPrP genotypescrapieWelsh Mountain sheep
Type
Full Paper
Information
animal , Volume 2 , Issue 10 , October 2008 , pp. 1421 - 1426
Copyright
Copyright © The Animal Consortium 2008

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References

Alexander, BM, Stobart, RH, Russell, WC, O’Rourke, KI, Lewis, GS, Logan, JR, Duncan, JR, Moss, GE 2005. The incidence of genotypes at codon 171 of the prion protein gene (prnp) in five breeds of sheep and production traits of ewes associated with those genotypes. Journal of Animal Science 83, 455–459.CrossRefGoogle ScholarPubMed
Barillet F, Andréoletti O, Palhière I, Augerre X, Arranz JM, Minery S, Soulas C, Belloc JP, Briois M, Frégeat G, Teinturier P, Amigues Y, Astruc JM, My B and Schelcher F 2002. Breeding for scrapie resistance using PrP genotyping in the French dairy sheep breeds. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier, pp. 19–23.Google Scholar
Baylis, M, Chihota, C, Stevenson, E, Goldmann, W, Smith, A, Sivarn, K, Tongue, S, Gravenor, MB 2004. Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology 85, 2735–2740.CrossRefGoogle ScholarPubMed
Bossers, A, De Vries, R, Smits, MA 2000. Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP. Journal of Virology 74, 1407–1414.Google Scholar
Brandsma, JH, Janss, LLG, Visscher, AH 2004. Association between PrP genotypes and litter size and 135 days weight in Texel sheep. Livestock Production Science 85, 59–64.Google Scholar
Casellas, J, Caja, G, Bach, R, Francino, O, Piedrafita, J 2007. Association analyses between the prion protein locus and reproductive and lamb weight traits in Ripollesa sheep. Journal of Animal Science 85, 592–597.CrossRefGoogle ScholarPubMed
Dawson, M, Hoinville, LJ, Hosie, BD, Hunter, N 1998. Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Veterinary Record 142, 623–625.Google Scholar
Dekkers, JCM 2004. Commercial application of marker- and gene-assisted selection in livestock: strategies and lessons. Journal of Animal Science 82 (Suppl. E), E313–E328.Google ScholarPubMed
De Vries, F, Borchers, N, Hamann, H, Drogemuller, C, Reinecke, S, Lupping, W, Distl, O 2004a. Associations between the prion protein genotype and performance traits of meat breeds of sheep. Veterinary Record 155, 140–143.CrossRefGoogle ScholarPubMed
De Vries, F, Hamann, H, Drogemuller, C, Garter, M, Distl, O 2004b. Analysis of associations between the prion protein genotype and reproductive traits in meat sheep breeds. Animal Science 79, 397–404.CrossRefGoogle Scholar
De Vries, F, Hamann, H, Drogemuller, C, Ganter, M, Distl, O 2005. Analysis of associations between the prion protein genotypes and production traits in East Friesian milk sheep. Journal of Dairy Science 88, 392–398.Google Scholar
Dodds, KG, McEvan, JC, Davis, GH 2007. Integration of molecular and quantitative information in sheep and goat industry breeding programmes. Small Ruminant Research 70, 32–41.Google Scholar
Eglin, RD, Warner, R, Gubbins, S, Sivam, SK, Dawson, M 2005. Frequencies of PrP genotypes in 38 breeds of sheep sampled in the National Scrapie Plan for Great Britain. Veterinary Record 156, 433–437.CrossRefGoogle ScholarPubMed
Elsen, JM, Amigues, Y, Schelcher, F, Ducrocq, V, Andréoletti, O, Eychenne, F, Tien Khang, JV, Poivey, JP, Lantier, F, Laplanche, JL 1999. Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Archives of Virology 144, 431–445.CrossRefGoogle Scholar
Gilmour AR, Gogel BJ, Cullis BR, Welham SJ and Thompson R 2002. ASReml User Guide Release 1.0. VSN International Ltd, Hemel Hempstead, UK.Google Scholar
Gmur, B, Gaillard, C, Dolf, G 2004. Characterization of the prion protein gene (PRNP) region in Swiss sheep breeds. Journal of Animal Breeding and Genetics 121, 216–220.Google Scholar
Houston, F, Goldman, W, Chong, A, Jeffrey, M, Gonzalez, L, Foster, J, Parnham, D, Hunter, N 2003. Prion diseases: BSE in sheep bred for resistance to infection. Nature 423, 498.CrossRefGoogle ScholarPubMed
Isler, BJ, Freking, BA, Thallman, RM, Heaton, MP, Leymaster, KA 2006. Evaluation of associations between prion haplotypes and growth, carcass, and meat quality traits in a Dorset × Romanov sheep population. Journal of Animal Science 84, 783–788.Google Scholar
Kao, RR, Houston, F, Baylis, M, Chihota, CM, Goldmann, W, Gravenor, MB, Hunter, N, Mclean, AR 2003. Epidemiological implications of the susceptibility to BSE of putatively resistant sheep. Journal of General Virology 84, 3503–3512.CrossRefGoogle ScholarPubMed
Lonyong, JD 2003. Genetic resistance to scrapie in a flock of Welsh Mountain sheep. MSc, University of Wales, Bangor, UK.Google Scholar
Lonyong JD, Pritchard TC and Ap Dewi I 2004. Genetic resistance to scrapie in a flock of Welsh Mountain sheep. Proceedings of the British Society of Animal Science – Annual Meeting 2004, York, UK, p. 226.Google Scholar
Man WYN, Brotherstone S, Merrell BG, Murray WA and Villanueva B 2006. Analysis of association between the PrP gene and the live weight and slaughter traits in an experimental flock of Swaledale sheep in the UK. In Proceedings of the British Society of Animal Science – Annual Meeting 2006, York, UK, p. 3.CrossRefGoogle Scholar
Ponz, R, Tejedor, MT, Montengudo, LV, Arruga, MV 2006. Scrapie resistant alleles are not associated with lower prolificity in Rasa Aragonesa sheep. Research in Veterinary Science 81, 37–39.Google Scholar
Roden JA, Haresign W and Anderson JML 2001. Analysis of PrP genotype in relation to performance traits in Suffolk sheep. Proceedings of the British Society of Animal Science – Annual Meeting 2001, York, UK, p. 45.Google Scholar
Roden, JA, Nieuwhof, GJ, Bishop, SC, Jones, DA, Haresign, W, Gubbins, S 2006. Breeding programmes for TSE resistance in British sheep: I. Assessing the impact on prion protein (PrP) genotype frequencies. Preventive Veterinary Medicine 73, 1–16.CrossRefGoogle ScholarPubMed
Sawalha RM, Brotherstone S, Man WYN, Conington J, Bunger L and Villanueva B 2006. Association between polymorhisms of the ovine prion protein gene and lamb performance traits of Scottish Blackface sheep. In Proceedings of the British Society of Animal Science – Annual Meeting 2006, York, UK, p. 2.Google Scholar
Signet 2007. Recording protocols: practical requirements for sheep scanning. Retrieved August 8, 2007 from http://www.signetfbc.co.ukGoogle Scholar
Slate, J 2005. Molecular evolution of the sheep prion protein gene. Proceedings of the Royal Society of London. Series B. Biological Sciences 272, 2371–2377.Google ScholarPubMed
Tranulis, MA 2002. Influence of the prion protein gene Prnp on scrapie susceptibility in sheep. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 110, 33–43.CrossRefGoogle ScholarPubMed
Vitezica, ZG, Moreno, CR, Bouix, J, Barillet, F, Perret, G, Elsen, JM 2005. A study on associations between PrP genotypes and meat traits in French sheep breeds. Animal Science 81, 325–330.CrossRefGoogle Scholar
Vitezica, ZG, Moreno, CR, Bodin, L, Francois, D, Barillet, F, Brunel, JC, Elsen, JM 2006. No association between PrP genotypes and reproductive traits in INRA 401 sheep. Journal of Animal Science 84, 1317–1322.Google Scholar
Warner, R 2003. The National Scrapie Plan: Richard Warner outlines progress and developments. Sheep Farmer: The Journal of the National Sheep Association 22, 24.Google Scholar
Woolhouse, MEJ, Coen, P, Matthews, L, Foster, JD, Elsen, J, Lewis, RM, Haydon, DT, Hunter, N 2001. A centuries-long epidemic of scrapie in British sheep. Trends in Microbiology 9, 67–70.CrossRefGoogle ScholarPubMed