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Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties

Published online by Cambridge University Press:  05 June 2014

Stephen M. Stahl
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Abstract

ISSUE:A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.

Type
Brainstorms
Information
CNS Spectrums , Volume 19 , Issue 3 , June 2014 , pp. 207 - 212
Copyright
Copyright © Cambridge University Press 2014 

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