Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-24T23:58:30.209Z Has data issue: false hasContentIssue false
  • English
  • Français

Controlled Growth Factor Delivery By Mechanical Stimulation

Published online by Cambridge University Press:  17 March 2011

Kuen Yong Lee ,
Martin C. Peters ,
Kenneth W. Anderson  and
David J. Mooney
Kuen Yong Lee
Affiliation:
Dept. of Biologic & Materials Sciences, Chemical Engineering, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, U.S.A.
Martin C. Peters
Affiliation:
Dept. of Biologic & Materials Sciences, Chemical Engineering, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, U.S.A.
Kenneth W. Anderson
Affiliation:
Dept. of Biologic & Materials Sciences, Chemical Engineering, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, U.S.A.
David J. Mooney
Affiliation:
Dept. of Biologic & Materials Sciences, Chemical Engineering, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, U.S.A.
Get access

Abstract

Growth factor delivery using polymer matrices is one exciting approach to replace or regenerate tissues. Most growth factor delivery systems, however, have been designed to operate under static conditions, regardless of dynamic environments in the body. Considering the dynamic environment of our body (e.g., bone, muscle, and blood vessel), mechanical stimulation is an important signal that could be readily exploited. We hypothesize that polymer matrices, which release growth factors in response to mechanical stimulation, could provide a novel approach to engineer tissues in mechanically stressed environments. We report here a model system, comprised of alginate hydrogel and vascular endothelial growth factor (VEGF), which upregulates the release of the growth factor in response to mechanical stimulation and subsequently promotes granulation tissue formation in animals. This approach may find a number of potential applications in tissue engineering, as well as in drug delivery.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , GG2.2.1
Copyright
Copyright © Materials Research Society 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Winn, S.R., Uludag, H., and Hollinger, J.O., Adv. Drug Deliv. Rev. 31, 303 (1998).Google Scholar
2. Epstein, S.E., Fuchs, S., Zhou, Y.F., Baffour, R., and Kornowski, R., Cardiovascular Res. 49, 532 (2001).Google Scholar
3. Lee, K.Y. and Mooney, D.J., Chem. Rev. 101, 1869 (2001).Google Scholar
4. Langer, R., Nature 392 (suppl.), 5 (1998).Google Scholar
5. Lee, K.Y., Peters, M.C., Anderson, K.W., and Mooney, D.J., Nature 408, 998 (2000).Google Scholar
6. Lee, K.Y., Peters, M.C., and Mooney, D.J., Adv. Mater. 13, 837 (2001).Google Scholar
7. Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z., FASEB J. 13, 9 (1999).Google Scholar
8. Colton, C.K., Cell Transplantation 4, 415 (1995).Google Scholar