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Drug Deliverable, Self-assembled Rosette Nanotubes (RNTs) for Orthopedic Applications

Published online by Cambridge University Press:  31 January 2011

Yupeng Chen ,
Shang Song ,
Hicham Fenniri  and
Thomas J Webster
Yupeng Chen
Affiliation:
Yupeng_chen@brown.edu, Brown University, 324 Brook Street, Providence, Rhode Island, 02912, United States
Shang Song
Affiliation:
Shang_song@brown.edu, Brown University, Providence, Rhode Island, United States
Hicham Fenniri
Affiliation:
hicham.fenniri@ualberta.ca, University of Alberta, Edmonton, Canada
Thomas J Webster
Affiliation:
thomas.webster@scholarone.com, United States
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Abstract

Rosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV light or crosslinking agents). The nano-features of RNTs create a favorable, biologically-inspired, cellular environment. In this study, methods to incorporate dexamethasone (DEX, a bone growth promoting drug) into RNTs were investigated. The drug-loaded RNTs were characterized using Nuclear Magnetic Resonance (NMR), Diffusion Ordered Spectroscopy (DOSY) and Ultraviolet-visible Spectroscopy (UV-vis). Results showed that small molecular drugs with hydrophobic aromatic rings were incorporated into RNTs. Subsequent drug release experiments demonstrated that DEX was released from the RNTs and had a positive impact on osteoblast functions. Importantly, compared to other drug carriers, RNTs increased the total drug loading and was the highest when DEX was incorporated during the RNT self-assembly process. Thus, this study offered a novel drug delivery device that itself is bioactive and can be used to deliver a variety of drugs for various orthopedic applications.

Keywords

nanostructureboneadsorption
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1209: Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology , 2009 , 1209-YY07-17
Copyright
Copyright © Materials Research Society 2010

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