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Rapid development of pulmonary hypertension during treatment of paediatric cancer

Published online by Cambridge University Press:  25 January 2019

Manish Aggarwal ,
Laura Schuettpelz ,
Julie Kolodziej  and
R. Mark Grady
Manish Aggarwal*
Affiliation:
Department of Pediatrics, Washington University School of Medicine, Children’s Place, St Louis, MO, USA
Laura Schuettpelz
Affiliation:
Department of Pediatrics, Washington University School of Medicine, Children’s Place, St Louis, MO, USA
Julie Kolodziej
Affiliation:
Department of Pediatrics, Washington University School of Medicine, Children’s Place, St Louis, MO, USA
R. Mark Grady
Affiliation:
Department of Pediatrics, Washington University School of Medicine, Children’s Place, St Louis, MO, USA
*
Author for correspondence: M. Aggarwal, Texas Children’s Hospital/Baylor College of Medicine, Pediatric Cardiology, 6621 Fannin Street, MC 19345-C, Houston, TX 77030, USA. Tel: 832-826-5715; Fax: 832-825-1906; E-mail: manish.aggarwal@bcm.edu
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Abstract

Paediatric pulmonary hypertension has been described as a secondary complication of multiple diseases and their treatment. Limited information exists about the relationship between pulmonary hypertension and cancer in children. A review of charts was performed in all patients treated for cancer and developed pulmonary hypertension. A total of four patients developed pulmonary hypertension during treatment of cancer. All patients had solid tumors, had echocardiographic evidence of elevated right ventricular pressures, and required intensive care stays. Treatment courses included inhaled and oral pulmonary vasodilators along with systemic steroids. Each had normalisation of echocardiograms and resolution of pulmonary symptoms. Prompt diagnosis of pulmonary hypertension and treatment with pulmonary vasodilators and steroids are considered important measures followed by chemotherapy and radiation regimens.

Keywords

Secondary pulmonary hypertensionpaediatric pulmonary hypertensionsolid tumour treatmentintensive care
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 3 , March 2019 , pp. 286 - 289
Copyright
© Cambridge University Press 2019 

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Footnotes

Cite this article: Aggarwal M, Schuettpelz L, Kolodziej J, Grady RM (2019) Rapid development of pulmonary hypertension during treatment of paediatric cancer. Cardiology in the Young29: 286–289. doi: 10.1017/S1047951118002196

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