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Comparison of Semantic and Episodic Memory BOLD fMRI Activation in Predicting Cognitive Decline in Older Adults

Published online by Cambridge University Press:  30 November 2012

Nathan Hantke ,
Kristy A. Nielson ,
John L. Woodard ,
Leslie M. Guidotti Breting ,
Alissa Butts ,
Michael Seidenberg ,
J. Carson Smith ,
Sally Durgerian ,
Melissa Lancaster  and
Monica Matthews
...Show all authors
Nathan Hantke
Affiliation:
Department of Psychology, Marquette University, Milwaukee, Wisconsin
Kristy A. Nielson
Affiliation:
Department of Psychology, Marquette University, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
John L. Woodard
Affiliation:
Department of Psychology, Wayne State University, Detroit, Michigan
Leslie M. Guidotti Breting
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
Alissa Butts
Affiliation:
Department of Psychology, Marquette University, Milwaukee, Wisconsin
Michael Seidenberg
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
J. Carson Smith
Affiliation:
Department of Kinesiology, University of Maryland, College Park, Maryland
Sally Durgerian
Affiliation:
Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
Melissa Lancaster
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
Monica Matthews
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
Michael A. Sugarman
Affiliation:
Department of Psychology, Wayne State University, Detroit, Michigan
Stephen M. Rao*
Affiliation:
Neurological Institute, Cleveland Clinic, Cleveland, Ohio
*
Correspondence and reprint requests to: Stephen M. Rao, Schey Center for Cognitive Neuroimaging, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue/U10, Cleveland, OH 44195. E-mail: raos2@ccf.org
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Abstract

Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively “Stable” or “Declining” based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive outcome using a logistic regression analysis. Twenty-seven (34.6%) participants were classified as Declining and 51 (65.4%) as Stable. APOE ε4 status alone significantly predicted cognitive decline (R2 = .106; C index = .642). Addition of SM activation significantly improved prediction accuracy (R2 = .285; C index = .787), whereas the addition of EM did not (R2 = .212; C index = .711). In combination with APOE status, SM task activation predicts future cognitive decline better than EM activation. These results have implications for use of fMRI in prevention clinical trials involving the identification of persons at-risk for age-associated memory loss and Alzheimer's disease. (JINS, 2012, 18, 1–11)

Keywords

Magnetic resonance imagingAgingApolipoprotein-EMemory lossMild cognitive impairmentLongitudinal study
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 1 , January 2013 , pp. 11 - 21
Copyright
Copyright © The International Neuropsychological Society 2012

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