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Effect of high-dose oral cholecalciferol on cardiac mechanics in children with chronic kidney disease

Published online by Cambridge University Press:  03 August 2017

Murat Deveci ,
Mehmet Baha Aytaç ,
Gürkan Altun ,
Özlem Kayabey  and
Kadir Babaoğlu
Murat Deveci*
Affiliation:
Department of Pediatric Cardiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
Mehmet Baha Aytaç
Affiliation:
Department of Pediatric Nephrology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
Gürkan Altun
Affiliation:
Department of Pediatric Cardiology, Derince Training and Research Hospital, KocaeliTurkey
Özlem Kayabey
Affiliation:
Department of Pediatric Cardiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
Kadir Babaoğlu
Affiliation:
Department of Pediatric Cardiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
*
Correspondence to: M. Deveci, MD, Department of Pediatric Cardiology, Kocaeli University, Medical Faculty, Umuttepe Campus, 41020 Izmit, Kocaeli, Turkey. Tel: +90 533 542 16 67; Fax: +90 262 303 70 03; E-mail: m4deveci@yahoo.com
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Abstract

Cardiovascular factors are an important cause of mortality in chronic kidney disease, and vitamin-D deficiency is common in this patient population. Therefore, we aimed to investigate the effect of oral cholecalciferol on cardiac mechanics in children with chronic kidney disease. A total of 41 children with chronic kidney disease – the patient group – and 24 healthy subjects – the control group – free of any underlying cardiac or renal disease with low 25-hydroxyvitamin-D3 levels were evaluated by conventional tissue Doppler imaging and two-dimensional speckle-tracking echocardiography, both at baseline and following Stoss vitamin-D supplementation. Left ventricular strain and strain rate values were compared between the study groups. Initial longitudinal and radial strain as well as strain rate values of the left ventricle were significantly lower in patients. After vitamin-D supplementation, these improved significantly in patients, whereas no significant change was observed in the control group. Our study showed that, although conventional and tissue Doppler imaging methods could not determine any effect, two-dimensional speckle-tracking echocardiography revealed the favourable effects of high-dose cholecalciferol on cardiac mechanics, implying the importance of vitamin-D supplementation in children with chronic kidney disease.

Keywords

Childrenchronic kidney diseasetwo-dimensional speckle-tracking echocardiography25-hydroxyvitamin-D3
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 9 , November 2017 , pp. 1807 - 1814
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Copyright
© Cambridge University Press 2017 

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