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The Synthesis and Self-Assembly Studies of Two Bioactive BMP-7 Short Peptides Modified Rosette Nanotubes for Bone Tissue Engineering

Published online by Cambridge University Press:  14 March 2011

Alaaeddin Alsbaiee ,
Mounir El Bakkari  and
Hicham Fenniri
Alaaeddin Alsbaiee
Affiliation:
National Institute for Nanotechnology, Edmonton, T6G 2M9, Canada. Department of Chemistry, University of Alberta, Edmonton, T6G 2M9, Canada.
Mounir El Bakkari
Affiliation:
National Institute for Nanotechnology, Edmonton, T6G 2M9, Canada. Department of Chemistry, University of Alberta, Edmonton, T6G 2M9, Canada.
Hicham Fenniri*
Affiliation:
National Institute for Nanotechnology, Edmonton, T6G 2M9, Canada. Department of Chemistry, University of Alberta, Edmonton, T6G 2M9, Canada.
*
*E-mail: hicham.fenniri@nrc-cnrc.gc.ca
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Abstract

Bone fractures are one of the most common bone complications. In more severe cases, bone fixation is accomplished using titanium (Ti) implant materials. Unfortunately, the need for revision surgery often arises due to implant loosening and/or deterioration of the implant/bone interface. Rosette nanotubes (RNTs) are a class of self-assembled organic materials obtained through the self-assembly of a guanine-cytosine hybrid base (G∧C motif). These organic materials have been found to increase osteoblast (bone forming cells) adhesion and hydroxyapatite deposition (bone regeneration) on titanium implants as well as on engineered hydrogels. In order to increase the bioactivity of RNTs to enhance bone cell function on Ti implants, two RNT motifs functionalized with different bioactive deca-peptides (A, B) chosen from the knuckle region of bone morphogenic proteins-7 (BMP-7) were synthesized. Their self-assembly process was investigated in water using UV-Vis and SEM techniques.

Keywords

self-assemblybiomaterialnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1316: Symposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II , 2011 , mrsf10-1316-qq12-18
Copyright
Copyright © Materials Research Society 2011

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