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Biological Reaction to Electrically Polarized Hydroxyapatite

Published online by Cambridge University Press:  15 March 2011

Tomoko Sakai ,
Masato Ueshima ,
Sadao Morita ,
Satoshi Nakamura  and
Kimihiro Yamashita
Tomoko Sakai
Affiliation:
Institute of Biomaterials and Bioengineering, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, JAPAN Orthopedic Surgery, Tokyo Medical andDental University, 1-4-45 Yushima, Bunkyo-ku, Tokyo, JAPAN
Masato Ueshima
Affiliation:
Institute of Biomaterials and Bioengineering, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, JAPAN
Sadao Morita
Affiliation:
Orthopedic Surgery, Tokyo Medical andDental University, 1-4-45 Yushima, Bunkyo-ku, Tokyo, JAPAN
Satoshi Nakamura
Affiliation:
Institute of Biomaterials and Bioengineering, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, JAPAN
Kimihiro Yamashita
Affiliation:
Institute of Biomaterials and Bioengineering, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, JAPAN
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Abstract

We have studied the polarized hydroxyapatite (HAp) whose surface was negatively or positively charged. In this study, we assessed the interfaces in vitro and in vivo periodically. As in vitro experiment, samples were immersed in simulated body fluid for 7 days and the surface was examined by scanning electron microscope (SEM). As in vivo experiments, cortical bone defects were created on the femoral trochanters and the condyles of the six Japanese white rabbits and the samples were implanted. The rabbits were sacrificed at 1, 2 and 4 W after the operation to analyze the surfaces by the SEM and the optical microscopy. In this study, a new thick apatite layer was formed on the negatively charged surface (N-surface) after 1week immersion in SBF in vitro. Besides, significant new bone formation was found at 2 weeks after the operation on N-surface in vivo, which was earlier than positively charged or non-polarized HAp surface. From this study negatively charged HAp surface by polarization accelerated the HAp crystal growth or the new bone formation. Thus, this N-surface will be promising for earlier fixation of the prosthesis or better recovery of the bone defect.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 662: Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering , 2000 , LL3.4
Copyright
Copyright © Materials Research Society 2001

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