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In-Vivo Screening of Platelet-Biomaterial Interactions in a Baboon Model

Published online by Cambridge University Press:  26 February 2011

Anson A. Yeager ,
H. Hussein ,
N. Shoenfeld ,
K. Ramberg ,
R. Connolly  and
A. D. Callow
Anson A. Yeager
Affiliation:
Dept of Surgery, New England Medical Center, 750 Washington St., Boston, MA 02111
H. Hussein
Affiliation:
Dept of Surgery, New England Medical Center, 750 Washington St., Boston, MA 02111
N. Shoenfeld
Affiliation:
Dept of Surgery, New England Medical Center, 750 Washington St., Boston, MA 02111
K. Ramberg
Affiliation:
Dept of Radiology, New England Medical Center, 750 Washington St, Boston, MA 02111
R. Connolly
Affiliation:
Dept of Surgery, New England Medical Center, 750 Washington St., Boston, MA 02111
A. D. Callow
Affiliation:
Dept of Surgery, New England Medical Center, 750 Washington St., Boston, MA 02111
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Abstract

A percutaneous in-vig venous model was characterized by testing platelet deposition on standard vascular prosthetic materials in the baboon. The model detected significant difference in platelet deposition on ePTFE compared to Dacron. Low molecular weight dextran was administered following a baseline test period. A significant decrease in platelet depositionr occurred for both materials and coincided with a prolongation in bleeding time. No consistent decrease was found in control experiments which used no bolus or a saline bolus for treatment. Advantages of the model included ease of use and adaptability to test large numbers of materials. The model was suItable for in-vivo screening of platelet interactions with biomaterials placed in the bloodstream.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 331
Copyright
Copyright © Materials Research Society 1988

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