The Chemistry and Biology of Benz[a]anthracenes

M. S. Newman; B. Tierney; S. Veeraraghavan

doi:10.1017/CBO9780511753183

First published in 1988, this volume surveys the chemical synthesis and biological activity of the benz[a]anthracenes. These compounds occur in smoke and mineral oils and a few have been shown to be potent carcinogens. This volume was the first to review, systematically and in depth, the organic synthesis of these compounds as well as their metablolism, interactions with nucleic acids and protein, mutagenicity and carcinogenicity. Such studies have important implications in determining mechanism and specificity of chemically induced carcinogenesis.

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The Chemistry and Biology of Benz[a]anthracenes

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Contents

Frontmatter
pp i-iv

Contents
pp v-viii

Authors' preface
pp ix-x

Abbreviations employed in this book
pp xi-xiv

Part 1 - CHEMISTRY
pp 1-2

1 - Synthetic routes from benzenes and naphthalenes
pp 3-20

2 - Synthetic routes from anthracenes (A-ring formation)
pp 21-26

3 - Synthetic routes from phenanthrenes (D-ring formation)
pp 27-30

4 - Synthetic Diels–Alder routes to rings B and C
pp 31-36

5 - Miscellaneous synthetic routes
pp 37-48

6 - Tables
pp 49-62

7 - References to Part 1
pp 63-82

Part 2 - BIOLOGY
pp 83-86

8 - Metabolism
pp 87-112

9 - DNA, RNA and protein interactions
pp 113-143

10 - Mutagenicity
pp 144-159

11 - Carcinogenicity
pp 160-186

12 - References to Part 2
pp 187-210

Index to Parts 1 and 2
pp 211-228

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