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Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery

Published online by Cambridge University Press:  10 April 2019

F Mozzanica ,
A Preti ,
R Gera ,
C Bulgheroni ,
A Cardella ,
A Albera ,
F Collurà ,
N Mevio ,
A Dragonetti  and
A Schindler
...Show all authors
F Mozzanica
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
A Preti*
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
R Gera
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
C Bulgheroni
Affiliation:
Department of Otolaryngology, Desio Hospital, Monza, Italy
A Cardella
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
A Albera
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
F Collurà
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
N Mevio
Affiliation:
Department of Otolaryngology, Niguarda Hospital, Milan, Italy
A Dragonetti
Affiliation:
Department of Otolaryngology, Niguarda Hospital, Milan, Italy
A Schindler
Affiliation:
Department of Biochemical and Clinical Sciences, Sacco Hospital, University of Milan, Italy
U Milanesi
Affiliation:
Department of Otolaryngology, Desio Hospital, Monza, Italy
F Ottaviani
Affiliation:
Department of Clinical Sciences and Community Health, San Giuseppe Hospital, IRCCS Multimedica, University of Milan, Italy
*
Author for correspondence: Dr Andrea Preti, Department of Clinical Sciences and Community Health, Ospedale San Giuseppe, IRCCS Multimedica, University of Milan, Milan, Italy E-mail: andrea.preti87@gmail.com Fax: +39 0285 994 472
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Abstract

Objective

There is a growing interest in sodium hyaluronate for the clinical management of patients who undergo functional endoscopic sinus surgery for chronic rhinosinusitis, because of the mucosal regenerative properties of this macromolecule. However, its role in post-operative care is still debated. This study aimed to evaluate the effect of sodium hyaluronate administered via nasal irrigation with saline, in the post-operative period, after functional endoscopic sinus surgery.

Methods

A multicentric, prospective, randomised, double-blind, parallel group study was conducted on 56 consecutive patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without polyps. Group 1 received the standard therapy of normal saline; group 2 received saline plus sodium hyaluronate.

Results

Both objective and subjective measurements, in terms of endoscopic appearance and patient-reported satisfaction, were significantly better in group 2 compared to group 1.

Conclusion

Sodium hyaluronate may be a useful adjunct to nasal saline irrigation in the early post-operative period following functional endoscopic sinus surgery.

Keywords

SinusitisSurgeryNoseSodium Hyaluronate
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 4 , April 2019 , pp. 300 - 308
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr A Preti takes responsibility for the integrity of the content of the paper

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