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The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism

Published online by Cambridge University Press:  13 September 2016

VICKY L. HUNT ,
ISHENG J. TSAI ,
MURRAY E. SELKIRK  and
MARK VINEY
VICKY L. HUNT*
Affiliation:
School of Biological Sciences, Life Sciences Building, University of Bristol, Bristol BS8 1TQ, UK
ISHENG J. TSAI
Affiliation:
Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan
MURRAY E. SELKIRK
Affiliation:
Department of Life Sciences, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
MARK VINEY
Affiliation:
School of Biological Sciences, Life Sciences Building, University of Bristol, Bristol BS8 1TQ, UK
*
*Corresponding author: School of Biological Sciences, Life Sciences Building, University of Bristol, Bristol BS8 1TQ, UK. E-mail: v.l.hunt@bristol.ac.uk
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Summary

Parasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts. The recently sequenced genomes of four Strongyloides species, gastrointestinal parasites of humans and other animals, alongside transcriptomic and proteomic analysis of free-living and parasitic stages of their life cycles have revealed a number of protein families with a putative role in their parasitism. Many of these protein families have also been associated with parasitism in other parasitic nematode species, suggesting that these proteins may play a fundamental role in nematode parasitism more generally. Here, we review key protein families that have a putative role in Strongyloides’ parasitism – acetylcholinesterases, astacins, aspartic proteases, prolyl oligopeptidases, proteinase inhibitors (trypsin inhibitors and cystatins), SCP/TAPS and transthyretin-like proteins – and the evidence for their key, yet diverse, roles in the parasitic lifestyle.

Keywords

Strongyloideshelminthsacetylcholinesterasesastacinsaspartic proteasesprolyl oligopeptdasesproteinase inhibitorsSCP/TAPStransthyretin-like proteins
Type
Special Issue Review
Information
Parasitology , Volume 144 , Special Issue 3: Strongyloides , March 2017 , pp. 343 - 358
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Copyright
Copyright © Cambridge University Press 2016 

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