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Aberrant functional connectivity between reward and inhibitory control networks in pre-adolescent binge eating disorder

Published online by Cambridge University Press:  18 March 2022

Stuart B. Murray Open the ORCID record for Stuart B. Murray [Opens in a new window] ,
Celina Alba ,
Christina J. Duval ,
Jason M. Nagata ,
Ryan P. Cabeen ,
Darrin J. Lee ,
Arthur W. Toga ,
Steven J. Siegel  and
Kay Jann
Stuart B. Murray*
Affiliation:
Department of Psychiatry & Behavioral Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Celina Alba
Affiliation:
USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Christina J. Duval
Affiliation:
Department of Psychiatry & Behavioral Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Jason M. Nagata
Affiliation:
Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
Ryan P. Cabeen
Affiliation:
USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Darrin J. Lee
Affiliation:
Department of Psychiatry & Behavioral Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA
Arthur W. Toga
Affiliation:
USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Steven J. Siegel
Affiliation:
Department of Psychiatry & Behavioral Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
Kay Jann
Affiliation:
USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
*
Author for correspondence: Stuart B. Murray, E-mail: stuartmu@usc.edu, drstuartmurray@gmail.com
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Abstract

Background

Behavioral features of binge eating disorder (BED) suggest abnormalities in reward and inhibitory control. Studies of adult populations suggest functional abnormalities in reward and inhibitory control networks. Despite behavioral markers often developing in children, the neurobiology of pediatric BED remains unstudied.

Methods

58 pre-adolescent children (aged 9–10-years) with BED (mBMI = 25.05; s.d. = 5.40) and 66 age, BMI and developmentally matched control children (mBMI = 25.78; s.d. = 0.33) were extracted from the 3.0 baseline (Year 0) release of the Adolescent Brain Cognitive Development (ABCD) Study. We investigated group differences in resting-state functional MRI functional connectivity (FC) within and between reward and inhibitory control networks. A seed-based approach was employed to assess nodes in the reward [orbitofrontal cortex (OFC), nucleus accumbens, amygdala] and inhibitory control [dorsolateral prefrontal cortex, anterior cingulate cortex (ACC)] networks via hypothesis-driven seed-to-seed analyses, and secondary seed-to-voxel analyses.

Results

Findings revealed reduced FC between the dlPFC and amygdala, and between the ACC and OFC in pre-adolescent children with BED, relative to controls. These findings indicating aberrant connectivity between nodes of inhibitory control and reward networks were corroborated by the whole-brain FC analyses.

Conclusions

Early-onset BED may be characterized by diffuse abnormalities in the functional synergy between reward and cognitive control networks, without perturbations within reward and inhibitory control networks, respectively. The decreased capacity to regulate a reward-driven pursuit of hedonic foods, which is characteristic of BED, may in part, rest on this dysconnectivity between reward and inhibitory control networks.

Keywords

Binge eating disordereating disordersfunctional connectivityinhibitory controlpre-adolescent eating disordersreward sensitivity
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 9 , July 2023 , pp. 3869 - 3878
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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