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Relationship between symptom dimensions and white matter alterations in obsessive-compulsive disorder

Published online by Cambridge University Press:  13 September 2016

Michiyo Yagi ,
Yoshiyuki Hirano Open the ORCID record for Yoshiyuki Hirano [Opens in a new window] ,
Michiko Nakazato ,
Kiyotaka Nemoto Open the ORCID record for Kiyotaka Nemoto [Opens in a new window] ,
Kazuhiro Ishikawa ,
Chihiro Sutoh Open the ORCID record for Chihiro Sutoh [Opens in a new window] ,
Haruko Miyata ,
Junko Matsumoto ,
Koji Matsumoto  and
Yoshitada Masuda
...Show all authors
Michiyo Yagi
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan
Yoshiyuki Hirano*
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Michiko Nakazato
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan
Kiyotaka Nemoto
Affiliation:
Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Kazuhiro Ishikawa
Affiliation:
Ibaraki Prefectural Medical Center of Psychiatry, Kasama, Japan
Chihiro Sutoh
Affiliation:
Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Haruko Miyata
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan
Junko Matsumoto
Affiliation:
Department of Regional Disaster Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Koji Matsumoto
Affiliation:
Department of Radiology, Chiba University Hospital, Chiba, Japan
Yoshitada Masuda
Affiliation:
Department of Radiology, Chiba University Hospital, Chiba, Japan
Takayuki Obata
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Masaomi Iyo
Affiliation:
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
Eiji Shimizu
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Akiko Nakagawa
Affiliation:
Research Center for Child Mental Development, Chiba University, Chiba, Japan United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan
*
Yoshiyuki Hirano, Research Center for Child Mental Development, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Tel: +81-43-226-2975; Fax: +81-43-226-8588; E-mail: hirano@chiba-u.jp
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Abstract

Objective

To investigate the relationship between the severities of symptom dimensions in obsessive-compulsive disorder (OCD) and white matter alterations.

Methods

We applied tract-based spatial statistics for diffusion tensor imaging (DTI) acquired by 3T magnetic resonance imaging. First, we compared fractional anisotropy (FA) between 20 OCD patients and 30 healthy controls (HC). Then, applying whole brain analysis, we searched the brain regions showing correlations between the severities of symptom dimensions assessed by Obsessive-Compulsive Inventory-Revised and FA in all participants. Finally, we calculated the correlations between the six symptom dimensions and multiple DTI measures [FA, axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD)] in a region-of-interest (ROI) analysis and explored the differences between OCD patients and HC.

Results

There were no between-group differences in FA or brain region correlations between the severities of symptom dimensions and FA in any of the participants. ROI analysis revealed negative correlations between checking severity and left inferior frontal gyrus white matter and left middle temporal gyrus white matter and a positive correlation between ordering severity and right precuneus in FA in OCD compared with HC. We also found negative correlations between ordering severity and right precuneus in RD, between obsessing severities and right supramarginal gyrus in AD and MD, and between hoarding severity and right insular gyrus in AD.

Conclusion

Our study supported the hypothesis that the severities of respective symptom dimensions are associated with different patterns of white matter alterations.

Keywords

diffusion tensor imagingfractional anisotropyobsessive-compulsive disorderobsessive-compulsive inventory-revisedsymptom dimensions
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 29 , Issue 3 , June 2017 , pp. 153 - 163
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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