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Role of Frontotemporal Fiber Tract Integrity in Task-Switching Performance of Healthy Controls and Patients with Temporal Lobe Epilepsy

Published online by Cambridge University Press:  12 October 2011

N. Erkut Kucukboyaci ,
H.M. Girard ,
D.J. Hagler Jr. ,
J. Kuperman ,
E.S. Tecoma ,
V.J. Iragui ,
E. Halgren  and
C.R. McDonald
N. Erkut Kucukboyaci*
Affiliation:
Department of Psychiatry, University of California, San Diego, California Multimodal Imaging Laboratory, University of California, San Diego, California San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California
H.M. Girard
Affiliation:
Multimodal Imaging Laboratory, University of California, San Diego, California
D.J. Hagler Jr.
Affiliation:
Multimodal Imaging Laboratory, University of California, San Diego, California Department of Radiology, University of California, San Diego, California
J. Kuperman
Affiliation:
Multimodal Imaging Laboratory, University of California, San Diego, California
E.S. Tecoma
Affiliation:
Department of Neurosciences, University of California, San Diego, California
V.J. Iragui
Affiliation:
Department of Neurosciences, University of California, San Diego, California
E. Halgren
Affiliation:
Multimodal Imaging Laboratory, University of California, San Diego, California Department of Radiology, University of California, San Diego, California
C.R. McDonald
Affiliation:
Department of Psychiatry, University of California, San Diego, California Multimodal Imaging Laboratory, University of California, San Diego, California
*
Correspondence and reprint requests to: N. Erkut Kucukboyaci, Multimodal Imaging Laboratory, Suite C101; 8950 Villa La Jolla Drive, La Jolla, CA 92037. E-mail: erkut@ucsd.edu
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Abstract

The objective of this study is to investigate the relationships among frontotemporal fiber tract compromise and task-switching performance in healthy controls and patients with temporal lobe epilepsy (TLE). We performed diffusion tensor imaging (DTI) on 30 controls and 32 patients with TLE (15 left TLE). Fractional anisotropy (FA) was calculated for four fiber tracts [uncinate fasciculus (UncF), arcuate fasciculus (ArcF), dorsal cingulum (CING), and inferior fronto-occipital fasciculus (IFOF)]. Participants completed the Trail Making Test-B (TMT-B) and Verbal Fluency Category Switching (VFCS) test. Multivariate analyses of variances (MANOVAs) were performed to investigate group differences in fiber FA and set-shifting performances. Canonical correlations were used to examine the overall patterns of structural-cognitive relationships and were followed by within-group bivariate correlations. We found a significant canonical correlation between fiber FA and task-switching performance. In controls, TMT-B correlated with left IFOF, whereas VFCS correlated with FA of left ArcF and left UncF. These correlations were not significant in patients with TLE. We report significant correlations between frontotemporal fiber tract integrity and set-shifting performance in healthy controls that appear to be absent or attenuated in patients with TLE. These findings suggest a breakdown of typical structure-function relationships in TLE that may reflect aberrant developmental or degenerative processes. (JINS, 2012, 18, 57–67)

Keywords

Diffusion tensorUncinateCingulateFrontal lobeArcuateIFOF
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 1 , January 2012 , pp. 57 - 67
Copyright
Copyright © The International Neuropsychological Society 2011

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