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Rosmarinic acid: modes of action, medicinal values and health benefits

Published online by Cambridge University Press:  07 November 2017

Mahmoud Alagawany ,
Mohamed Ezzat Abd El-Hack ,
Mayada Ragab Farag ,
Marappan Gopi ,
Kumaragurubaran Karthik ,
Yashpal Singh Malik  and
Kuldeep Dhama
Mahmoud Alagawany*
Affiliation:
Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
Mohamed Ezzat Abd El-Hack
Affiliation:
Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
Mayada Ragab Farag
Affiliation:
Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Marappan Gopi
Affiliation:
Division of Avian Physiology and Reproduction, ICAR-Central Avian Research Institute, Izatnagar-243122, Uttar Pradesh, India
Kumaragurubaran Karthik
Affiliation:
Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India
Yashpal Singh Malik
Affiliation:
Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122 Uttar Pradesh, India
Kuldeep Dhama
Affiliation:
Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122 Uttar Pradesh, India
*
*Corresponding author. E-mail: mmalagwany@zu.edu.eg
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Abstract

The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic indices. Furthermore, RA reportedly reduces the risks of various animal diseases and mitigates side effects of chemical and synthetic drugs. RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive oxygen species induced in the body as a consequence of different kinds of stressors. Studies have further ascertained the capability of RA to work as an anti-microbial, immunomodulatory, anti-diabetic, anti-allergic, anti-inflammatory, hepato- and renal-protectant agent, as well as to have beneficial effects during skin afflictions. Additionally, RA is favored in meat industries due to enhancing the quality of meat products by reportedly improving shelf-life and imparting desirable flavor. This review describes the beneficial applications and recent findings with RA, including its natural sources, modes of action and various useful applications in safeguarding livestock health as well as important aspects of human health.

Keywords

Rosmarinic acidmode of actionbeneficial applicationhealth benefitsanimal
Type
Review Article
Information
Animal Health Research Reviews , Volume 18 , Special Issue 2: Antimicrobial resistance: from basic science to translational innovation , December 2017 , pp. 167 - 176
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Copyright © Cambridge University Press 2017 

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References

Abd El-Hack, ME, Mahgoub, SA, Alagawany, M and Dhama, K (2015). Influences of dietary supplementation of antimicrobial cold pressed oils mixture on growth performance and intestinal microflora of growing Japanese quails. International Journal of Pharmacology 11: 689–696.CrossRefGoogle Scholar
Alagawany, M and Abd El-Hack, ME (2015). The effect of rosemary herb as a dietary supplement on performance, egg quality, serum biochemical parameters, and oxidative status in laying hens. Journal of Animal and Feed Science 24: 341–347.CrossRefGoogle Scholar
Alkam, T, Nitta, A, Mizoguchi, H, Itoh, A and Nabeshima, T (2007). A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Aβ25–35. Behavioural Brain Research 180: 139–145.CrossRefGoogle Scholar
Baba, S, Osakabe, N, Natsume, M, Yasuda, A, Muto, Y, Hiyoshi, K, Takano, H, Yoshikawa, T and Terao, J (2005). Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. European Journal of Nutrition 44: 1–9.Google Scholar
Bacanli, M, Aydın, S, Taner, G, Göktaş, HG, Şahin, T, Başaran, AA and Başaran, N (2016). Does rosmarinic acid treatment have protective role against sepsis-induced oxidative damage in Wistar Albino rats? Human and Experimental Toxicology 35: 877–886.Google Scholar
Baluchnejadmojarad, T, Roghani, M and Kazemloo, P (2014). Rosmarinic acid mitigates learning and memory disturbances in amyloid β (25–35)-induced model of Alzheimer's disease in rat. Journal of Basic and Clinical Pathophysiology 2: 7–14.Google Scholar
Benedec, D, Hanganu, D, Oniga, I, Tiperciuc, B, Olah, NK, Raita, O, Bischin, C, Dumitrescu, RS and Vlase, L (2015). Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential. Pakistan Journal of Pharmaceutical Sciences 28: 2297–2303.Google ScholarPubMed
Boonyarikpunchai, W, Sukrong, S and Towiwat, P (2014). Antinociceptive and anti-inflammatory effects of rosmarinic acid isolated from Thunbergia laurifolia Lindl. Pharmacology Biochemistry and Behavior 124: 67–73.Google Scholar
Bulgakov, VP, Inyushkina, YV and Fedoreyev, SA (2012). Rosmarinic acid and its derivatives: biotechnology and applications. Critical Reviews in Biotechnology 32: 203–217.CrossRefGoogle ScholarPubMed
Chen, Q, Zhang, XH and Massagué, J (2011). Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20: 538–549.Google Scholar
Chun, KS, Kundu, J, Chae, IG and Kundu, JK (2014). Carnosol: a phenolic diterpene with cancer chemopreventive potential. Journal of Cancer Prevention 19: 103–110.Google Scholar
Chung, YC, Hsieh, FC, Lin, YJ, Wu, TY, Lin, CW, Lin, CT, Tang, NY and Jinn, TR (2015). Magnesium lithospermate B and rosmarinic acid, two compounds present in salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections. European Journal of Pharmacology 755: 127–133.CrossRefGoogle ScholarPubMed
Corral-Lugo, A, Daddaoua, A, Ortega, A, Espinosa-Urgel, M and Krell, T (2016). Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator. Science Signaling 9, ra1. doi: 10.1126/scisignal.aaa8271.Google Scholar
da Silva, SB, Ferreira, D, Pintado, M and Sarmento, B (2016). Chitosan-based nanoparticles for rosmarinic acid ocular delivery – in vitro tests. International Journal of Biological Macromolecules 84: 112–120.Google Scholar
Ekambaram, SP, Perumal, SS, Balakrishnan, A, Marappan, N, Gajendran, SS and Viswanathan, V (2016). Antibacterial synergy between rosmarinic acid and antibiotics against methicillin-resistant Staphylococcus aureus. Journal of Intercultural Ethnopharmacology 5: 358–363.Google Scholar
Ellis, BE and Towers, GHN (1970). Biogenesis of rosmarinic acid in Mentha. Biochemical Journal 118: 291–297.Google Scholar
Fadel, O, El Kirat, K and Morandat, S (2011). The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ. Biochimica et Biophysica Acta 1808: 2973–2980.CrossRefGoogle ScholarPubMed
Fallarini, S, Miglio, G and Paoletti, T (2009). Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. British Journal of Pharmacology 157: 1072–1084.Google Scholar
Farsi, A, Khaki, A, Fathiazad, F, Afshari, F, Hajhossini, L and Kahki, AA (2013). Improvement effect of rosmarinic acid on serum testosterone level after exposing with electromagnetic fields. International Journal of Women's Health and Reproduction Sciences 1: 45–50.CrossRefGoogle Scholar
Fernando, PM, Piao, MJ, Kang, KA, Ryu, YS, Hewage, SR, Chae, SW and Hyun, JW (2016). Rosmarinic acid attenuates cell damage against UVB radiation-induced oxidative stress via enhancing antioxidant effects in human HaCaT cells. Biomolecules & Therapeutics (Seoul) 24: 75–84.Google Scholar
Ferrández, A, Prescott, S and Burt, RW (2003). COX-2 and colorectal cancer. Current Pharmaceutical Design 9: 2229–2251.Google Scholar
Ferreira, LG, Celotto, AC, Capellini, VK, Albuquerque, AA, Nadai, TR, Carvalho, MT and Evora, PR (2013). Is rosmarinic acid underestimated as an experimental cardiovascular drug? Acta Cirurgica Brasileira 28: 83–87.CrossRefGoogle ScholarPubMed
Friedman, T (2015). The effect of rosmarinic acid on immunological and neurological systems: a basic science and clinical review. Journal of Restorative Medicine 4: 50–59.Google Scholar
Gao, LP, Wei, HL, Zhao, HS, Xiao, SY and Zheng, RL (2005). Antiapoptotic and antioxidant effects of rosmarinic acid in astrocytes. Pharmazie 60: 62–65.Google Scholar
Ghaffari, H, Venkataramana, M, Ghassam, BJ, Nayaka, SC, Nataraju, A, Geetha, NP and Prakash, HS (2014). Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells. Life Sciences 113: 7–13.CrossRefGoogle ScholarPubMed
Ghasemzadeh Rahbardar, M, Amin, B, Mehri, S, Mirnajafi-Zadeh, SJ and Hosseinzadeh, H (2017). Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacotherapy 86: 441–449.Google Scholar
Hajhosseini, L, Khaki, A, Merat, E and Ainehchi, N (2013). Effect of rosmarinic acid on sertoli cells apoptosis and serum antioxidant levels in rats after exposure to electromagnetic fields. African Journal of Traditional, Complementary and Alternative Medicines 10: 477–480.Google Scholar
Hasanein, P and Mahtaj, AK (2015). Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats. Neuroscience Letters 585: 23–27.Google Scholar
Hasanein, P and Zaheri, ML (2014). Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats. Pharmaceutical Biology 52: 1398–1402.Google Scholar
Hossain, MB, Rai, DK, Brunton, NP, Martin-Diana, AB and Barry-Ryan, C (2010). Characterization of phenolic composition in Lamiaceae species by LC-ESI-MS/MS. Journal of Agricultural and Food Chemistry 58: 10576–10581.CrossRefGoogle Scholar
Hossan, MS, Rahman, S, Anwarul Bashar, ABM, Jahan, R, Al-Nahain, A and Rahmatullah, M (2014). Rosmarinic acid: a review of its anticancer action. World Journal of Pharmaceutical Sciences 3: 57–70.Google Scholar
Hur, Y-G, Yun, Y and Won, J (2003). Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. Journal of Immunology 172: 79–87.Google Scholar
Inyushkina, YV, Bulgakov, VP, Veselova, MV, Bryukhanov, VM, Zverev, YF, Lampatov, VV, Azarova, OV, Tchernoded, GK, Fedoreyev, SA and Zhuravlev, YN (2007). High rabdosiin and rosmarinic acid production in Eritrichium sericeum callus cultures and the effect of the calli on masugi-nephritis in rats. Bioscience, Biotechnology, and Biochemistry 71: 1286–1293.Google Scholar
Jayanthy, G and Subramanian, S (2014). Rosmarinic acid, a polyphenol, ameliorates hyperglycemia by regulating the key enzymes of carbohydrate metabolism in high fat diet – STZ induced experimental diabetes mellitus. Biomedicine and Preventive Nutrition 4: 431–437.Google Scholar
Karthikkumar, V, Sivagami, G, Vinothkumar, R, Rajkumar, D and Nalini, N (2012). Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. Environmental Toxicology and Pharmacology 34: 949–958.Google Scholar
Karthikkumar, V, Sivagami, G, Viswanathan, P and Nalini, N (2015). Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats. Journal of Basic and Clinical Physiology and Pharmacology 26: 185–200.Google Scholar
Khaki, A, Imani, SAM and Golzar, F (2012). Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats. African Journal of Pharmacy and Pharmacology 6: 248–252.Google Scholar
Kim, GD, Park, YS, Jin, YH and Park, CS (2015). Production and applications of rosmarinic acid and structurally related compounds. Applied Microbiology and Biotechnology 99: 2083–2092.Google Scholar
Kim, SJ, Um, JY, Kim, SH and Hong, SH (2013). Protective effect of rosmarinic acid is through regulation of inflammatory cytokine in cadmium-induced ototoxicity. The American Journal of Chinese Medicine 41: 391–404.Google Scholar
Kuo, CF, Su, JD, Chiu, CH, Peng, CC, Chang, CH and Sung, TY (2011). Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves. Journal of Agricultural and Food Chemistry 59: 3674–3685.Google Scholar
Lee, HJ, Cho, HS, Park, E, Kim, S, Lee, SY, Kim, CS, Kim, DK, Kim, SJ and Chun, HS (2008). Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology 250: 109–115.Google Scholar
Lembo, S, Balato, A, Di Caprio, R, Cirillo, T, Giannini, V, Gasparri, F and Monfrecola, G (2014). The modulatory effect of ellagic acid and rosmarinic acid on ultraviolet-B-induced cytokine/chemokine gene expression in skin keratinocyte (HaCaT) cells. Biomed Research International 2014: 346793. doi: 10.1155/2014/346793.Google Scholar
Lin, M, Zhang, BX, Zhang, C, Shen, N, Zhang, YY, Wang, AX and Tu, CX (2014). Ginsenosides Rb1 and Rg1 stimulate melanogenesis in human epidermal melanocytes via PKA/CREB/MITF signaling. Evidence-based Complementary and Alternative Medicine 2014: 892073. doi: 10.1155/2014/892073.CrossRefGoogle ScholarPubMed
Luan, H, Kan, Z, Xu, Y, Lv, C and Jiang, W (2013). Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response. Journal of Neuroinflammation 10: 28.Google Scholar
Lucarini, R, Bernardes, WA, Ferreira, DS, Tozatti, MG, Furtado, R, Bastos, JK, Pauletti, PM, Januário, AH, Silva, ML and Cunha, WR (2013). In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative. Pharmaceutical Biology 51: 1087–1090.Google Scholar
Luño, V, Gil, L, Olaciregui, M, González, N, Jerez, RA and de Blas, I (2014). Rosmarinic acid improves function and in vitro fertilising ability of boar sperm after cryopreservation. Cryobiology 69: 157–162.Google Scholar
Madureira, AR, Nunes, S, Campos, DA, Fernandes, JC, Marques, C, Zuzarte, M, Gullón, B, Rodríguez-Alcalá, LM, Calhau, C, Sarmento, B, Gomes, AM, Pintado, MM and Reis, F (2016). Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches. International Journal of Nanomedicine 4: 3621–3640.Google Scholar
Makino, T, Ono, T, Muso, E, Yoshida, H, Honda, G and Sasayama, S (2000). Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells. Nephrology Dialysis Transplantation 15: 1140–1145.Google Scholar
McCue, P and Shetty, K (2004). Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asia Pacific Journal of Clinical Nutrition 13: 101–106.Google Scholar
Moreno, S, Scheyer, T, Romano, CS and Vojnov, AA (2006). Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radical Research 40: 223–231.Google Scholar
Mushtaq, N, Schmatz, R, Pereira, LB, Ahmad, M, Stefanello, N, Vieira, JM, Abdalla, F, Rodrigues, MV, Baldissarelli, J and Pelinson, LP (2014). Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats. Cell Biochemistry and Function 32: 287–293.Google Scholar
Nabavi, SF, Tenore, GC, Daglia, M, Tundis, R, Loizzo, MR and Nabavi, SM (2015). The cellular protective effects of rosmarinic acid: from bench to bedside. Current Neurovascular Research 2: 98–105.Google Scholar
Nakazawa, T and Ohsawa, K (1998). Metabolism of rosmarinic acid in rats. Journal of Natural Products 61: 993–996.CrossRefGoogle ScholarPubMed
Nakazawa, T and Ohsawa, K (2000). Metabolites of orally administered Perilla frutescens extract in rats and humans. Biological & Pharmaceutical Bulletin 23: 122–127.Google Scholar
Oh, H-A, Park, C-S, Ahn, H-J, Park, YS and Kim, H-M (2011). Effect of Perilla frutescens var. Acuta Kudo and rosmarinic acid on allergic inflammatory reactions. Experimental Biology and Medicine 236: 99–106.Google Scholar
Osakabe, N, Takano, H, Sanbongi, C, Yasuda, A, Yanagisawa, R, Inoue, K and Yoshikawa, T (2004). Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivities (SAR) and its mechanism. Biofactors 21: 127–131.Google Scholar
Ozturk, H, Ozturk, H, Terzi, EH, Ozgen, U, Duran, A and Uygun, I (2014). Protective effects of rosmarinic acid against renal ischaemia/reperfusion injury in rats. Journal Pakistan Medicine Association 64: 260–265.Google Scholar
Pereira, P, Tysca, D, Oliveira, P, da Silva Brum, LF, Picada, JN and Ardenghi, P (2005). Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacological Research 52: 199–203.Google Scholar
Pérez-Fons, L, Garzón, MT and Micol, V (2010). Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order. Journal of Agricultural and Food Chemistry 58: 161–171.Google Scholar
Petersen, M (2013). Rosmarinic acid: new aspects. Phytochemistry Reviews 12: 207–227.Google Scholar
Petersen, M and Simmonds, MSJ (2003). Rosmarinic acid. Photochemistry 62: 121–125.Google Scholar
Petersen, M, Abdullah, Y, Benner, J, Eberle, D, Gehlen, K, Hücherig, S, Janiak, V, Kim, KH, Sander, M, Weitzel, C and Wolters, S (2009). Evolution of rosmarinic acid biosynthesis. Phytochemistry 70: 1663–1679.Google Scholar
Petiwala, SM and Johnson, JJ (2015). Diterpenes from rosemary (Rosmarinus officinalis): defining their potential for anti-cancer activity. Cancer Letter 367: 93–102.Google Scholar
Rama Devi, K, Srinivasan, R, Kannappan, A, Santhakumari, S, Bhuvaneswari, M, Rajasekar, P, Prabhu, NM and Veera Ravi, A (2016). In vitro and in vivo efficacy of rosmarinic acid on quorum sensing mediated biofilm formation and virulence factor production in Aeromonas hydrophila. Biofouling 32: 1171–1183.CrossRefGoogle ScholarPubMed
Ramanauskiene, K, Raudonis, R and Majiene, D (2016). Rosmarinic acid and melissa officinalis extracts differently affect glioblastoma cells. Oxidative Medicine and Cellular Longevity 2016: 1564257. doi: 10.1155/2016/1564257.Google Scholar
Rice-Evans, CA, Miller, NJ and Paganga, G (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology and Medicine 20: 933–956.Google Scholar
Ritschel, WA, Starzacher, A, Sabouni, A, Hussain, AS and Koch, HP (1989). Percutaneous absorption of rosmarinic acid in the rat. Methods and Findings in Experimental and Clinical Pharmacology 11: 345–352.Google Scholar
Rocha, J, Eduardo-Figueira, M, Barateiro, A, Fernandes, A, Brites, D, Bronze, R, Duarte, CM, Serra, AT, Pinto, R and Freitas, M (2015). Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic and Clinical Pharmacology and Toxicology 116: 398–413.CrossRefGoogle Scholar
Rocío-Teruel, RM, Garrido, MD, Espinosa, MC and Linares, MB (2015). Effect of different format-solvent rosemary extracts (Rosmarinus officinalis) on frozen chicken nuggets quality. Food Chemistry 172: 40–46.CrossRefGoogle ScholarPubMed
Roland, CL, Dineen, SP, Toombs, JE, Carbon, JG, Smith, CW, Brekken, RA and Barnett, CC Jr (2010). Tumour-derived intercellular adhesion molecule-1 mediates tumour-associated leukocyte infiltration in orthotopic pancreatic xenografts. Experimental Biology and Medicine (Maywood) 235: 263–270.CrossRefGoogle Scholar
Rossi, F, Jullian, V, Pawlowiez, R, Kumar-Roiné, S, Haddad, M, Darius, HT, Gaertner-Mazouni, N, Chinain, M and Laurent, D (2012). Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin. Journal of Ethnopharmacology 143: 33–40.Google Scholar
Runtuwene, J, Cheng, KC, Asakawa, A, Amitani, H, Amitani, M, Morinaga, A, Takimoto, Y, Kairupan, BHR and Inui, A (2016). Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4. Journal of Drug Design, Development and Therapy 10: 2193–2202.Google Scholar
Sanbongi, C, Takano, H and Osakabe, N (2004). Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clinical and Experimental Allergy 34: 971–977.Google Scholar
Scarpati, ML and Oriente, G (1958). Isolamento e costituzione dell'acido rosmarinico (dal Rosmarinus off.). Ricerca Science 28: 2329–2333.Google Scholar
Scheckel, KA, Degner, SC and Romagnolo, DF (2008). Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and non-malignant cell lines. Journal of Nutrition 138: 2098–2105.CrossRefGoogle Scholar
Shekarchi, M, Hajimehdipoor, H, Saeidnia, S, Gohari, AR and Hamedani, MP (2012). Comparative study of rosmarinic acid content in some plants of Labiatae family. Pharmacognosy Magazine 8: 37–41.Google Scholar
Sotnikova, R, Okruhlicova, L, Vlkovicova, J, Navarova, J, Gajdacova, B, Pivackova, L, Fialova, S and Krenek, P (2013). Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta. Journal of Pharmacy and Pharmacology 65: 713–723.Google Scholar
Stansbury, J (2014). Rosmarinic acid as a novel agent in the treatment of allergies and asthma. Journal of Restorative Medicine 3: 121–126.Google Scholar
Swarup, V, Ghosh, J, Ghosh, S, Saxena, A and Basu, A (2007). Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis. Antimicrobial Agents and Chemotherapy 51: 3367–3370.Google Scholar
Tao, L, Wang, S, Zhao, Y, Sheng, X, Wang, A, Zheng, S and Lu, Y (2014). Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. Phytomedicine 21: 1473–1482.CrossRefGoogle ScholarPubMed
Tavafi, M, Ahmadvand, H, Khalatbari, A and Tamjidipoor, A (2010). Rosmarinic acid ameliorates diabetic nephropathy in uninephrectomized diabetic rats. Iranian Journal of Basic Medical Sciences 14: 275–283.Google Scholar
Tsai, TH, Chuang, LT, Lien, TJ, Liing, YR, Chen, WY and Tsai, PJ (2013). Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. Journal of Medicinal Food 16: 324–333.Google Scholar
Uyeturk, U, Firat, T, Cetinkaya, A, Kin Tekce, B and Cakir, S (2014). Protective effects of rosmarinic acid on doxorubicin-induced testicular damage. Chemotherapy 60: 7–12.Google Scholar
Venkatachalam, K, Gunasekaran, S, Jesudoss, VA and Namasivayam, N (2013). The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis. Experimental and Toxicologic Pathology 65: 409–418.CrossRefGoogle ScholarPubMed
Venkatachalam, K, Gunasekaran, S and Namasivayam, N (2016). Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer. European Journal of Pharmacology 791: 37–50.CrossRefGoogle Scholar
Vladimir-Knežević, S, Blažeković, B, Kindl, M, Vladić, J, Lower-Nedza, AD and Brantner, AH (2014). Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family. Molecules 19: 767–782.Google Scholar
Wilcox, G (2005). Insulin and insulin resistance. The Clinical Biochemist Reviews 26: 19–39.Google ScholarPubMed
Won, J, Hur, YG, Hur, EM, Park, SH, Kang, MA and Choi, Y (2003). Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner. European Journal of Immunology 33: 870–879.Google Scholar
Wu, CF, Hong, C, Klauck, SM, Lin, YL and Efferth, T (2015). Molecular mechanisms of rosmarinic acid from salvia miltiorrhiza in acute lymphoblastic leukemia cells. Journal of Ethnopharmacology 176: 55–68.Google Scholar
Xu, W, Yang, F, Zhang, Y and Shen, X (2016). Protective effects of rosmarinic acid against radiation-induced damage to the hematopoietic system in mice. Journal of Radiation Research 57: 356–362.Google Scholar
Yesilbag, D, Eren, M, Agel, H, Kovanlikaya, A and Balci, F (2011). Effects of dietary rosemary, rosemary volatile oil and vitamin E on broiler performance, meat quality and serum SOD activity. British Poultry Science 52: 472–482.Google Scholar
Yesil-Celiktas, O, Sevimli, C, Bedir, E and Vardar-Sukan, F (2010). Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods and Human Nutrition 65: 158–163.Google Scholar
Youn, J, Lee, KH and Won, J (2003). Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis. The Journal of Rheumatology 30: 1203–1207.Google Scholar
Zhang, JJ, Wang, YL, Feng, XB, Song, XD and Liu, WB (2011). Rosmarinic acid inhibits proliferation and induces apoptosis of hepatic stellate cells. China Biological & Pharmaceutical Bulletin 34: 343–348.Google Scholar
Zhang, Y, Chen, X, Yang, L, Zu, Y and Lu, Q (2015). Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice. Food Function 6: 927–931.Google Scholar
Zhu, F, Asada, T, Sato, A, Koi, Y, Nishiwaki, H and Tamura, H (2014). Rosmarinic acid extract for antioxidant, antiallergic and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from perilla leaves. Journal of Agricultural and Food Chemistry 62: 885–892.Google Scholar
Zhu, F, Xu, Z, Yonekura, L, Yang, R and Tamura, H (2015). Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity, and bulkiness of alkyl side chain. Bioscience, Biotechnology, and Biochemistry 79: 1178–1182.Google Scholar