D. C. Matthew makes an important contribution to the ongoing debate between integrationists and their critics. While Matthew's conclusion that blacks have a duty not to integrate is too strong, his account provides additional reasons why they may not want to integrate. Further reasons to resist integration may be provided by considering the contexts of integration, particularly with respect to the degree of coerciveness that they involve. I argue that resistance to integration should take the form of not only refusing to participate in it but also of engaging in collective political action in the pursuit of racial justice.

Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body’s natural defense system loses discriminating power between its own cells and foreign cells, causing the body to mistakenly attack healthy tissues. These conditions are very heterogeneous in their presentation and therefore difficult to diagnose and treat. Achieving precision medicine in autoimmune diseases has been challenging due to the complex etiologies of these conditions, involving an interplay between genetic, epigenetic, and environmental factors. However, recent technological and computational advances in molecular profiling have helped identify patient subtypes and molecular pathways which can be used to improve diagnostics and therapeutics. This review discusses the current understanding of the disease mechanisms, heterogeneity, and pathogenic autoantigens in autoimmune diseases gained from genomic and transcriptomic studies and highlights how these findings can be applied to better understand disease heterogeneity in the context of disease diagnostics and therapeutics.

For both John Stuart Mill and Wilhelm von Humboldt, self–development is a central value that shapes much of their respective political philosophies. Despite this shared value, however, Mill and Humboldt came to quite different political conclusions. Mill defends an activist state that helps establish the material and institutional prerequisites for self–development, while Humboldt argues for a highly restricted state that provides only security. This divergence is explained by a number of factors: variations in their conceptions of self–development itself; their different views of the empirical prerequisites of self–development; their different views of the state and its relation to society; and their views of the relation between “positive” and “negative” goods.

This article brings together work on liberal political theory and black nationalism in an attempt to both strengthen the case for black nationalism and enrich and extend liberal theory. I begin by arguing that for much of U.S. history, the classical black nationalist case for an independent state finds substantial support in recent liberal theories of secession. In the post–civil rights era, black nationalists in the Black Power movement argued for more limited forms of black autonomy, a position known as “community nationalism.” Community black nationalism makes claims similar to minority nationalist claims for limited self-determination, yet liberal multiculturalists like Will Kymlicka defend the latter while withholding support for black nationalism. I argue that black nationalism raises fundamental issues of justice and that liberal multicultural theory can be extended to support black nationalist claims.

The Antikythera Mechanism is the most sophisticated extant ancient astronomical instrument and analogue computer known and was assembled sometime between 150 and 100 BCE, almost a century after the death of Archimedes. The mechanism has a great educational potential as it appeals to inquiring minds as an astonishing artefact of science and technology. The latest research findings reveal significant cultural and social functions in its operations. This astonishing astronomical instrument has a clear interdisciplinary valueand it has that it may be used as an educational medium, to engage the general public, and especially to attract students both to/from exact sciences and to/from the humanities. The astronomical and technical knowledge embedded in the mechanism can also be used to introduce some aspects of modern science through the unknown technological achievements of Hellenic antiquity.

Peter Meilaender has written one of the only single-author books on the ethics of immigration policy, and perhaps the only one that defends the position that “states are entitled, within certain wide limits, to craft immigration policies as they see fit” (p. 1). Most normative work on immigration, as he notes, supports the position that states are more ethically constrained in making immigration policy, much of it arguing for an “open borders” policy. As such, his book may serve as a useful point of reference in the debate over immigration policy.

The ESEN (European Sero-Epidemiology Network) project was established to harmonize the seroepidemiology of five vaccine preventable infections including measles, mumps and rubella in eight European countries. This involved achieving comparability both in the assay results from testing in different centres and also sampling methodology. Standardization of enzyme immunoassay results was achieved through the development of common panels of sera by designated reference centres. The panels were tested at the reference laboratory and then distributed to each participating laboratory for testing using their routine methods. Standardization equations were calculated by regressing the quantitative results against those of the reference laboratory. Our study found large differences in unitage between participants, despite all using an EIA method standardized against an international or local standard. Moreover, our methodology adjusted for this difference. These standardization equations will be used to convert the results of main serosurvey testing into the reference country unitage to ensure inter-country comparability.