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Although amniocentesis was first reported in 1882, the technique was not in widespread clinical practice until the 1970's. The reason for this slow uptake was that there were few indications for performing the procedure until fetal karyotyping from amniotic fluid cells became possible in 1966. Currently fetal karyotyping is the commonest indication for the technique and amniocentesis has become the mainstay of antenatal diagnosis.
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