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The savannah–forest mosaic of the Rupununi region of Guyana is a dispersal corridor between large tracts of intact Guiana Shield forests and a subsistence hunting ground for Indigenous Makushi and Wapichan communities. We conducted a camera-trap survey at 199 sites across four major forested habitat types and used multi-species occupancy modelling to determine regional-scale drivers of mammalian occupancy at both species and community levels, accounting for imperfect detection. We detected 47 savannah- and forest-dwelling mammal species, with the occupancy of medium- and large-bodied terrestrial mammal species (community occupancy) positively related to per cent forest cover and negatively to the presence of gallery forest habitat. The occupancy of 15 of 30 species was positively related to forest cover, suggesting the importance of maintaining forested habitat within the broader mosaic comprising savannahs and intermediate habitats for sustaining maximum mammal diversity. Jaguar Panthera onca occupancy was associated with the presence of livestock, and giant anteater Myrmecophaga tridactyla occupancy was negatively associated with distance to the nearest road, both results of concern in relation to potential human–wildlife conflict. The probability of detecting terrestrial mammal species (community detectability) increased away from villages, as did the detectability of two large-bodied, hunted species, the lowland tapir Tapirus terrestris and collared peccary Pecari tajacu, potentially indicating the negative effects of subsistence and commercial hunting in this savannah mosaic habitat. We use our findings to discuss how management strategies for hunting, fire, timber harvest and agriculture within Indigenous titled lands could help ensure the sustainability of these traditional livelihood activities.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Heath forests, or known locally as kerangas, in Indonesia and Malaysia form a distinct and understudied ecoregion. We document the distribution and ecological significance of the largest extent of kerangas in Kalimantan, Indonesian Borneo. We mapped 16,586 km2 of kerangas to the nearest one square kilometre across Kalimantan, showing a significant reduction from previous estimates. About 19% of this area exists as a poorly documented mosaic landscape in Central Kalimantan’s Rungan-Kahayan region. Here, peat-based forests transition to heath and dipterocarp forests, making it difficult to reliably classify these forests for conservation planning. Using remote sensing and tree plot data, we identified three forest types—kerangas, low pole, and mixed swamp. Vegetation structure is influenced by soil, topography, and hydrology, while peat depth and elevation affect species diversity. Our findings indicate that these forests are dynamic ecosystems with diverse vegetation communities adapted to peat as well as sandy soils. Lowland heath forests in Rungan-Kahayan exhibits higher tree densities compared to other Bornean heath forests, reflecting unique ecological adaptations to challenging environments. Despite covering just 3% of Kalimantan’s forest area, these ecosystems remain largely unprotected, facing threats from land conversion and fire. Our study highlights the ecological complexity of kerangas and underscores the urgent need for targeted conservation and further research on these forests.
Comprehend, Cope and Connect (CCC) is a trauma-informed, transdiagnostic and evidence-based psychological intervention for mental health crises that can be applied cross-culturally. CCC has been implemented in acute and crisis mental health settings across the South of England and in services elsewhere in the UK. More recently, it has been taken up and adapted for specialist community settings, including perinatal services, addiction services and primary care settings. A continuously growing evidence base indicates that CCC could be the next step towards solving the national problem of mental health crises. It is now time for CCC to be piloted and researched nationally.
The First Large Absorption Survey in H i (FLASH) is a large-area radio survey for neutral hydrogen in and around galaxies in the intermediate redshift range $0.4\lt z\lt1.0$, using the 21-cm H i absorption line as a probe of cold neutral gas. The survey uses the ASKAP radio telescope and will cover 24,000 deg$^2$ of sky over the next five years. FLASH breaks new ground in two ways – it is the first large H i absorption survey to be carried out without any optical preselection of targets, and we use an automated Bayesian line-finding tool to search through large datasets and assign a statistical significance to potential line detections. Two Pilot Surveys, covering around 3000 deg$^2$ of sky, were carried out in 2019-22 to test and verify the strategy for the full FLASH survey. The processed data products from these Pilot Surveys (spectral-line cubes, continuum images, and catalogues) are public and available online. In this paper, we describe the FLASH spectral-line and continuum data products and discuss the quality of the H i spectra and the completeness of our automated line search. Finally, we present a set of 30 new H i absorption lines that were robustly detected in the Pilot Surveys, almost doubling the number of known H i absorption systems at $0.4\lt z\lt1$. The detected lines span a wide range in H i optical depth, including three lines with a peak optical depth $\tau\gt1$, and appear to be a mixture of intervening and associated systems. Interestingly, around two-thirds of the lines found in this untargeted sample are detected against sources with a peaked-spectrum radio continuum, which are only a minor (5–20%) fraction of the overall radio-source population. The detection rate for H i absorption lines in the Pilot Surveys (0.3 to 0.5 lines per 40 deg$^2$ ASKAP field) is a factor of two below the expected value. One possible reason for this is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper in this series will discuss the host galaxies of the H i absorption systems identified here.
The health benefits of the long-chain omega-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been known for over 50 years and underpin the UK population recommendation to consume >450 mg EPA + DHA per day. These recommendations, last revised in 2004, are based mainly on epidemiological evidence. Much research has been conducted in the interim. Most randomised controlled trials (RCT) use doses of EPA + DHA of 840 mg/d or more. For anti-inflammatory, triacylglycerol-lowering and anti-hypertensive effects, >1.5 g EPA + DHA per day is needed. Cognitive benefits are also likely to require these higher intakes. Farmed salmon now contains considerably less EPA + DHA relative to farmed fish of 20 years ago, meaning one portion per week will no longer provide the equivalent of 450 mg EPA + DHA per day. Oily fish alone can only provide a fraction of the EPA + DHA required to meet global needs. Furthermore, there is low global oily fish consumption, with typical intakes of <200 mg EPA + DHA per day, and limited intakes in vegans and vegetarians. Therefore, there is an urgent need for affordable, acceptable, alternative EPA + DHA sources, including vegan/vegetarian friendly options, such as bio-enriched poultry, red meat and milk products; fortified foods; enriched oilseeds (for example, genetically modified Camelina sativa); algae and algal oils; and approaches which enhance endogenous EPA/DHA synthesis. In this narrative review, we suggest that current EPA + DHA intake recommendations are too low, consider EPA/DHA from a holistic health-sustainability perspective and identify research, policy and knowledge mobilisation areas which need attention.
The structure of psychopathology can be organized hierarchically into a set of transdiagnostic dimensional phenotypes. No studies have examined whether these phenotypes are associated with brain structure or dementia in older adults.
Methods
Data were drawn from a longitudinal study of older adults aged 70–90 years at baseline (N = 1072; 44.8% male). Confirmatory factor models were fit to baseline psychiatric symptoms, with model fit assessed via traditional fit indices, model-based reliability estimates, and evaluation of model parameters. Bayesian plausible values were generated from the best-fitting model for use in subsequent analyses. Linear mixed models examined intraindividual change in global and regional gray matter volume (GMV) and cortical thickness over 6 years. Logistic regression examined whether symptom dimensions predicted incident dementia over 12 years.
Results
A higher-order model showed a good fit to the data (BIC = 28,691.85; ssaBIC = 28,396.47; CFI = 0.926; TLI = 0.92; RMSEA = 0.047), including a general factor and lower-order dimensions of internalizing, disinhibited externalizing, and substance use. Baseline symptom dimensions did not predict change over time in total cortical and subcortical GMV or average cortical thickness; regional GMV or cortical thickness in the frontal, parietal, temporal, or occipital lobes; or regional GMV in the hippocampus and cerebellum (all p-values >0.5). Finally, baseline symptom dimensions did not predict incident dementia across follow-ups (all p-values >0.5).
Conclusions
We found no evidence that transdiagnostic dimensions are associated with gray matter structure or dementia in older adults. Future research should examine these relationships using psychiatric indicators capturing past history of chronic mental illness rather than current symptoms.
The authors report on ancient DNA data from two human skeletons buried within the chancel of the 1608–1616 church at the North American colonial settlement of Jamestown, Virginia. Available archaeological, osteological and documentary evidence suggest that these individuals are Sir Ferdinando Wenman and Captain William West, kinsmen of the colony's first Governor, Thomas West, Third Baron De La Warr. Genomic analyses of the skeletons identify unexpected maternal relatedness as both carried the mitochondrial haplogroup H10e. In this unusual case, aDNA prompted further historical research that led to the discovery of illegitimacy in the West family, an aspect of identity omitted, likely intentionally, from genealogical records.
Several factors shape the neurodevelopmental trajectory. A key area of focus in neurodevelopmental research is to estimate the factors that have maximal influence on the brain and can tip the balance from typical to atypical development.
Methods
Utilizing a dissimilarity maximization algorithm on the dynamic mode decomposition (DMD) of the resting state functional MRI data, we classified subjects from the cVEDA neurodevelopmental cohort (n = 987, aged 6–23 years) into homogeneously patterned DMD (representing typical development in 809 subjects) and heterogeneously patterned DMD (indicative of atypical development in 178 subjects).
Results
Significant DMD differences were primarily identified in the default mode network (DMN) regions across these groups (p < 0.05, Bonferroni corrected). While the groups were comparable in cognitive performance, the atypical group had more frequent exposure to adversities and faced higher abuses (p < 0.05, Bonferroni corrected). Upon evaluating brain-behavior correlations, we found that correlation patterns between adversity and DMN dynamic modes exhibited age-dependent variations for atypical subjects, hinting at differential utilization of the DMN due to chronic adversities.
Conclusion
Adversities (particularly abuse) maximally influence the DMN during neurodevelopment and lead to the failure in the development of a coherent DMN system. While DMN's integrity is preserved in typical development, the age-dependent variability in atypically developing individuals is contrasting. The flexibility of DMN might be a compensatory mechanism to protect an individual in an abusive environment. However, such adaptability might deprive the neural system of the faculties of normal functioning and may incur long-term effects on the psyche.
A quaternary ammonium and alcohol-based disinfectant with reported continuous activity demonstrated reduced microbial buildup on surfaces over time compared to routine disinfectants without continuous activity in in vitro and hospital studies. We compared these disinfectants in ambulatory settings and found no difference in bioburden on high-touch surfaces over time.
This comprehensive literature scoping review outlines available infection prevention and control (IPC) methods for viral-mediated gene therapies and provides one IPC strategy for the healthcare setting based on a single-center recommendation.
Methods:
A team of experts in pharmacy, healthcare epidemiology, and biosafety with experience in viral-mediated gene therapy was assembled within a pediatric hospital to conduct a comprehensive literature scoping review. The comprehensive review included abstracts and full-text articles published since 2009 and utilized prespecified search terms of the five viral vectors of interest: adenovirus (AV), retrovirus (RV), adeno-associated virus (AAV), lentivirus (LV), and herpes simplex virus (HSV). Case reports, randomized controlled trials, and bench research studies were all included, while systematic reviews were excluded.
Results:
A total of 4473 case reports, randomized control trials, and benchtop research studies were identified using the defined search criteria. Chlorine compounds were found to inactivate AAV and AV, while alcohol-based disinfectants were ineffective. There was a relative paucity of studies investigating surface-based disinfection for HSV, however, alcohol-based disinfectants were effective in one study. Ultraviolent irradiation was also found to inactivate HSV in numerous studies. No studies investigated disinfection for LV and RV vectors.
Conclusions:
The need to define IPC methods is high due to the rapid emergence of viral-mediated gene therapies to treat rare diseases, but published clinical guidance remains scarce. In the absence of these data, our center recommends a 1:10 sodium hypochlorite solution in clinical and academic environments to ensure complete germicidal activity of viral-mediated gene therapies.
This book reflects on what people in two different Colombian communities have achieved through participatory peacebuilding. The authors explore different forms of local agency, the prospects for non-extractive academic engagement, and practical and theoretical lessons for participating in peace in other conflict-affected settings.
We recently reported on the radio-frequency attenuation length of cold polar ice at Summit Station, Greenland, based on bi-static radar measurements of radio-frequency bedrock echo strengths taken during the summer of 2021. Those data also allow studies of (a) the relative contributions of coherent (such as discrete internal conducting layers with sub-centimeter transverse scale) vs incoherent (e.g. bulk volumetric) scattering, (b) the magnitude of internal layer reflection coefficients, (c) limits on signal propagation velocity asymmetries (‘birefringence’) and (d) limits on signal dispersion in-ice over a bandwidth of ~100 MHz. We find that (1) attenuation lengths approach 1 km in our band, (2) after averaging 10 000 echo triggers, reflected signals observable over the thermal floor (to depths of ~1500 m) are consistent with being entirely coherent, (3) internal layer reflectivities are ≈–60$\to$–70 dB, (4) birefringent effects for vertically propagating signals are smaller by an order of magnitude relative to South Pole and (5) within our experimental limits, glacial ice is non-dispersive over the frequency band relevant for neutrino detection experiments.
Primary youth mental health services in Australia have increased access to care for young people, yet the longer-term outcomes and utilisation of other health services among these populations is unclear.
Aims
To describe the emergency department presentation patterns of a help-seeking youth mental health cohort.
Method
Data linkage was performed to extract Emergency Department Data Collection registry data (i.e. emergency department presentations, pattern of re-presentations) for a transdiagnostic cohort of 7024 youths (aged 12–30 years) who presented to mental health services. Outcome measures were pattern of presentations and reason for presentations (i.e. mental illness; suicidal behaviours and self-harm; alcohol and substance use; accident and injury; physical illness; and other).
Results
During the follow-up period, 5372 (76.5%) had at least one emergency department presentation. The presentation rate was lower for males (IRR = 0.87, 95% CI 0.86–0.89) and highest among those aged 18 to 24 (IRR = 1.117, 95% CI 1.086–1.148). Almost one-third (31.12%) had an emergency department presentation that was directly associated with mental illness or substance use, and the most common reasons for presentation were for physical illness and accident or injury. Index visits for mental illness or substance use were associated with a higher rate of re-presentation.
Conclusions
Most young people presenting to primary mental health services also utilised emergency services. The preventable and repeated nature of many presentations suggests that reducing the ongoing secondary risks of mental disorders (i.e. substance misuse, suicidality, physical illness) could substantially improve the mental and physical health outcomes of young people.
Coconut farming contributes to the livelihoods of millions of people in tropical countries but is less frequently considered as a threat to biodiversity compared to other palm commodities such as oil palm. The expansion of coconut farming alongside other smallholder agriculture in Sulawesi, Indonesia, is of potential concern as the region is a centre of species endemism. We studied bird diversity and community structure in forests, coconut palm plantations and mixed farmland in Gorontalo Province, northern Sulawesi. Forest and non-forest sites supported similar numbers of species overall, but compared to agricultural areas, forest sites had communities that were more diverse and more even (i.e. different species were present at similar abundances). We found far fewer endemic species in agricultural areas compared to forests, and the communities in palm plantations and mixed farmland sites were dominated by generalist birds, with few indicator taxa. Nevertheless, there was a higher number of endemic species in coconut palm plantations than in mixed farmland sites. These findings mirror patterns of biotic homogenization documented elsewhere in the Wallacea centre of endemism, and imply that coconut palm plantations have comparable biodiversity value to other farmland systems. Increased protection of lowland forests and improved management of coconut farms could be important for supporting the conservation of the endemic birds of Sulawesi in the long term, but this warrants further study.
In August 2022, Colombians elected, for the first time, a left-leaning government. Led by former guerrilla activist Gustavo Petro and his Vice President Francia Márquez, an Afro-Colombian woman and well-known advocate for human rights and environmental justice, the shift in governmental discourse was immediately striking. President Petro used his inauguration speech to promise that he would deliver Paz total (total peace), which would involve entering into talks with a wide range of armed groups to tackle the violence that has continued – indeed, in some areas has increased – in the years since the peace agreement between the government and the Fuerzas Armadas Revolucionarias de Colombia (Revolutionary Armed Forces of Colombia; FARC) was signed in 2016. Essential to total peace would be not only those new negotiations, but also fully implementing the terms of the 2016 agreement itself. Former President Iván Duque's (2018–22) failure to do so had caused widespread disillusionment with the peace process, and had also spurred splinter groups from the FARC to continue in arms.
Hopes for a stable and lasting peace in Colombia will depend in part on Petro's success in persuading the wide range of guerrilla, paramilitary and criminal groups still active in the country to cease the violence and lay down their weapons. But Petro was clear that total peace would also need to be a project for the whole of society:
For peace to be possible in Colombia we need dialogue, a lot of dialogue, to understand each other, seek common paths, and produce change … Our future is not written. We own the pen and we can write the page together, in peace and togetherness. Today, we start the Colombia of the possible.
(Petro, quoted in Emblin, 2022)
This book is interested in how, in the years before and since the 2016 peace agreement, communities have been using dialogue as a way of participating in the building of peace, often in relatively unpromising circumstances. Seeking to understand the dynamics of community-level dialogues that aim to deal with the legacies of earlier violence and overcome ongoing conflicts, the book takes a ‘bottom-up’ look at the building of peace.
The 2016 Colombian peace agreement was lauded internationally as innovative, multi-layered and comprehensive. It went far beyond a simple commitment to lay down arms, incorporating further provisions on how to deal with various thorny legacies of the conflict, and also new challenges that would arise in response to its implementation. These included issues such as reparations for victims and the reintegration of demobilized FARC combatants, including guarantees for their political participation. Most ambitiously, the agreement sought to provide for the future economic growth of the predominantly rural areas that had been most heavily impacted by the conflict, often among the poorest in the country. In doing so, it incorporated much of the learning from previous peace processes (both those perceived as successful and those less so) that took place around the world in the post-Cold War era, while building upon multiple peacebuilding experiences and traditions developed in Colombia itself over the preceding decades. This unquestionably ambitious project of a participatory peace and geographically targeted development was, nevertheless, criticized widely from within Colombia. In the areas that were ostensibly intended to benefit from it, various social actors pointed to an implementation process that failed to address asymmetric power relations and, above all, the economic injustices that fuelled the armed conflict in the first place.
The discussion in this chapter situates the emergence of new forms of community-led participatory peacebuilding in relation to shortcomings in the peace process. Specifically, the chapter's goal is to contextualize the origins of the diálogos socio-territoriales (DSTs) discussed in Chapter Two and explored empirically in Chapters Three and Four. Particularly notable in the Colombian peace process was the government's use of social dialogue as a form of state-sponsored participatory peacebuilding, which in turn built upon previous civil society-led experiments with peace. The ambitious peace programme aspired to produce peaceful and prosperous futures for conflict-affected areas while involving the entirety of Colombian society in the process. However, it was also rather top-down in its initial composition, and various state–society interactions occurred during both the negotiation and implementation phases, which saw its very constitution and purpose becoming a site of conflict and contestation.
This book has been inspired by two central questions. First, how are communities in Colombia seizing the initiative to build peace in the wake of the historic 2016 peace agreement? And second, what can participatory research contribute to these efforts, both within and beyond Colombia?
As is the case with any project in such a complex and shifting social and political situation, the findings we present and discuss here are necessarily provisional and partial. Colombia's conflict, the changing local and national politics surrounding it and associated efforts to understand and reduce violence – efforts that include local actors, NGOs, governments, international agencies and the research community alike – continue to evolve with dizzying speed. A meaningful or comprehensive peace in Colombia is a long way from being successfully ‘built’. Yet notwithstanding the limitations of our own efforts, we are confident of the significant untapped potential for engaged, immersive and non-extractive research in ‘post-conflict’ scenarios and, however embryonic and limited they may be, it is plainly evident that many communities beyond those we have examined here are constantly engaged in the careful, gradual and difficult business of constructing their own visions of more peaceful lives and futures.
In this concluding chapter, we present a synthesis of the book's central empirical, theoretical and methodological insights. We begin by placing the key findings from the two empirical cases in dialogue with one another and in relation to the wider story of the Colombian peace process, including the ‘territorial peace’ agenda. Here we return to the book's core concept of DST and ask what potential lessons these experiences can offer for other community-based actors. In the second section, we outline our key reflections for peace scholars and practitioners, making the case that DST is not only a descriptive concept describing a particular form of dialogue practice, but also a normative one which provides an entry point for PAR-based research to play a meaningful role in partnering with and supporting communities within and beyond Colombia to overcome the conflict(s) that inhibit their ability to live with dignity. Finally, we offer a brief analysis of recent events in Colombia, specifically the election of President Petro in 2022, and the implications of his early efforts towards a lasting form of ‘total peace’.