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A probabilistic, multidimensional version of Coombs' unfolding model is obtained by assuming that the projections of each stimulus and each individual on each axis are normally distributed. Exact equations are developed for the single dimensional case and an approximate one for the multidimensional case. Both types of equations are expressed solely in terms of univariate normal distribution functions and are therefore easy to evaluate. A Monte Carlo experiment, involving 9 stimuli and 3 subjects in a 2 dimensional space, was run to determine the degree of accuracy of the multidimensional equation and the feasibility of using iterative methods to obtain maximum likelihood estimates of the stimulus and subject coordinates. The results reported here are gratifying in both respects.
Peanut (Arachis hypogaea L.) and maize (Zea mays L.) are essential crops for Ghana’s economy and food security, but weed infestation poses a significant threat to their cultivation. Crop rotations influence weed communities, but little is known about these processes in peanut-cropping systems in West Africa. This study investigated the impact of different crop rotations and input levels on weed communities in Ghana over 3 yr. Results showed that low inputs (absence of herbicide and fertilization) favored species richness, while higher input levels (weed control with herbicides and fertilizer use) reduced it. Diversity and evenness were also affected by inputs, with varying patterns across locations and seasons. Weed population growth rates (λ) varied significantly by location and treatment; all management programs resulted in increasing weed populations. Principal component analysis revealed distinct associations between weed species and crop management. The majority of weed species exhibited a generalist behavior and did not associate with a particular management. However, billygoat weed (Ageratum conyzoides L.) and Benghal dayflower (Commelina benghalensis L.) were positively associated with high-input systems, while purple nutsedge (Cyperus rotundus L.) exhibited strong associations with low and medium inputs. The weed–crop rotation dynamics described here demonstrate how management drives the selection of weed species that are more pervasive and interfere with important food crops in Ghanaian agriculture.
Currently utilized clinician-rated symptom scales for tardive dyskinesia (TD) have not kept up with the expanding spectrum of TD phenomenology. The objective of this study was to develop and test the reliability of a new instrument, the CTI.
Methods
A movement disorder neurologist devised the outline of the scale. A steering committee (four neurologists and two psychiatrists) provided revisions until consensus was reached. The resulting instrument assesses frequency of abnormal movements of the eye/eyelid/face, tongue/mouth, jaw, limb/trunk, complex movements (e.g., handwringing, self-caressing), and vocalizations. The CTI rates symptoms from 0–3 with 0 = absent, 1 = infrequent/intermittent or only present with activating maneuvers, 2 = frequent intermittent, brief periods without movements, 3 = constant or nearly constant. Functional impairments including activities of daily living (ADL), social impairment, symptom bother, and harm are rated 0–3 with 0 = patient is unaware or unaffected, 1 = symptoms mildly impact patient, 2 = symptoms moderately impact patient, 3 = symptoms severely impact patient. Following institutional review board approval, the CTI underwent inter-rater and test-retest reliability testing. Videos of patient TD examinations were obtained and reviewed by two movement disorder specialists to confirm the diagnosis of TD by consensus and the adequacy to demonstrate a TD-consistent movement. Vignettes were created to include patients’ symptom descriptions and functional, social, or occupational impairments/limitations. Four clinicians rated each video/vignette. Selected videos/vignettes were also subject to an intra-rater retest. Interrater agreement was analyzed via 2-way random-effects interclass correlation (ICC) and test-retest agreement assessment utilizing Kendall’s tau-b.
Results
45 video/vignettes were assessed for interrater reliability, and 16 for test-retest reliability. ICCs for movement frequency were as follows: abnormal eye movement .89; abnormal tongue/mouth movement .91; abnormal jaw movement .89; abnormal limb movement .76; complex movement .87; abnormal vocalization .77; and functional impairments including harm .82; social embarrassment .88; ADLs .83; and symptom bother .92. Retests were conducted on mean (SD) 15 (3) days later with scores ranging from .66–.87.
Conclusions
The CTI is a new instrument with good reliability in assessing TD symptoms and functional impacts. Future validation study is warranted.
Evidence-based psychotherapies (EBPs) are underused in health care settings. Aligning implementation of EBPs with the needs of health care leaders (i.e., operational stakeholders) can potentially accelerate their uptake into routine practice. Operational stakeholders (such as hospital leaders, clinical directors, and national program officers) can influence development and oversight of clinical programs as well as policy directives at local, regional, and national levels. Thus, engaging these stakeholders during the implementation and dissemination of EBPs is critical when targeting wider use in health care settings. This article describes how research–operations partnerships were leveraged to increase implementation of an empirically supported psychotherapy – brief Cognitive Behavioral Therapy (brief CBT) – in Veterans Health Administration (VA) primary care settings. The partnered implementation and dissemination efforts were informed by the empirically derived World Health Organization’s ExpandNet framework. A steering committee was formed and included several VA operational stakeholders who helped align the brief CBT program with the implementation needs of VA primary care settings. During the first 18 months of the project, partnerships facilitated rapid implementation of brief CBT at eight VA facilities, including training of 12 providers who saw 120 patients, in addition to expanded program elements to better support sustainability (e.g., train-the-trainer procedures).
Behavioural activation (BA) is an efficacious treatment approach. Activity monitoring is a key component of brief BA treatments; however, no studies have examined the most efficacious format for monitoring. The present pilot study tested brief versus intensive activity monitoring approaches during a BA intervention administered in a college orientation course. Outcomes characterised (1) engagement with the treatment protocol via activity monitoring and (2) participant qualitative experiences with monitoring and the intervention as reported during focus group interviews. Four course sections were randomly assigned to receive monitoring forms that were brief (assessed activities three times daily) or intensive (assessed activities hourly). Forms were provided electronically to students via a web-based platform which tracked completion. There were no significant differences in monitoring frequency (38.0 vs. 23.0 days; p = .154) or the duration of monitoring engagement (62.0 vs. 36.0 days; p = .054) between the brief and intensive conditions. Qualitative findings suggested that participants in both conditions found utility in activity monitoring, particularly during the first month as they transitioned to college. Overall, findings indicated that participants may find utility in monitoring during the first month of a BA intervention using either brief or intensive monitoring forms.
Coronavirus disease 2019 (COVID-19) vaccination rates of a large health system reflected their respective service areas but varied by work role. Nurse vaccination rates were higher (56.9%) and rates among nursing support personnel were lower (38.6%) than those of their communities (51.7%; P < .001). Physician vaccination rates were highest (71.6%) and were not associated with community vaccination levels.
Here, we consider the last decades of ceramic manufacture among the Pawnee in the Central Great Plains, using petrographic analysis to explore raw material availability and use at the Kitkahahki Town site (14RP1). Historical documents reveal tremendous regional pressures and conflicts in the Kitkahahki Town area during its occupation in the late eighteenth and early nineteenth centuries—processes that could have altered or restricted the movement of women outside village boundaries. Contact-era Pawnee pottery from Kitkahahki Town exhibits atypical paste textures, atypical inclusions, or both. At least one potter used atypical materials available immediately adjacent to the village, which suggests that ceramic raw material collection was at least occasionally adjusted to reduce risk. Petrographic analysis contributes to our understanding of Indigenous communities in colonial settings, particularly to questions of technological change and landscape use when both were intensely negotiated and rapidly changing.
HIV-associated neurocognitive disorders (HANDs) are prevalent in older people living with HIV (PLWH) worldwide. HAND prevalence and incidence studies of the newly emergent population of combination antiretroviral therapy (cART)-treated older PLWH in sub-Saharan Africa are currently lacking. We aimed to estimate HAND prevalence and incidence using robust measures in stable, cART-treated older adults under long-term follow-up in Tanzania and report cognitive comorbidities.
Design:
Longitudinal study
Participants:
A systematic sample of consenting HIV-positive adults aged ≥50 years attending routine clinical care at an HIV Care and Treatment Centre during March–May 2016 and followed up March–May 2017.
Measurements:
HAND by consensus panel Frascati criteria based on detailed locally normed low-literacy neuropsychological battery, structured neuropsychiatric clinical assessment, and collateral history. Demographic and etiological factors by self-report and clinical records.
Results:
In this cohort (n = 253, 72.3% female, median age 57), HAND prevalence was 47.0% (95% CI 40.9–53.2, n = 119) despite well-managed HIV disease (Mn CD4 516 (98-1719), 95.5% on cART). Of these, 64 (25.3%) were asymptomatic neurocognitive impairment, 46 (18.2%) mild neurocognitive disorder, and 9 (3.6%) HIV-associated dementia. One-year incidence was high (37.2%, 95% CI 25.9 to 51.8), but some reversibility (17.6%, 95% CI 10.0–28.6 n = 16) was observed.
Conclusions:
HAND appear highly prevalent in older PLWH in this setting, where demographic profile differs markedly to high-income cohorts, and comorbidities are frequent. Incidence and reversibility also appear high. Future studies should focus on etiologies and potentially reversible factors in this setting.
Individual variability in tonic (resting) and phasic (reactivity) respiratory sinus arrhythmia (RSA) may underlie risk for dysregulated emotion and behavior, two transdiagnostic indicators that permeate most psychological disorders in youth. The interaction between tonic and phasic RSA may specify unique physiological profiles during the transition to adolescence. The current study utilized clinically referred youth (Mage = 12.03; s.d. = 0.92) to examine baseline RSA, RSA reactivity, and their interaction as predictors of dysregulated emotion and behavior in daily life.
Method
Participants were 162 youth (47% female; 60% minority) in psychiatric treatment for any mood or behavior problem. RSA was assessed during three, 2-minute baselines and an 8-minute parent-child conflict discussion task. Dysregulated emotion and behavior were assessed during a 4-day ecological momentary assessment protocol that included 10 time-based prompts over a long weekend.
Results
Greater RSA withdrawal to the conflict was associated with dysregulated basic emotion (sadness, anger, nervousness, stress) in daily life. Two distinct interactions also emerged, such that baseline RSA was related to dysregulated complex emotion (shame, guilt, loneliness, emptiness) and dysregulated behavior as a function of RSA reactivity to conflict. Lower baseline RSA and greater RSA withdrawal were associated with dysregulated complex emotion, while higher baseline RSA and greater RSA withdrawal were associated with dysregulated behavior.
Conclusions
Findings point to physiological profiles that increase the risk of dysregulated emotion and behavior during the transition to adolescence. Excessive RSA withdrawal uniquely, and in combination with baseline RSA, increased risk for dysregulation in daily life, underscoring the role of autonomic stress responding as a risk factor for psychopathology.
The present study aims at measuring the association between household food insecurity and psychological distress in adolescents in Inuit communities, concurrently and overtime from childhood to adolescence.
Design:
The study used measures of internalising behaviours (anxiety, withdrawn attitude, somatic complaints and depression) as indicators of psychological distress during adolescence, a concurrent measure of household food insecurity in adolescence and an assessment of longitudinal patterns of household food insecurity from childhood to adolescence. We collected descriptive information at birth, childhood and adolescence on potential confounders.
Setting:
Inuit communities of Nunavik in northern Quebec, Canada
Participants:
The study consisted of 212 participants from the Nunavik Child Development Study, who have been assessed at birth, childhood (mean age = 11 years, range = 9–13 years) and adolescence (mean age = 18 years, range = 16–21 years).
Results:
Concurrent severe household food insecurity in adolescence was associated with higher measures of psychological distress: depression (βstd = 0·26, P < 0·01) and withdrawn attitude (βstd = 0·20, P = 0·04). Persistent household food insecurity (both at childhood and adolescence) was associated with higher levels of adolescent depression (βstd = 0·18, P = 0·02) and anxiety (βstd = 0·17, P = 0·03).
Conclusions:
Adolescents from Nunavik living with higher food insecurity and those having experienced food insecurity in both childhood and adolescence were more likely to report symptoms of psychological distress. Considering the high level of distress experienced by young Inuit, existing initiatives to reduce food insecurity in Nunavik communities should be targeted to include children and adolescents.
Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear.
Methods:
Bipolar CHOICE (N = 482) and LiTMUS (N = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed secondary mixed effects linear regression analyses adjusted for age, gender, smoking and body mass index to investigate relationships between pre-treatment white blood cell (WBC) levels and clinical global impression scale (CGI) response.
Results:
Compared to participants with WBC counts of 4.5–10 × 109/l, participants with WBC < 4.5 or WBC ≥ 10 showed similar improvement within each specific treatment arm and in gender-stratified analyses.
Conclusions:
An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks.
With improvements in early survival following congenital heart surgery, it has become increasingly important to understand longer-term outcomes; however, routine collection of these data is challenging and remains very limited. We describe the development and initial results of a collaborative programme incorporating standardised longitudinal follow-up into usual care at the Children’s Hospital of Philadelphia (CHOP) and University of Michigan (UM).
Methods
We included children undergoing benchmark operations of the Society of Thoracic Surgeons. Considerations regarding personnel, patient/parent engagement, funding, regulatory issues, and annual data collection are described, and initial follow-up rates are reported.
Results
The present analysis included 1737 eligible patients undergoing surgery at CHOP from January 2007 to December 2014 and 887 UM patients from January 2010 to December 2014. Overall, follow-up data, of any type, were obtained from 90.8% of patients at CHOP (median follow-up 4.3 years, 92.2% survival) and 98.3% at UM (median follow-up 2.8 years, 92.7% survival), with similar rates across operations and institutions. Most patients lost to follow-up at CHOP had undergone surgery before 2010. Standardised questionnaires assessing burden of disease/quality of life were completed by 80.2% (CHOP) and 78.4% (UM) via phone follow-up. In subsequent pilot testing of an automated e-mail system, 53.4% of eligible patients completed the follow-up questionnaire through this system.
Conclusions
Standardised follow-up data can be obtained on the majority of children undergoing benchmark operations. Ongoing efforts to support automated electronic systems and integration with registry data may reduce resource needs, facilitate expansion across centres, and support multi-centre efforts to understand and improve long-term outcomes in this population.
The most common strategy recommended for management of jointed goatgrass infestations is to rotate from winter wheat to a spring crop for several years. A field study was conducted at three locations in 1998 and 1999 to determine the effects of spring seeding date on the ability of jointed goatgrass to flower and produce viable seed in the presence or absence of spring wheat and to determine the effect of jointed goatgrass competition and crop seeding date on spring wheat grain yield. Spring wheat was seeded on four dates at each location in both hand-sown and natural jointed goatgrass infestations. Jointed goatgrass plants from hand-sown spikelets flowered and developed spikelets on all seeding dates except the last; viable seed was produced on the two earliest seeding dates. Jointed goatgrass plant densities from natural infestations were from 1 to 12 plants m−2, and spikelet production ranged from 0 to 480 spikelets m−2. Natural jointed goatgrass infestations produced spikelets containing viable seed on all seeding dates at one location in 1998, the driest location. Spring wheat yield was not affected by jointed goatgrass competition; however, jointed goatgrass spikelet production was reduced by spring wheat competition compared with that of monoculture jointed goatgrass. The last seeding date of spring wheat was associated with 51% less crop yield compared with the recommended seeding date. The decision to manage jointed goatgrass infestations with a spring crop rotation should consider delayed seeding dates to minimize viable spikelet production by spring-germinating jointed goatgrass; however, the cost of this decision may include grain yield reduction.
Field studies were conducted to evaluate weed control with combinations of glyphosate at 750 g ae/ha and the insecticides acephate (370 g ai/ha), dicrotophos (370 g ai/ha), dimethoate (220 g ai/ha), fipronil (56 g ai/ha), imidacloprid (53 g ai/ha), lambda-cyhalothrin (37 g ai/ha), oxamyl (280 g ai/ha), or endosulfan (420 g ai/ha) and insect control with coapplication of the herbicide with insecticides acephate, dicrotophos, dimethoate, and imidacloprid. Applying lambda-cyhalothrin or fipronil with glyphosate reduced control of hemp sesbania by 19 and 9 percentage points, respectively, compared with glyphosate alone. Acephate, dicrotophos, dimethoate, imidacloprid, lambda-cyhalothrin, oxamyl, and endosulfan did not affect hemp sesbania, pitted morningglory, prickly sida, and redweed control by glyphosate. Lambda-cyhalothrin and fipronil did not affect glyphosate control of weeds other than hemp sesbania. Addition of glyphosate to dicrotophos improved cotton aphid control 4 d after treatment compared with dicrotophos alone. Thrips control was improved with addition of glyphosate to imidacloprid. Insect control was not reduced by glyphosate regardless of insecticide.
Russian thistle is a severe problem in fields after crop harvest in the Pacific Northwest (PNW) and is controlled either by tillage or broadcast applications of various herbicides. A study was conducted in Washington in 2000 and 2001 at four sites to compare the efficacy of two herbicide treatments applied with a light-activated, sensor-controlled (LASC) sprayer and a conventional broadcast sprayer for postharvest Russian thistle control. Additionally, simple economic comparisons, excluding fixed costs, were made among herbicide treatments and application methods. Both herbicide applicators controlled Russian thistle similarly within each herbicide treatment. Weed control was unacceptable (≤ 75%) when glyphosate plus 2,4-D was applied with either applicator. In contrast, Russian thistle control was > 90% with paraquat plus diuron regardless of applicator. The overall reduction in chemical use was 42% with the LASC compared with the broadcast applicator when averaged over the four sites. Herbicide and surfactant cost savings, using 2007 prices for the LASC compared with the broadcast applicator, ranged from $6.68/ha to $18.21/ha with the paraquat plus diuron treatment and averaged $13.27/ha less for the four sites. The use of the LASC for postharvest Russian thistle control can reduce growers' input costs, increase growers' profits, and improve environmental quality by reducing the amount and area of a restricted-use chemical.
In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.
Ceratodontid lungfishes are generally rare, poorly represented elements of North America’s Mesozoic ecosystems, with previously known maximum diversity in the Late Jurassic. Herein we describe four new species of the form genus Ceratodus, from the Cretaceous of the Western Interior, considerably expanding fossil representation of post-Triassic dipnoans in North America. To model taxonomic and morphologic diversity, we adopt a four-fold system of phenetically based species groups, named for exemplars from the Morrison Formation. Ceratodus kirklandi n. sp. (Potamoceratodus guentheri group) and C. kempae n. sp. (C. frazieri group) represent a hitherto unsampled time interval, the Valanginian. Ceratodus nirumbee n. sp. and C. molossus n. sp. extend the temporal ranges of the C. fossanovum and C. robustus groups upward to the Albian and Cenomanian, respectively. These new occurrences show that ceratodontids maintained their highest diversity from the Late Jurassic through the mid-Cretaceous (Albian–Cenomanian), an interval of ~60 Myr. The existing record suggests that some of the later (mid-Cretaceous) ceratodontids may have been tolerant of salt water; to date, there is no evidence that they aestivated. Only a few occurrences are known from horizons younger than Cenomanian. Demise of ceratodontids appears to be part of a broader pattern of turnover that occurred at the Cenomanian-Turonian boundary in North America.
In patients with first episode Clostridium difficile infection treated with vancomycin or fidaxomicin, more patients receiving fidaxomicin achieved at least 2 log10 colony-forming units/g reduction in spores at the follow-up visit (P=.02). Similar to published literature, a higher proportion of patients receiving fidaxomicin demonstrated sustained clinical response.
Infect. Control Hosp. Epidemiol. 2016;37(2):215–218
IAU Commission 40 for Radio Astronomy (hereafter C40) brought together scientists and engineers who carry out observational and theoretical research in radio astronomy and who develop and operate the ground and space-based radio astronomy facilities and instrumentation. As of June 2015, the Commission had approximately 1,100 members from 49 countries, corresponding to nearly 10 per cent of the total IAU membership.