We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In 3D printing, calibration is crucial for accurate prints, particularly those with complex or intricate features. This paper focuses on developing, manufacturing, and testing a benchmarking model to assess the dimensional accuracy of 3D printers. The aim is to evaluate the 3D printed model against a universally recognized real-world equivalent – a LEGO® brick – using its interlock function as a test with an engaging element. An interlock benchmarking framework aids further analysis of the model's performance, and a checklist for the model is provided for additional visual analysis.
This research communication was designed to evaluate the effects of different levels of diet restriction on the composition and ethanol stability (MES) of raw bovine milk. This research was carried out using three electronic databases: Scopus, Pubmed and Web of Science. The main inclusion criteria were: (i) original research, (ii) use of alcohol (ethanol) test as a method to assess milk stability, (iii) measure different levels of feed restriction and (iv) allow access to the raw data of articles. Of the nine publications that addressed the subject filtered by the systematic review, seven fitted the selection criteria and were selected to perform the meta-analysis. Feed restriction (reduction of 20, 30, 40 and 50% of the dietary dry matter offered) decreased (P < 0.01) milk yield (−18%), ethanol stability (−5%), acidity (−4%), protein (−3%) and lactose (−2%) concentrations, but did not affect the values of pH, density, fat and total solids concentrations, nor somatic cell count. The correlation between milk yield and MES was low but positive and numerically higher in the control group compared with the restriction group. The milk of cows fed the control diet presented greater ethanol stability (76.5%) compared with milk of cows fed the restrictive diet (72.8%). This decrease by up to 4 percentage units due to restriction levels ranging from 20 to 50% of diet intake may cause limitations in milk processing at the dairy industry, increasing milk rejection.
In the aftermath of WWII, Portugal's colonial structure endured several blows, the first pieces collapsing after India's decision to take Goa (1961). Unexpectedly, Portuguese colonial presence ended up outlasting some of its European counterparts. This chapter takes a look at the Portuguese predicament in Asia and discusses the reasons that allowed for the retention of Portuguese sovereignty in Timor until 1974, arguing that such an “anachronism” can only be understood with reference to the political conveniences of Indonesia, as well as to Lisbon's willingness to adjust its policies to the new balance of power in that part of the world. Retaining the façade of colonial sovereignty (essential for the preservation of its “imperial mystique” in Africa and elsewhere), at the cost of adopting a deferential attitude towards Jakarta, was the paramount goal of Lisbon.
Keywords: Portugal, Indonesia, Bandung, European colonialism, decolonisation
The Asian continent was the epicentre of momentous geopolitical changes in the aftermath of the Second World War – the independence of India and Pakistan, Ceylon and Burma, the setting up of the Malayan federation (and the eruption of a guerrilla war lasting from 1948 to 1960), the complete extinction of the “unequal treaties” in China and the victory of the communists there in 1949, as well as the Netherlands’ recognition of Indonesia’s independence in that same year, being some of the milestones of this process.
Significant vestiges of imperial rule (formal and informal) still lingered on well into the mid-1950s, but a decade after the end of hostilities in Europe and the Pacific and the rise of a new world order symbolised by the United Nations Charter, it was evident that the colonial system that had been implemented by the European powers in that part of the world was now seen as unacceptable, with calls for its complete abolition being widely heard across the region.
Indeed, when the Afro-Asian Conference of Bandung was assembled in 1955, a sense of exhilaration concerning the dismissal of the cultural and racial hierarchies brought forth by Western imperialism was perceptible in many of the speeches delivered in the Indonesian city. Afro-Asian leaders in Bandung may have been divided over many issues, but their public rhetoric was fairly homogenous when it came to repudiating racism and colonialism.
Additive manufacturing methods present prospects for designed mechanical deformation via the integration of controlled anisotropic lattice structure forms. Their assimilation into a Design for Additive Manufacturing (DfAM) process would create a novel framework for the design of compliant mechanisms (CM). The method uses lattice structures to replace rigid multi-part mechanisms, with integrated and controlled flexibility into a single, compact, and precise component. In recent years, a lot of research has gone into making algorithms that enable users to generate CMs for their designs. But by relying on algorithms to design solutions, are they neglecting to fully understand how these mechanisms work. This work undertakes the design and development of a novel DfAM Framework, that utilises controlled lattice structure deformations to create a standardised method of CM design. The authors have developed a method for this, whilst allowing users to tailor CMs to their design, by using a wide selection of pretested structures. Indicating suitable structures for their design using an integrated novel taxonomy. The framework is tested and developed using a series of case studies.
Cashew (Anacardium occidentale L.) is cultivated in more than 30 countries because of its economic and nutritional importance. Despite having a significant agronomic role, little is known about the genetic and phenotypic diversity of cashew populations in Brazil. Thus, we aimed to characterize and estimate the diversity among cashew genotypes based on agro-morphological and physicochemical traits, with an objective of selection of varieties for breeding programmes. Forty-three cashew trees were evaluated based on 13 morphological traits and three physicochemical traits. A wide range of variations was recorded for the phenotypic characteristics, including total weight, fruit weight, pseudofruit length, kernel weight and total acidity, suggesting the existence of considerable variations for potential use in breeding programmes. Principal component analysis explained 79.74% of the total variation in the first two principal axes. The dendrogram based on the UPGMA method classified the 43 genotypes into six groups. Groups IV and VI were the most dissimilar, with emphasis on the genotypes 28 and 43, which were observed to be most divergent based on the Euclidean distance matrix (3.054). This makes it possible to select genotypes for hybridization with F1 generation gains. Based on cluster analysis and comparison of means among the six groups, promising genotypes were identified with superior traits, such as fruit weight, pseudofruit length, kernel weight and total acidity. This suggests the importance of phenotypic characterization for cashew breeding programmes. In addition, the observed vast diversity is an important genetic basis for improving cashew yield in northeastern Brazil.
Additive manufacturing offers opportunities for designed mechanical deformation within parts by integrating lattice structures into their designs. This work re-analyses and translates data on lattice structure deformation behaviours into a novel taxonomy, enabling their actions to be understood and controlled. Parallels between these actions and the four basic types of mechanical motion are identified. Creating a taxonomy method using these motions enables the future development of a DfAM framework that assimilates controlled anisotropy via lattices and aids the design of compliant mechanisms.
The inoculation with Azospirillum brasilense has the potential to reduce the use of mineral fertilizers with efficient capacity to promote plant growth and yield. Most studies on the Azospirillum–plant association have been conducted on cereals and annual grasses. More studies are needed in perennial pastures, such as bermudagrass (Cynodon dactylon (L.) Pers.) that require substantial nitrogen (N) fertilization to maximize their production potential. Therefore, pastures based on Tifton 85 bermudagrass in association with annual ryegrass (Lolium multiflorum Lam.), which were inoculated with A. brasilense and fertilized with increasing amounts of N fertilizer and grazed by lactating Holstein cows were evaluated. Three grazing systems were evaluated: (i) Tifton 85, inoculated + 180 kg N/ha per year; (ii) Tifton 85 + 230 kg N/ha per year; and (iii) Tifton 85 + 280 kg N/ha per year. Forage samples were collected before and after grazing to evaluate the responses of the plants and animals. The forage yields of the systems were 21.0, 20.8 and 22.1 t DM/ha per year and the stocking rates were 3.9, 3.8 and 4.0 animal unit/ha per day, respectively. Crude protein, total digestible nutrients and neutral detergent fibre concentrations were 162, 560 and 667 g/kg, respectively. Inoculation in pastures planted with Tifton 85 bermudagrass in combination with ryegrass (plus 180 kg N/ha per year) had a positive effect, providing forage yield and nutritional value equivalent to those with fertilization with 230 kg N/ha per year.
This 29-year-old right-handed woman, diagnosed with schizophrenia at age 21 years, presented with a 3-year history of cognitive decline. Her earliest difficulty was focusing when studying, followed by forgetfulness, both of which affected her performance as a medical student. She ultimately dropped out from school. At the third year of symptoms, her family described her as being disorganized and impulsive. These changes were accompanied by progressive dysarthria and imbalance, with occasional falls.
Two trials were conducted to evaluate the effects of soyabean meal replacement by maize distillers dried grains with solubles (DDGS) in diets for pacu juveniles. Five diets were formulated with 0, 100, 200, 300 and 400 g of DDGS/kg diet replacing up to total dietary soyabean meal. In trial 1, the experimental diets were fed to five groups of fish to evaluate the apparent digestibility coefficients (ADC). In trial 2, four groups of fish were fed each experimental diet for 100 d to evaluate the effects of these diets on digestive enzyme activity, intestine oxidative stress and intestine morphology. The ADC of DM and energy was reduced with dietary DDGS inclusion, while the ADC of lipids was increased, and no differences were observed for the ADC of protein. Independent of dietary treatment, pH increased from anterior to the distal intestine with dietary DDGS inclusion. Digestive enzyme activities were higher on anterior than the distal intestine. Dietary DDGS decreased lipase, amylase, chymotrypsin and trypsin activities, while no differences were observed for total protease activity. Intestine glucose-6-phosphate dehydrogenase was reduced in fish fed the DDGS diets, while catalase activity increased. Lipid peroxidation was lower in fish fed DDGS diets than the control. Intestine histomorphology improved with dietary DDGS inclusion. Overall, the negative effects of soyabean meal could be decreased by dietary replacement with maize DDGS which may have a prebiotic effect, improving intestine health.
The International League Against Epilepsy (ILAE) put forth the definition for intractable epilepsy as the persistence of seizures despite “adequate trials of two tolerated, appropriately chosen and used antiseizure drug [ASD] schedules (whether as monotherapies or in combination).”1 The definition of medically refractory epilepsy has been debated for many years,2 and expert opinion remains divergent from common practice.3 It has been well-documented that the chances of achieving seizure freedom are minimal with additional trials of ASDs and that increased duration of seizures before surgery is associated with decreased chance of long-term seizure freedom.4 The American Association of Neurology 2015 Epilepsy Quality Measures recommend that each patient should have their diagnosis and treatment plan evaluated, and a referral for presurgical evaluation should be considered to a level 4 epilepsy center for those who are medically refractory about once every 2 years.5 As part of this referral and reassessment, surgery should be considered.
Over the last decade, the Antarctic continent has been the object of intensive scientific programmes. However, the emphasis of these studies rarely focuses on the Antarctic as a source of potential elements such as mercury. The release of mercury to the environment is known to occur at Deception Island, associated with volcanic activity. In this study, a 3D hydrodynamic model was used to assess the role of water circulation on the dispersion of released mercury. Sea level variation and tidal circulation data were obtained. Residence time was calculated using two different approaches. Internal tide generation in summer and winter were recognized and the barotropic tidal components obtained. Lagrangian tracers were used to depict particle circulation (simulating particulate mercury) in a three month summer simulation for barotropic and baroclinic conditions. The results show that particles accumulate in the northern and western parts of the bay. It is acknowledged that the results of the 3D model are associated with a non-negligible uncertainty, which can only be reduced with an ongoing commitment to monitoring. The findings of this study indicate that mercury accumulation is occurring in Port Foster (Deception Island), which is a potential threat to the local ecosystem.
The article examines the role played by the Portuguese oppositionist diaspora in the final years of the Estado Novo dictatorship (c. 1968–c.1974). It advances an explanation for the apparent lack of success met by several exile groups when trying to persuade the Western democracies to withdraw (or at least reduce) their support for Lisbon's authoritarian regime during a period in which the public was increasingly aware of human rights abuses. The choice of this particular juncture is justified for several reasons. Firstly, it was a time of renewed expectations regarding a possible liberalisation of the regime in the aftermath of the replacement of the incapacitated Oliveira Salazar by the younger Marcelo Caetano (September 1968), an event that confronted the different sections of the Portuguese opposition with a number of dilemmas, both at home and abroad, and exposed rifts that would take some time to repair. Secondly, this was also an epoch of momentous social and cultural change in Europe, with obvious ramifications for the political orientations and attitudes of those who, for different reasons, had decided to leave Portugal in the 1960s. Finally, the vicissitudes of the East–West détente are seen here as equally important for understanding the opportunities and limitations of the anti-Estado Novo opposition abroad.
Effective control of gastrointestinal parasites is necessary in sheep production. The development of anthelmintics resistance is causing the available chemically based anthelmintics to become less effective. Biological control strategies present an alternative to this problem. In the current study, we tested the larvicidal effects of Bacillus thuringiensis var. israelensis Cry11Aa toxin against Haemonchus contortus larvae. Bacterial suspensions [2 × 108 colony-forming units (CFU) g−1 of the feces] of B. thuringiensis var. israelensis and recombinant Escherichia coli expressing Cry11Aa toxin were added to naturally H. contortus egg-contaminated feces. The larvae were quantified, and significant reductions of 62 and 81% (P < 0·001) were, respectively observed, compared with the control group. A 30 mL bacterial suspension (1 × 108 CFU mL−1) of B. thuringiensis var. israelensis and recombinant E. coli expressing Cry11Aa toxin were then orally administered to lambs naturally infected with H. contortus. Twelve hours after administration, feces were collected and submitted to coprocultures. Significant larvae reductions (P < 0·001) of 79 and 90% were observed respectively compared with the control group. The results suggest that the Cry11Aa toxin of B. thuringiensis var. israelensis is a promising new class of biological anthelmintics for treating sheep against H. contortus.
The long-term effects on growth performance, body composition, plasma metabolites, liver and intestine glucose and lipid metabolism were assessed in gilthead sea bream juveniles fed diets without carbohydrates (CH–) or carbohydrate-enriched (20 % gelatinised starch, CH+) combined with two lipid sources (fish oil; or vegetable oil (VO)). No differences in growth performance among treatments were observed. Carbohydrate intake was associated with increased hepatic transcripts of glucokinase but not of 6-phosphofructokinase. Expression of phosphoenolpyruvate carboxykinase was down-regulated by carbohydrate intake, whereas, unexpectedly, glucose 6-phosphatase was up-regulated. Lipogenic enzyme activities (glucose-6-phosphate dehydrogenase, malic enzyme, fatty acid synthase) and ∆6 fatty acyl desaturase (FADS2) transcripts were increased in liver of fish fed CH+ diets, supporting an enhanced potential for lipogenesis and long-chain PUFA (LC-PUFA) biosynthesis. Despite the lower hepatic cholesterol content in CH+ groups, no influence on the expression of genes related to cholesterol efflux (ATP-binding cassette G5) and biosynthesis (lanosterol 14 α-demethylase, cytochrome P450 51 cytochrome P450 51 (CYP51A1); 7-dehydrocholesterol reductase) was recorded at the hepatic level. At the intestinal level, however, induction of CYP51A1 transcripts by carbohydrate intake was recorded. Dietary VO led to decreased plasma phospholipid and cholesterol concentrations but not on the transcripts of proteins involved in phospholipid biosynthesis (glycerol-3-phosphate acyltransferase) and cholesterol metabolism at intestinal and hepatic levels. Hepatic and muscular fatty acid profiles reflected that of diets, despite the up-regulation of FADS2 transcripts. Overall, this study demonstrated that dietary carbohydrates mainly affected carbohydrate metabolism, lipogenesis and LC-PUFA biosynthesis, whereas effects of dietary lipid source were mostly related with tissue fatty acid composition, plasma phospholipid and cholesterol concentrations, and LC-PUFA biosynthesis regulation. Interactions between dietary macronutrients induced modifications in tissue lipid and glycogen content.