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Aims: Feedback was collected from students at Black Country Healthcare Foundation Trust to survey their satisfaction with their psychiatry placement which has been changed from nine weeks to five and had moved away from a carousel system to allow independent learning for students. Primary aim was to assess student satisfaction with secondary aims to improve access to a broader knowledge of sub-specialities.
Methods: Resident doctors collaborated with the medical student tutor and an initial feedback from students was gained. A plan was formulated to deliver a trust-specific 3-week teaching programme. We created a new improved handbook with opportunities for students to attend sub-specialities.
Suggestions for improvement were collated from each set of new medical students and some from previous years with this updated at the end of each rotation. We also had regular meetings with stakeholders to monitor progress and appointed medical student champions as a way of linking up with each new cohort more easily.
Feedback was collated at the end of each placement and was acted on in real time prior to the next cohort of students starting. There were 5 cohorts of students that were asked to provide feedback across 10 qualitative and quantitative questions within Microsoft Forms.
Results: Initial results showed 64% of students were dissatisfied with the induction process in the first rotation. 45% of people were unhappy with the bedside teaching. Organisation of the sub-specialities was not consistent across the trust. Both positives and negatives were highlighted and tracked. Trends of responses were monitored compared against both time and site (as students were placed across three sites) and acted upon to create an atmosphere of constant improvement and was correlated against informal conversations. After changes were made students were 50% more satisfied with the placement and standard of bedside teaching.
Conclusion: We acted on general themes from the feedback. We concluded that introducing an induction programme to explain placements and reiterate safety would improve the programme. There was increased time on the wards, direct patient contact and sub-speciality experiences. Feedback following changes showed improvement. Improvements in student-focused teaching were seen with better knowledge gained from small group teaching and 3 structured sessions included throughout. Core trainees will continue to reassess on a 5 weekly basis and make changes to the programme accordingly.
This review summarizes findings from studies in companion animals with chronic diseases receiving omega-3 supplementation. Investigated conditions included dermatopathies (dogs n=7), osteoarthritis (dogs n=7, cats n=2), cardiovascular diseases (dogs n=7), dyslipidaemias (dogs n=1), gastroenteropathies (dogs n=2), chronic kidney disease (dogs n=2, cats n=3), cognitive impairment (dogs n=4, cats n=1), and behavioural disorders (dogs n=3). When possible, dosages were standardized to mg/kg using available data on food intake and EPA/DHA concentrations. The minimum and maximum ranges of EPA and DHA, along with their ratios, were as follows: for dermatology 0.99–43 mg/kg EPA and 0.66–30 mg/kg DHA (ratio 1.4–3.4); for osteoarthritis 48–100 mg/kg EPA and 20–32 mg/kg DHA (ratio 1.5–3.4); cardiology 27–54.2 mg/kg EPA and 18–40.6 mg/kg DHA (ratio 1.3–1.5); dyslipidaemia 58.8 mg/kg EPA and 45.4 mg/kg DHA (ratio 1.3); cognition (1/5 studies) 225 mg/kg EPA and 90 mg/kg DHA (ratio 2.5); behaviour (1/3) 31 mg/kg EPA and 45 mg/kg DHA (ratio 0.7). Nephrology and oncology studies lacked sufficient data for calculation. Gastrointestinal diseases do not appear to benefit from omega-3 supplementation, likely due to inflammation-related malabsorption, although few adverse effects were reported in dogs. Other enteropathy studies were low-quality (case reports/series). The lowest omega-6/omega-3 ratio with anti-inflammatory effect was 1:3.75; the highest was 5.5:1. In conclusion, the reviewed EPA and DHA doses appear effective for atopic dermatitis, osteoarthritis, cardiac disease, hyperlipidaemia, and cognitive and behavioural disorders. Further research is needed to clarify efficacy in gastrointestinal and oncological conditions.
The Australian SKA Pathfinder (ASKAP) offers powerful new capabilities for studying the polarised and magnetised Universe at radio wavelengths. In this paper, we introduce the Polarisation Sky Survey of the Universe’s Magnetism (POSSUM), a groundbreaking survey with three primary objectives: (1) to create a comprehensive Faraday rotation measure (RM) grid of up to one million compact extragalactic sources across the southern ∼ 50 per cent of the sky (20,630 deg2); (2) to map the intrinsic polarisation and RM properties of a wide range of discrete extragalactic and Galactic objects over the same area; and (3) to contribute interferometric data with excellent surface brightness sensitivity, which can be combined with single-dish data to study the diffuse Galactic interstellar medium. Observations for the full POSSUM survey commenced in May 2023 and are expected to conclude by mid-2028. POSSUM will achieve an RM grid density of around 30–50 RMs per square degree with a median measurement uncertainty of ∼1 rad m−2. The survey operates primarily over a frequency range of 800–1088 MHz, with an angular resolution of 20″ and a typical RMS sensitivity in Stokes Q or U of 18 μJy beam−1. Additionally, the survey will be supplemented by similar observations covering 1296–1440 MHz over 38 per cent of the sky. POSSUM will enable the discovery and detailed investigation of magnetized phenomena in a wide range of cosmic environments, including the intergalactic medium and cosmic web, galaxy clusters and groups, active galactic nuclei and radio galaxies, the Magellanic System and other nearby galaxies, galaxy halos and the circumgalactic medium, and the magnetic structure of the Milky Way across a very wide range of scales, as well as the interplay between these components. This paper reviews the current science case developed by the POSSUM Collaboration and provides an overview of POSSUM’s observations, data processing, outputs, and its complementarity with other radio and multi-wavelength surveys, including future work with the SKA.
Nidumolu et al’s article in BJPsych Advances illustrates how psychiatrists might use the key concepts of quality improvement (QI) to analyse and improve mental healthcare systems. This commentary on the article points out the importance of recognising the type of problem for which QI is best suited and the role of softer, relational approaches alongside the technical tools of improvement. It also highlights that QI can bring broader benefits to a team and organisation, including improvements in staff engagement and well-being. In mental health services, psychiatrists can play a key role in enabling and role-modelling this approach to problem-solving, as their extensive experience of leading multidisciplinary teams and shared decision-making with patients can be a great asset in QI.
This study aimed to explore combinations of the Brazilian front-of-package nutrition labelling (FoPNL) (high in added sugar, saturated fat and sodium) and/or three specific food additives with cosmetic functions (colourings, flavourings and non-sugar sweeteners - NSS) in packaged foods and beverages marketed in Brazil. This approach intends to strengthen the identification of ultra-processed food products (UPFP) by consumers through the information available on their labels. A cross-sectional study was carried out using data from the list of ingredients and the nutrition facts panel on labels of processed foods and UPFP available in Brazilian supermarkets between April and July 2017, totalling 8,436 food items assessed, of which 84.0% were UPFP. Of the total, 62.7% of the UPFP would have the FoPNL and 65.1%, 37.9% and 12.9% had flavouring, colouring and NSS, respectively. Combining criteria for the FoPNL with any one of the three cosmetic additives analysed, 45.9% of the UPFP were identified, and when considering the presence of the FoPNL, flavouring, colouring or NSS, the identification increased to 89.9%. Results showed that the current FoPNL in Brazil does not facilitate the identification of UPFP. In this sense, labels that indicate the presence of food additives with cosmetic functions (which are UPFP markers) could be a public health strategy to reduce the consumption of UPFP. Currently, food labelling regulations in Brazil are not aligned with Brazilian Dietary Guidelines recommendations.
Toxoplasma gondii non-archetypal strains have distinct virulence profiles and immunological activation in the host when compared with archetypal strains. The present work aims to perform an analysis of the inflammatory profile during acute and early chronic infection by T. gondii atypical strain in an experimental murine model. After euthanasia, blood was collected for the quantification of specific IgG antibodies and their subtypes (IgG1/IgG3) by ELISA; bronchoalveolar lavage (BAL) was realized and immunophenotyping of lymphocytes population was performed at 12- and 30-days post infection (dpi); the levels of IFN-γ, IL-12, IL-10, TNF-α, IL-6, IL-17, nitric oxide and total proteins were determined in the BAL supernatant. Tissue cyst burden was determined in the brain homogenate, and the parasite load in the lungs was assessed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Infection with the CK4 strain induced a lower brain cyst load similar parasite burden in the lungs, and higher levels of IgG1 and IgG3, when compared to ME49. The group infected with the CK4 strain presented higher levels of systemic IFN-γ, and both infected groups displayed similarly elevated levels of systemic TNF-α, IL-6 and IL-17 at 30 dpi, as well as higher numbers of CD4+ and CD8+ T lymphocytes in the acute stage of infection, followed by higher numbers of central and effector CD4+ T cells. IFN-γ levels in the BAL fluid were significantly higher in animals infected with the CK4 strain in both the acute and early chronic stage of infection, highlighting the involvement of the lung environment.
Fluridone was registered for use in rice production in 2023, offering a new herbicide site of action for growers. However, little information is available on the degree of rice tolerance to this herbicide. Field experiments conducted in 2022 and replicated in 2023 near Colt, AR, evaluated the tolerance of 12 rice cultivars to fluridone, applied preemergence or at the 3-leaf growth stage, in separate experiments. Each experiment consisted of one cultivar. Fluridone rates included 0, 168 (1 × label rate), and 336 (2 × label rate) g ai ha−1 in all experiments. Visible injury varied between years in all experiments, likely due to different environmental conditions. In 2022, injury following preemergence applications of fluridone was below 25% across cultivars. In contrast, in 2023, injury ≥30% occurred to five cultivars, with a maximum of 58% observed for the cultivar ‘DG263L’. In both years, only three cultivars exhibited injury ≥20% following fluridone applications at the 3-leaf stage. Fluridone negatively affected shoot density, groundcover, chlorophyll content, and days to 50% heading in most cultivars when applied preemergence. When fluridone was applied to 3-leaf rice, at least one of the variables evaluated was negatively affected in two and nine cultivars in 2022 and 2023, respectively. Grain yield reductions of at least 18% were observed from eight cultivars in 2022, and a grain yield decrease from 9% to 49% from eight cultivars occurred in 2023 in the preemergence experiments. Fluridone applied to rice at the 3-leaf stage did not cause a yield penalty to any cultivar in 2022, whereas in 2023, a yield loss occurred from eight cultivars. Yield loss from the DG263L cultivar occurred at the 1 × rate in both experiments, indicating that this cultivar appears to be sensitive to fluridone, regardless of the application timing. Based on these findings, fluridone tolerance is cultivar-dependent. Furthermore, preemergence applications of fluridone to rice should be avoided.
A new species of Tereancistrum Kritsky, Thatcher & Kayton, 1980, collected from the gills of Brycon nattereri (Bryconidae) in the Cerrado, in the state of Goiás, Brazil, is described based on morphological and molecular data, based on the mitochondrial cytochrome c oxidase subunit 1 (COI) gene region. Tereancistrum campanum n. sp. is distinguished from all its congeners by the unique ‘bell-shaped’ accessory piece in the male copulatory complex. Molecular analysis revealed that the specimens analyzed formed a distinct group from other Tereancistrum sequences and that the sequences of Tereancistrum kerri showed genetic divergence when compared to T. campanum n. sp., confirming the molecular distinction between the two species. This study also expands the knowledge of parasitic diversity in the Tocantins-Araguaia River Basin and extends the geographical distribution of the genus Tereancistrum. The combination of morphological and genetic data was essential for delimiting this new species, highlighting the importance of integrative approaches in understanding the diversity of monogeneans in freshwater fish in Brazil.
Understanding the population structure and genetic diversity of green turtles is crucial for effective conservation. This study investigated the occurrence, genetic composition, and potential origins of green turtles (Chelonia mydas) in the Potiguar Basin, northeastern Brazil, based on stranding data from 2010 to 2019. Analysis revealed that 87.36% of the population consisted of juveniles, primarily females with a curved carapace length (CCL) between 30 and 59.9 cm. Genetic analysis of the mtDNA control region (481 bp, n = 39) revealed eight haplotypes, with CM-A8 (48.7%) and CM-A5 (30.8%) being the most common. This may be related to the geographic position of the Potiguar Basin, located in the ‘corner’ of the South American continent. High haplotype diversity and low nucleotide diversity were observed, consistent with other Brazilian foraging grounds. Mixed stock analysis identified Ascension Island as the primary source population, followed by Guinea-Bissau and Surinam. The results highlight the importance of the Potiguar Basin as a foraging area for green turtles and emphasize the need for comprehensive conservation strategies to protect this vulnerable population.
We carry out timing and spectral studies of the Be/X-ray binary pulsar GX 304-1 using NuStar and XMM-Newton observations. We construct the long-term spin period evolution of the pulsar which changes from a long-term spin-up ($\sim1.3 \times 10^{-13}$ Hz s$^{-1}$) to a long-term spin-down ($\sim-3.4 \times 10^{-14}$ Hz s$^{-1}$) trend during a low luminosity state ($\sim10^{34-35}$ erg s$^{-1}$). A prolonged low luminosity regime ($L_X \sim 10^{34-35}$ erg s$^{-1}$) was detected during 2005–2010 and spanning nearly five years since 2018 December. The XMM-Newton and NuStar spectra can be described with a power law plus blackbody model having an estimated luminosity of $\sim2.5 \times 10^{33}$ and $\sim3.6 \times 10^{33}$ erg s$^{-1}$, respectively. The inferred radius of the blackbody emission is about 100–110 m which suggests a polar-cap origin of this component. From long-term ultraviolet observations of the companion star, an increase in the ultraviolet signatures is detected preceding the X-ray outbursts. The spectral energy distribution of the companion star is constructed which provides a clue of possible UV excess when X-ray outbursts were detected from the neutron star compared to the quiescent phase. We explore plausible mechanisms to explain the long-term spin-down and extended low luminosity manifestation in this pulsar. We find that sustained accretion from a cold disc may explain the prolonged low luminosity state of the pulsar since December 2018 but the pulsar was undergoing normal accretion during the low luminosity period spanning 2005–2010.
Sijilmassi et al. offer a myth-based framework that is particularly useful in understanding the rising tide of Hindu nationalism in contemporary India. We propose that the success of these myths lies partly in drawing upon the evolved human capacity for prestige-based status to induce a sense of belonging and identification with high-prestige Hindu social groups.
How do you create a dance of self-defense? Brazilian choreographers Davi Pontes and Wallace Ferreira try to answer this question by performing with, through, and despite racial objectifi cation. Against the backdrop of Jair Bolsonaro’s election in Brazil, the artists challenge the audience’s gaze by refusing the spectatorial demand that expects mastery and predictability—a demand often linked to racist, sexist, and colonial frameworks.
We present the results of a combined experimental and theoretical investigation of different fluid sheet structures formed during the impingement of a laminar liquid jet on a vial, with a slightly larger diameter than the jet and filled with the same liquid. The present set-up produces all diverse fluid sheet structures, unlike previous experiments that required a deflector disk resulting in no-slip and no-penetration boundary conditions. The water sheet structures are classified into four regimes; regime I: pre-sheet; regime II: puffing, characterized by the periodic formation and destruction of the upward-rising water sheet, an interesting observation not reported earlier; regime III, steady upward, inverted umbrella-like sheet structures; and regime IV, the formation of downward, umbrella-like sheet structures, which can be either open or closed, classically referred to as ‘water bells’. The water sheet structures observed are governed by the non-dimensional parameters: the ratio of vial diameter to the jet diameter at impact ($X$), the capillary number ($Ca$), the Weber number ($We$) and the Froude number ($Fr$). The parametric spaces $X-Ca$, $X-We$ and $X-Fr$ exhibit the demarcation of the four regimes. A semi-empirical expression for the ejection angle of the liquid sheet, primarily responsible for different shapes, is derived in a control volume that provides a theoretical basis for the identified regime diagrams. The puffing water bells in regime II are found to be quasi-steady as the experimental trajectories are in good agreement with the steady-state theory. The rise time of puffing water bells that determines the puffing frequency has been modelled.
Weeds belonging to the Amaranthus family are most problematic for soybean producers. With Palmer amaranth evolving resistance to multiple herbicides labeled for use in soybean, producers seek new sites of action to integrate into season-long herbicide programs. Bayer CropScience plans to launch a Convintro™ brand of herbicides, one being a premixture that will include diflufenican (categorized as a Group 12 herbicide by the Weed Science Society of America [WSSA]), metribuzin (WSSA Group 5), and flufenacet (WSSA Group 15), for use preemergence in soybean. Research trials were conducted in Fayetteville and Keiser, AR, and Holt, MI, in 2022 and 2023, to evaluate the premixture in a season-long program in a dicamba-resistant soybean system. A 0.17:0.35:0.48 ratio of a premixture of diflufenican:metribuzin:flufenacet (DFF-containing premixture) was applied preemergence with different combinations of glyphosate, glufosinate, dicamba, and acetochlor at 28 (early postemergence) and 42 (late postermergence) days after planting (DAP). At the early postemergence timing, the DFF-containing premixture provided >90% control of Palmer amaranth and prickly sida. However, common ragweed, common lambsquarters, morningglory ssp., and annual grass control was ≤80% at this timing. When the late postemergence applications occurred, treatments that had already received an early postemergence application controlled prickly sida, morningglory ssp., Palmer amaranth, and annual grasses to a greater extent than those that had not, indicating the preemergence application of the DFF-containing premixture was not sufficient to provide control of the weed spectrum through 42 DAP. By 70 DAP, all programs provided ≥93% control of all weeds evaluated. Herbicide programs that included the DFF-containing premixture preemergence followed by (fb) EPOST fb LPOST common ragweed, common lambsquarters, morningglory ssp., and annual grasses to a greater than the one-pass postemergence systems. In addition, all herbicide programs evaluated in this study reduced Palmer amaranth seed production by >99%. However, producers who plan to use the DFF-containing premixture may need two postemergence herbicide applications to obtain high levels of weed control throughout the growing season.
Bayer Crop Science anticipates launching several premixtures for use in soybean, targeted at control of Palmer amaranth. One of the premixtures will contain diflufenican (Weed Science Society of America [WSSA] Group 12), metribuzin (WSSA Group 5), and flufenacet (WSSA Group 15) (DFF-containing premixture), offering an alternative site of action for soybean producers. Field experiments were conducted in Arkansas and Michigan to evaluate application timings of the DFF-containing premixture for soybean tolerance and weed control and possible cultivar tolerance differences to diflufenican and the DFF-containing premixture. Soybean injury from the 1X and 2X rates of the DFF-containing premixture ranged from 0% to 60% 14 d after planting (DAP), with injury increasing the closer the herbicide was applied to soybean emergence. Excluding the 2X rate applied 3 DAP in Arkansas in 2023, soybean injury was <20% regardless of location, site-year, application timing, and rate. For weed control experiments, only a 1X rate of the DFF-containing premixture was applied at the various application timings. Control of five weed species, encompassing broadleafs and grasses, ranged from 81% to 98%, regardless of application timing, by 28 DAP. By 42 DAP, weed control ranged from 71% to 97%, with the 14-d preplant application timing typically being the least effective. The DFF-containing premixture and diflufenican alone were applied PRE at 1X and 2X rates for the soybean cultivar study. Soybean metribuzin sensitivity did not affect the degree of crop response, even in a high-pH soil, and injury to soybean never exceeded 20%. Overall, the DFF-containing premixture will be a tool that soybean producers can integrate into a season-long herbicide program for use across the United States regardless of soybean cultivar.
Herbicide-resistant Palmer amaranth is creating additional challenges for producers who choose to adopt a furrow-irrigated rice production system due to the absence of a sustained flood, enabling extended weed emergence. Fluridone has been shown to effectively control Palmer amaranth in cotton production systems and was recently registered for use in rice. Experiments were initiated in 2022 and 2023 1) to evaluate Palmer amaranth control and rice tolerance to preemergence- and postemergence-applied fluridone at 0.5× (84 g ai ha−1) and 1× (168 g ai ha−1) rates on a silt loam soil; and 2) assess the effect of various herbicide programs that contain fluridone on Palmer amaranth biomass, seed production, and rough rice grain yield. Preemergence applications of fluridone at a 1× rate in combination with clomazone resulted in 84% control of Palmer amaranth 21 d after treatment (DAT). Fluridone, in combination with clomazone preemergence, caused up to 36% rice injury 21 DAT; however, early season injury did not negatively affect rice yields. Palmer amaranth biomass and fecundity were reduced with herbicide programs that included fluridone plus florpyrauxifen-benzyl, and, in some instances, there was no Palmer amaranth biomass or seed production following multiple applications of both herbicides. Fluridone- and florpyrauxifen-benzyl–based herbicide programs achieved effective control of Palmer amaranth when applied timely, but injury to hybrid rice is enhanced with preemergence applications of fluridone that are not permitted with the current label.
The Amazon basin has the largest number of fish in the world, and among the most common fishes of the Neotropical region, the threespot (Leporinus friderici) is cited, which in relation to its microparasitic fauna, has described only 1 species of the genus Henneguya, Henneguya friderici. The Myxozoa class is considered an obligate parasite, being morphologically characterized by spores formed by valves connected by a suture line. This study describes a new species of Henneguya sp. in the Amazon region for L. friderici. This parasite was found in the host's pyloric caeca and caudal kidney, with mature spores with a total spore length of 38.4 ± 2.5 (35.9–40.9) μm; the spore body 14.4 ± 1.1 (13.3–15.5) μm and 7.3 ± 0.6 (6.7–7.9) μm wide. Regarding its 2 polar capsules, they had a length of 5.1 ± 0.4 (4.7–5.5) μm and a width of 2.0 ± 0.1 (1.9–2.1) μm in the same pear-shaped, and each polar capsule contained 9–11 turns. Morphological and phylogenetic analyses denote that this is a new species of the genus Henneguya.
Annona crassiflora is a fruit-bearing tree species native to the Cerrado that has ecological and economic potential, mainly due to the production of attractive and useful fruits for a number of species, including humans. To provide a basis for its conservation and breeding, the objective was to assess the diversity and genetic structure of natural populations of the species using inter-simple sequence repeat (ISSR) molecular markers. Eight populations were analysed in the state of Minas Gerais, Brazil, with 24 individuals randomly sampled in each population, reaching a total of 192 trees. Ten ISSR primers were used, resulting in high genetic diversity for the combined data (H* = 0.35 and I* = 0.52). However, a wide range of representative values was observed in the individual assessment of populations, with JAN, GM and MC standing out for their low genetic diversity, resulting in H* of 0.19, 0.23 and 0.24 and I* of 0.28, 0.34 and 0.35, respectively. An analysis of molecular variance showed greater variation within populations, indicating gene flow (Nm), but genetic differentiation between populations was moderate. Bayesian analysis, although resulting in four genetic groups, revealed the presence of a majority group for the GM and JAN populations. We propose measures to maintain these populations, such as raising awareness of local extractivism and planting genetically divergent seedlings. Furthermore, we recommend including of all populations in conservation and breeding programmes, aiming to cover the maximum genetic variation for the species.