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Stock characters named “Nobody” and “Somebody” were mainstays of British performance culture in the mid- to late eighteenth century. Playbills and newspaper advertisements show that these roles were popular with audiences in London, Dublin, and Edinburgh, as well as on the regional stages. Men and women alike took on these personae to deliver songs, prologues, and epilogues, often as part of benefit performances where they chose their most crowd-pleasing roles to maximize ticket sales. Some of the pieces spoken by Nobody and Somebody were popular enough to make their way into print, excerpted in novels and miscellanies. The duo appeared in George Alexander Stevens's wildly popular Lecture on Heads (1764), which traveled across the Atlantic to stages in Charleston, Philadelphia, and New York, continuing to be performed in the early Republic until the nineteenth century. Offstage, the figures were staples of visual culture; as Terry Robinson has shown, audience awareness of these figures from Romantic-era political cartoons formed an important backdrop for Mary Robinson's theatrical afterpiece Nobody (1794).
Bei der Untersuchung von 6 Glaukonitproben mit Hilfe der ‘H-Kernresonanz-Spektroskopie zeigen sich deutlich zwei verschieden gebundene OH-Gruppierungen. Wàhrend die relativ scharfen Signale A auf die in der Oktaederschicht flxierten zwei OH-Gruppen zuriickzufuhren sind, muB fiir die anderen OH-Gruppen des breiteren Signals B eine andere Bindungsnatur gefordert werden. Es ist móglich, dafl es sich bei den OH-Gruppen des Signals B ebenfalls um verschieden gebundene OH-Gruppen handelt und zwar um solche, die an Eisenhydroxid- Verunreinigungen gebunden sind und solche, die zwischenschichtlich in Form von Eisen-Hydroxo-Komplexen gebunden sind. Eine Unterscheidung zwischen letzteren beiden Mòglichkeiten ist aber nicht mòglich.
Health Technology Assessment (HTA) processes have become a fundamental part in the lifecycle of new medicines. However, their deep relation with national legislation creates ambiguous and controversial results between the European countries. Can they be standardized across Europe?
METHODS:
Sources of national differences have been identified in timelines, documents, methods, data interpretation, and conclusions. In order to harmonize and standardize HTA cooperation across Europe the European Network for HTA (EUnetHTA) was established. We analyzed guidelines, requirements, and output of EUnetHTA and noted the differences between those guidelines and the German G-BA (Federal Joint Committee, Gemeinsamer Bundesausschuss) standard and IQWiG (Institute for Quality and Efficiency in Health Care, Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen) methods.
RESULTS:
The comparison between German and European HTAs highlights that although both procedures follow the rules of Evidence-Based Medicine, differences in Body of Evidence, Comparator, Surrogate Endpoints, Subgroups, and Evidence Synthesis may lead to diverging HTA outcomes. The European HTA framework facilitates the appropriate depiction of clinical reality through comprehensive inclusion of the existing evidence with context specific statistical methods. It might become a worldwide platform for HTA evaluation and discussion.
CONCLUSIONS:
Only the involvement of both, pharmaceutical companies and HTA bodies within a unified European framework can lead to a mature and transparent procedure with a reliable outcome independent of legal requirements.
We study the process of clump formation from hydrodynamic instabilities in stellar wind collisions, using analytical and numerical techniques. We show that the cloud G2 in the Galactic Centre could have been formed in this way, with the most promising sources being compact massive binaries, such as IRS 16SW.
We study the evolution of G2 in a Compact Source Scenario, where G2 is the outflow from a low-mass central star moving on the observed orbit. This is done through 3D AMR simulations of the hydrodynamic interaction of G2 with the surrounding hot accretion flow. A comparison with observations is done by means of mock position-velocity (PV) diagrams. We found that a massive (Ṁw = 5× 10−7M⊙ yr−1) and slow (vw = 50 km s−1) outflow can reproduce G2’s properties. A faster outflow (vw = 400 km s−1) might also be able to explain the material that seems to follow G2 on the same orbit.
With the help of 3D AMR hydrodynamical simulations we aim at understanding G2’s nature, recent evolution and fate in the coming years. By exploring the possible parameter space of the diffuse cloud scenario, we find that a starting point within the disc of young stars is favoured by the observations, which may hint at G2 being the result of stellar wind interactions.
We exploit the deep Hα IFU kinematic data from the KMOS3D and SINS/zC-SINF surveys to explore the so far unconstrained outer rotation curves of star-forming disk galaxies at high redshift. Through stacking the signal of ~ 100 massive disks at 0.7 < z < 2.6, we construct a representative rotation curve reaching out to several effective radii. Our stacked rotation curve exhibits a turnover with a steep falloff in the outer regions, significantly strengthening the tantalizing evidence previously hinted at in a handful only of individual disks among the sample with the deepest data.
This finding confirms the high baryon fractions found by comparing the stellar, gas and dynamical masses of high redshift galaxies independently of assumptions on the light-to-mass conversion and Initial stellar Mass Function (IMF). The rapid falloff of the stacked rotation curve is most naturally explained by the effects of pressure gradients, which are significant in the gas-rich, turbulent high-z disks and which would imply a possible pressure-driven truncation of the outer disk.
We have used dedicated 0.7m telescopes in California and Israel to image the halos of ~ 200 galaxies in the Local Volume to 29 mag/sq arcsec, the sample mainly drawn from the 2MASS Large Galaxy Atlas (LGA). We supplement the LGA sample with dwarf galaxies and more distant giant ellipticals. Low surface brightness halos exceeding 50 kpc in diameter are found only in galaxies more luminous than L*, and classic interaction signatures are relatively infrequent. Halo diameter is correlated with total galaxy luminosity. Extended low surface brightness halos are present even in galaxies as faint as MV = - 18. Edge-on galaxies with boxy bulges tend to lack extended spheroidal halos, while those with large classical bulges exhibit extended round halos, supporting the notions that boxy or barlike bulges originate from disks. Most face-on spiral galaxies present features that appear to be irregular extensions of spiral arms, although rare cases show smooth boundaries with no sign of star formation. Although we serendipitously discovered a dwarf galaxy undergoing tidal disruption in the halo of NGC 4449, we found no comparable examples in our general survey. A search for similar examples in the Local Volume identified hcc087, a tidally disrupting dwarf galaxy in the Hercules Cluster, but we do not confirm an anomalously large half-light radius reported for the dwarf VCC 1661.
The stellar radial velocity dispersion profiles of elliptical galaxies can be well described by a power-law σ(r)∝r−β. We analyze a set of elliptical galaxies formed by major mergers of isolated disk galaxies with mass ratios of 1:1 and 3:1 for several orbital configurations (Johansson et al. 2009). The galaxies in our sample show a deviation from the power-law at 1 − 3Reff, which we term the σ-bump (Schauer et al. 2014). This feature is most prominent in remnants of 1:1 mergers and weakens for remnants of mergers with smaller mass ratios, indicating that the σ-bump is a signature of an equal mass merger. The σ-bump does not vanish with time but stays constant once it has formed, in contrast to shells. It can be seen under all projections, making it an observable feature in the outskirts of elliptical galaxies. We indeed identify three possible σ-bump candidates in the sample of 12 SLUGGS-survey ellipticals studied by Pota et al. (2013), who use globular clusters as tracers for the outer stellar halos (see Schauer et al. 2014, for more details). For further comparisons, we here provide for the first time a two dimensional map of the velocity dispersion of one simulated σ-bump galaxy, to identify the σ-bump in observations of kinematic maps out to several Reff. The σ-bump appears as a global ring-like feature if seen face-on and as an extended box-like feature in its edge-on projection.
The outer stellar halos of galaxies contain vital information about the formation history of galaxies, since the relaxation timescales in the outskirts are long enough to keep the memory, while the information about individual formation events in the central parts has long been lost due to mixing, star formation and relaxation. To unveil some of the information encoded in these faint outer halo regions, we study the stellar outskirts of galaxies selected from a fully hydrodynamical high-resolution cosmological simulation, called Magneticum. We find that the density profiles of the outer stellar halos of galaxies over a broad mass range can be well described by an Einasto profile. For a fixed total mass range, the free parameters of the Einasto fits are closely correlated. Galaxies which had more (dry) merger events tend to have lesser curved outer stellar halos, however, we find no indication that the amount of curvature is correlated with galaxy morphology. The Einasto-like shape of the outer stellar halo densities can also explain the observed differences between the Milky Way and Andromeda outer stellar halos.
Given the number of scientific publications on meetings, it seems that the time is ripe for using scientifically based training to develop the skills of meeting leaders. The purpose of this chapter is to outline such a training course developed on the basis of empirical studies, with the target group consisting of participants with managerial responsibility for leading meetings. The suggested two-day training course comprises five modules: Module 1: “Sensitization to and analysis of prevalent meeting culture,” Module 2: “Preparing meetings,” Module 3: “Communication skills for meeting leaders,” Module 4: “Techniques during the meeting,” and Module 5: “Monitoring resolutions and following up on action items.” For each module, we describe the scientific background and outline how this training component can be implemented. We also recommend adding a follow-up event to refresh participants' memory of the training to support its transfer to meeting practice.
The total density profiles of elliptical galaxies can be fit by a single power law, i.e., ρtot ∝ rγ with γ ≈ −2. While strong lensing observations show a tendency for the slopes to become flatter with increasing redshift, simulations indicate an opposite trend. To understand this discrepancy, we study a set of simulated spheroids formed within the cosmological framework. From our simulations we find that the steepness of the total density slope correlates with the compactness of the stellar component within the half-mass radius, and that spheroidal galaxies tend to be more compact at high redshifts than their present-day counterparts. While both these results are in agreement with observations, the observed trend of the total density slope with redshift remains in contradiction to the results from simulations.
In the context of the formation of spiral galaxies the evolution and distribution of the angular momentum of dark matter halos have been discussed for more than 20 years, especially the idea that the specific angular momentum of the halo can be estimated from the specific angular momentum of its disk (e.g. Fall & Efstathiou (1980), Fall (1983) and Mo et al. (1998)). We use a new set of hydrodynamic cosmological simulations called Magneticum Pathfinder which allow us to split the galaxies into spheroidal and disk galaxies via the circularity parameter ϵ, as commonly used (e.g. Scannapieco et al. (2008)). Here, we focus on the dimensionless spin parameter λ = J |E|1/2 / (G M5/2) (Peebles 1969, 1971), which is a measure of the rotation of the total halo and can be fitted by a lognormal distribution, e.g. Mo et al. (1998). The spin parameter allows one to compare the relative angular momentum of halos across different masses and different times. Fig. 1 reveals a dichotomy in the distribution of λ at all redshifts when the galaxies are split into spheroids (dashed) and disk galaxies (dash-dotted). The disk galaxies preferentially live in halos with slightly larger spin parameter compared to spheroidal galaxies. Thus, we see that the λ of the whole halo reflects the morphology of its central galaxy. For more details and a larger study of the angular momentum properties of disk and spheroidal galaxies, see Teklu et al. (in prep.).
We present Magneticum Pathfinder, a new set of hydrodynamical cosmological simulations covering a large range of cosmological scales. Among the important physical processes included in the simulations are the chemical and thermodynamical evolution of the diffuse gas as well as the evolution of stars and black holes and the corresponding feedback channels. In the high resolution boxes aimed at studies of galaxy formation and evolution, populations of both disk and spheroidal galaxies are self-consistently reproduced. These galaxy populations match the observed stellar mass function and show the same trends for disks and spheroids in the mass–size relation as observations from the SDSS. Additionally, we demonstrate that the simulated galaxies successfully reproduce the observed specific angular-momentum–mass relations for the two different morphological types of galaxies. In summary, the Magneticum Pathfinder simulations are a valuable tool for studying the assembly of cosmic and galactic structures in the universe.
In 2011, we discovered a compact gas cloud (“G2”) with roughly three Earth masses that is falling on a near-radial orbit toward the massive black hole in the Galactic center. The orbit is well constrained and pericenter passage is predicted for early 2014. Our data beautifully show that G2 gets tidally sheared apart due to the massive black hole's force. During the next months, we expect that in addition to the tidal effects, hydrodynamics get important, when G2 collides with the hot ambient gas around Sgr A*. Simulations show that ultimately, the cloud's material might fall into the massive black hole. Predictions for the accretion rate and luminosity evolution, however, are very difficult due to the many unknowns. Nevertheless, this might be a unique opportunity in the next years to observe how gas feeds a massive black hole in a galactic nucleus.
We suggest a new formation mechanism for the inclined, sub-parsec scale and counterrotating stellar disks observed around the central black hole in the Milky Way Galactic center. The simulation of a single molecular cloud crashing into a circumnuclear ring of gas leads to the inflow of multiple streams of gas towards the central parsec region. The time delayed arrival of those streams forms multiple, sub-parsec scale accretion disks, with angular momentum depending on the ratio of cloud and circumnuclear ring material. These accretion disks could then be the progenitors which fragmented into the observed stellar disks. A similar event might have also led to the creation of the so-called minispiral in the Galactic center.
Recently the gas and dust cloud “G2” was discovered on a highly eccentric orbit around the massive black hole in the Galactic center. The orbit will bring the cloud as close as 2400 Schwarzschild radii to Sgr A* beginning of 2014. With the help of hydrodynamical simulations using the PLUTO code, we investigate possible origins and the fate of the cloud in the coming years. In this proceedings article, we concentrate on a scenario where G2 is interpreted as a diffuse gas cloud and show its detailed evolution in the observable position-velocity diagrams. We further elaborate on the problem of the tail emission which might or might not be related to the G2 cloud.
The origin of the dense gas cloud “G2” discovered in the Galactic center (Gillessen et al. 2012) is still a debated puzzle. G2 might be a diffuse cloud or the result of an outflow from an invisible star embedded in it. We present here detailed simulations of the evolution of winds on G2's orbit. We find that the hydrodynamic interaction with the hot atmosphere present in the Galactic center and the extreme gravitational field of the supermassive black hole must be taken into account when modeling such a source scenario. We also find that in this scenario most of the Brγ luminosity is expected to come from the highly filamentary densest shocked wind material. G2's observational properties can be used to constrain the properties of the outflow and our best model has a mass outflow rate of Ṁw=8.8 × 10−8 M⊙ yr−1 and a wind velocity of vw = 50 km s−1. These values are compatible with those of a young TTauri star wind, as already suggested by Scoville & Burkert (2013).
We use high-resolution n-body/SPH simulations to study the hydrodynamical interaction between the Large Magellanic Cloud and the hot halo of the Milky Way. We investigate whether the ram-pressure acting on the gaseous disk of the satellite can explain the peculiarities observed in the Hi distribution and the location of the recent star formation activity.