Systemic weight-bias may negatively influence nutrition recommendations and outcomes in the treatment of mental illness(1,2,3). However, weight loss is often considered a primary outcome in mental health care, despite the potential harm that may come from practising within a ‘weight-centric’ paradigm(4). Therefore, it is important to consider the impact of experiences of weight-based discrimination in mental health care, as well as investigate weight-neutral approaches in relation to mental and physical health and wellbeing. This study utilised a sequential explanatory study design. First, a systematic search was performed including observational studies of adult populations, with ≥ 1 mental or physical health outcome, and ≥ 1 validated measure of eating behaviour reflective of a weight-neutral approach. Outcomes were categorised into four domains (mental health, physical health, health promoting behaviours and other eating behaviours). Risk of bias was assessed using the Newcastle-Ottawa Scale. Next, a cross-sectional online survey was conducted among a community sample with self-reported diagnoses of depression or anxiety. Questions collected experiences of weight-stigma in mental health care, and validated measures such as the Depression and Anxiety Stress Scale (DASS-21), Stigmatizing Situations Inventory-Brief (SSI-B), and Weight Bias Internalization Scale (WBIS-M). Quantitative data were statistically analysed using Jamovi, while open-ended responses were thematically analysed using an inductive approach to reach consensus. In the systematic search, 8281 records were identified with 86 studies including 75 unique datasets, and 78 unique exposures including intuitive eating (n = 48), mindful eating (n = 19), and eating competence (n = 11). Eating behaviours were significantly related to lower levels of disordered eating, and depressive symptoms, and greater body image, self-compassion, diet quality, and higher fruit and vegetable intake. Among the 66 survey respondents (mean age 35.5 ± 11y), greater experienced weight bias (SSI-B) was significantly associated with greater depressive symptoms (r = 0.281, p < 0.05), and greater internalised weight-bias (WBIS-M) was significantly associated with greater depressive symptoms (r = 0.492, p < 0.001; β = 0.414, p = 0.001), anxiety symptoms (r = 0.437, p < 0.001; β = 0.390, p = 0.003), stress (r = 0.399, p < 0.01; β = 0.371, p = 0.006) and DASS-21 total score (r = 0.513, p < 0.001; β = 0.453, p < 0.001). Respondents reported experiences of weight-stigma that resulted in the mismanagement of mental health concerns, unsolicited diet and weight loss advice, and healthcare avoidance. Experiences of weight-stigma within mental health care have the potential to negatively impact mental health and nutrition-related recommendations. However, it must be considered that eating behaviours focused on health, not weight, are positively related to a range of mental and physical health outcomes. Therefore, it is vital healthcare professionals understand and assess their own biases related to weight, to reduce the impact of weight-bias on quality of care and consider weight-neutral approaches to better support mental health and wellbeing.

Sedimenting flows occur in a range of society-critical systems, such as circulating fluidised bed reactors and pyroclastic density currents (PDCs), the most hazardous volcanic process. In these systems, mass loading is sufficiently high ($\gg \mathcal {O}(1)$) and momentum coupling between the phases gives rise to mesoscale behaviour, such as formation of coherent structures capable of generating and sustaining turbulence in the carrier phase and directly impacting large-scale quantities of interest, such as settling time. While contemporary work has explored the physical processes underpinning these multiphase phenomena for monodispersed particles, polydispersed behaviour has been largely understudied. Since all real-world flows are polydisperse, understanding the role of polydispersity in gas–solid systems is critical for informing closures that are accurate and robust. This work characterises the sedimentation behaviour of two polydispersed gas–solid flows, with properties of the particles sampled from historical PDC ejecta. Highly resolved data at two volume fractions (1 % and 10 %) are collected using an EulerLagrange framework and is compared with monodisperse configurations of particles with diameters equivalent to the arithmetic mean of the polydisperse configurations. From these data, we find that polydispersity has an important impact on cluster formation and structure and that this is most pronounced for dilute flows. At higher volume fraction, the effect of polydispersity is reduced. We also propose a new metric for predicting the degree of clustering, termed ‘surface loading’, and a model for the coefficient of drag that accurately captures the settling velocity observed in the high-fidelity data.

From its beginnings in the 1978 Declaration of Alma-Ata, universal health coverage (UHC) has been constantly evolving, notably so within the last ten years. Although the 2015 Sustainable Development Goals, which identify both UHC and social protection among its targets, represent an important juncture in this evolution, several States are unlikely to meet the 2030 target deadline. This article traces the history of UHC and social (health) protection in global health law, focusing on their development over the past ten years. It concludes by reflecting on what the future of UHC and social (health) protection should look like and what is needed to fully realize their potential to achieve equity and to meaningfully contribute to the betterment of people and planet, highlighting human rights, One Health, legal and financial considerations as key for the future.

Objectives/Goals: The prevalence of type 2 diabetes (T2D) in adolescents is rising, presenting unique challenges for recruitment in clinical research – particularly among adolescents who belong to minoritized race/ethnic backgrounds. The primary aims of our study are to identify and address barriers to recruiting adolescents, particularly around community trust. Methods/Study Population: This study employed a two-phase approach to evaluate recruitment strategies for underrepresented adolescent populations in genomics studies of T2D. After IRB approval, in Phase 1, we utilized the electronic medical record (EMR) system at Children’s of Alabama to prescreen based on inclusion criteria (adolescents aged 12–18 years with T2D). Recruitment efforts were tailored to address barriers unique to underrepresented populations, such as flexibility in scheduling contact times to accommodate family availability. In Phase 2, we are implementing and assessing the effectiveness of a peer recruitment model, wherein adolescents from underrepresented groups are trained to engage peers within their community. Focus groups (6–8 participants per group) will explore facilitators and barriers to recruitment. Results/Anticipated Results: Phase 1 revealed that EMR prescreening effectively identified eligible participants, and direct outreach (phone calls, face-to-face contact during clinical visits) significantly improved recruitment success, especially among underrepresented adolescents. Flexible scheduling and consolidating study appointments enhanced participation, addressing logistical challenges like geographic distance. However, frequent changes in contact information (phone and email information) created barriers. In Phase 2, early focus group results suggest that peer recruitment is promising, with trust and community engagement being key factors. Adolescents recruited by peers were more likely to participate, though logistical hurdles such as transportation and family concerns remain. Discussion/Significance of Impact: Our study demonstrates the value of personalized outreach and prescreening in improving recruitment among adolescents. These strategies can engage communities that include Black, Indigenous, and People of Colored. These findings underscore the need for flexible recruitment strategies to ensure their participation in T2D adolescent research.

In many areas of The Gambia, West Africa, population crowding in a degraded environment has forced close interactions of diurnal primate species with humans. We assessed intestinal parasitic infection prevalence and diversity in 4 diurnal non-human primate (NHP) species, Chlorocebus sabaeus, Erythrocebus patas, Papio papio and Piliocolobus badius across 13 sampling sites. The effect of human activity, determined by the human activity index, and NHP group size on parasite richness was assessed using a generalized linear mixed model (GLMM). The most common protozoa identified were Entamoeba coli (30%) and Iodamoeba buetschlii (25%). The most common helminths were Strongyloides fuelleborni (11%), Oesophagostomum spp. (9%) and Trichuris trichiura (9%). Two of six (6%) Cyclospora spp. infections detected sequenced as Cyclospora cercopitheci (both in C. sabaeus). The more arboreal P. badius trended towards a lower prevalence of intestinal parasites, although this was not statistically significant (χ2 P = 0.105). Human activity or group size did not have any significant effect on parasite richness for P. badius (P = 0.161 and P = 0.603) or P. papio (P = 0.817 and P = 0.607, respectively). There were insufficient observations to fit a GLMM to E. patas or C. sabaeus. Our reports present the richness and diversity of intestinal parasites in 4 diurnal NHPs in The Gambia, West Africa. Despite desertification and habitat loss, our results indicate that the prevalence and diversity of intestinal parasites in Gambian NHPs are seemingly unaffected by human activity. Further investigation with a larger dataset is required to better elucidate these findings.

There has been an increasing number of applications from unaccompanied asylum-seeking children (UASC) in the United Kingdom in recent years. It is well-known that this population is at high-risk of developing mental health disorders, which require early detection and intervention to facilitate successful integration. This paper describes the introduction of mental health screening for unaccompanied asylum-seeking children in a National Health Service (NHS) outpatient clinic in central London. This follows the results of a two-year retrospective analysis of the health needs of the population in our clinic, which identified a high incidence of disturbance to mood and sleep. We describe the selection process for a culturally appropriate and validated screening tool, piloting the Refugee Health Screener (RHS) tool with 20 UASC in clinic, and using preliminary findings to inform a more targeted referral to community Child and Adolescent Mental Health Services (CAMHS). We conclude that implementation of the RHS-13 is feasible for widespread mental health screening for UASC in an NHS setting, and provide suggestions for future research directions within this field.

The stellar age and mass of galaxies have been suggested as the primary determinants for the dynamical state of galaxies, with environment seemingly playing no or only a very minor role. We use a sample of 77 galaxies at intermediate redshift ($z\sim0.3$) in the Middle-Ages Galaxies Properties with Integral field spectroscopy (MAGPI) Survey to study the subtle impact of environment on galaxy dynamics. We use a combination of statistical techniques (simple and partial correlations and principal component analysis) to isolate the contribution of environment on galaxy dynamics, while explicitly accounting for known factors such as stellar age, star formation histories, and stellar masses. We consider these dynamical parameters: high-order kinematics of the line-of-sight velocity distribution (parametrised by the Gauss-Hermite coefficients $h_3$ and $h_4$), kinematic asymmetries $V_{\textrm{asym}}$ derived using kinemetry, and the observational spin parameter proxy $\lambda_{R_e}$. Of these, the mean $h_4$ is the only parameter found to have a significant correlation with environment as parametrised by group dynamical mass. This correlation exists even after accounting for age and stellar mass trends. We also find that satellite and central galaxies exhibit distinct dynamical behaviours, suggesting they are dynamically distinct classes. Finally, we confirm that variations in the spin parameter $\lambda_{R_e}$ are most strongly (anti-)correlated with age as seen in local studies, and show that this dependence is well-established by $z\sim0.3$.

This work presents visual morphological and dynamical classifications for 637 spatially resolved galaxies, most of which are at intermediate redshift (z ∼ 0.3), in the Middle-Ages Galaxy Properties with Integral field spectroscopy (MAGPI) Survey. For each galaxy, we obtain a minimum of 11 independent visual classifications by knowledgeable classifiers. We use an extension of the standard Dawid-Skene Bayesian model introducing classifier-specific confidence parameters and galaxy-specific difficulty parameters to quantify classifier confidence and infer reliable statistical confidence estimates. Selecting sub-samples of 86 bright (r < 20 mag) high-confidence (> 0.98) morphological classifications at redshifts (0.2 ≤ z ≤ 0.4), we confirm the full range of morphological types is represented in MAGPI as intended in the survey design. Similarly, with a sub-sample of 82 bright high-confidence stellar kinematic classifications, we find that the rotating and non-rotating galaxies seen at low redshift are already in place at intermediate redshifts. We do not find evidence that the kinematic morphology-density relation seen at z ∼ 0 is established at z ∼ 0.3. We suggest that galaxies without obvious stellar rotation are dynamically pre-processed sometime before z ∼ 0.3 within lower mass groups before joining denser environments.

In Singh v Commonwealth (‘Singh’), the High Court was presented with the question whether a person born in Australia can be considered an ‘alien’ for the purpose of s 51(xix) of the Constitution (‘naturalization and aliens’). In a 5:2 decision the Court rejected the plaintiff's argument that birth in Australia necessarily accorded her the status of non-alien and thus a constitutional nationality which could not be displaced by legislative reliance on other heads of power. The decision is important, both for its elucidation of Parliament's scope to regulate Australian citizenship — the subject of a series of important cases over the last two decades involving strong dissents and two reversals in approach — and for its consideration of principles of constitutional interpretation.