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Plotinus' Enneads is a work which is central to the history of philosophy in late antiquity. This is the second edition of the first English translation of the complete works of Plotinus in one volume in seventy years, which also includes Porphyry's Life of Plotinus. Led by Lloyd P. Gerson, a team of experts present up-to-date translations which are based on the best available text, the edition minor of Henry and Schwyzer and its corrections. The translations are consistent in their vocabulary, making the volume ideal for the study of Plotinus' philosophical arguments. This second edition includes a number of corrections, as well as additional cross-references to enrich the reader's understanding of Plotinus' sometimes very difficult presentation of his ideas. It will be invaluable for scholars of Plotinus with or without ancient Greek, as well as for students of the Platonic tradition.
Changing the Rules enters into the debate between theoretical analyses of constitutional amendments (considered the most important part of a constitution) and empirical research (which argues that amendment provisions have little or no significance). George Tsebelis demonstrates how strict provisions are a necessary condition for amendments to have low frequency and significance and provides empirical evidence from case studies and over 100 democracies to corroborate this claim. Examining various cultural theories that dispute these findings, Tsebelis explains why their conclusions have weak foundations. He argues that constitutional rigidity is also a necessary condition for judicial independence and provides theoretical argument and empirical evidence. Tsebelis also establishes a negative correlation between the length of a constitution and problematic indicators such as time inconsistency, low GDP/capita, high corruption, inequality, and lack of innovation. This title is also available as Open Access on Cambridge Core.
Long-term care often falls by the wayside in national policy dialogues. As populations age around the world and the prevalence of chronic conditions increases, greater numbers of people will need care and support, putting added pressures on acute-care facilities, communities, and families, among others. This increase in demand for long-term care raises questions about the capacity of governments to provide access to needed care, how these services will be properly resourced and who should receive these benefits. The Care Dividend provides a roadmap for investing in long-term care systems. It argues for increased public investment in high-quality, universally accessible long-term care and explains why these systems benefit everyone: households, health systems, economies, and societies. Bringing together a team of academics and policy experts from around the world, this book explains why and how governments can, and should, take action.This title is also available as Open Access on Cambridge Core.
This book describes the development of our understanding of the strong interactions in particle physics, through its competing ideas and personalities, its false starts, blind alleys, and moments of glory – culminating with the author's discovery of quarks, real particles living in a deeper layer of reality. How were quarks discovered, what did physicists think they were, and what did they turn out to be? These questions are answered through a collection of personal remembrances. The focus is on the reality of quarks, and why that reality made them so difficult to accept. How Feynman and Gell-Mann practiced physics, with their contrasting styles and motivations, presented different obstacles to accepting this reality. And how was the author, as a graduate student, able to imagine their existence, and act on it? Science buffs, students, and experts alike will find much here to pique their interest and learn about quarks along the way.
In Germany, the utility model is a type of intellectual property right that provides protection for novel and useful inventions. It is governed by the German Utility Model Act (“Gebrauchsmustergesetz” – GebrMG) which was enacted in 1891, making it the oldest still-existing utility model system in the world. Utility models grant the right holder exclusive control over the use and commercialisation of an invention for a period of ten years from the date of filing, subject to the payment of annual renewal fees. In a way, the utility model is the “little sister” of a full-fledged patent (also called a “petty patent”), protecting the same type of subject matter (technical inventions) with a more limited scope.
Edited by
James Ip, Great Ormond Street Hospital for Children, London,Grant Stuart, Great Ormond Street Hospital for Children, London,Isabeau Walker, Great Ormond Street Hospital for Children, London,Ian James, Great Ormond Street Hospital for Children, London
Paediatric orthopaedic surgery is wide-ranging in scope and complexity. Many patients have coexisting conditions, including cerebral palsy and neuromuscular diseases. Cerebral palsy presents a wide spectrum of motor dysfunction. Preoperative assessment must be guided by associated comorbidities and particularly evaluate respiratory function and any associated cardiac disease. Patients with muscular dystrophy presenting for major orthopaedic or spinal surgery have a high risk of morbidity and mortality, which must be discussed preoperatively; inhalational agents must be avoided due to the risk of rhabdomyolysis. Patients with conditions including osteogenesis imperfecta and arthrogryposis must be carefully managed and meticulously positioned for surgery. Major orthopaedic and spinal surgery can be accompanied by a significant risk of bleeding. Multimodal analgesic strategies, including the use of local anaesthetic blocks, should be used. Scoliosis may be congenital, acquired or idiopathic. Adolescent children with idiopathic scoliosis are often otherwise fit and healthy. In contrast, patients with acquired neuromuscular scoliosis often have significant comorbidities, particularly poor cardiorespiratory function, epilepsy and poor nutrition. Elective postoperative ventilation is frequently required. Intraoperative neuromonitoring is employed to detect and prevent potential spinal cord injury. Total intravenous anaesthesia is required for robust neuromonitoring of motor pathways, and muscle relaxation must be avoided intraoperatively.
Paroxysmal movement disorders are a heterogeneous group of syndromes that produce recurrent attacks of involuntary movements without loss of consciousness as their common feature. In this chapter a very short historical overview is given before discussing the current classification and diagnostic criteria of the three main types of paroxysmal movement disorders: paroxysmal kinesigenic dyskinesia, paroxysmal non-kinesigenic dyskinesia and paroxysmal exercise–induced dyskinesia. During the past two decades, a rapidly growing number of genes that cause paroxysmal movement disorders have been reported. This also challenges the current classification because many genetic forms of paroxysmal dyskinesia can be caused by mutations of the same gene. Nevertheless, a first clinical description and classification appears to be reasonable and important. The chapter also describes the episodic ataxias, along with their genetic background, as well as the non-genetic causes of paroxysmal movement disorders, which include vascular, structural, infectious, inflammatory and metabolic causes. The last part of the chapter deals with a proposed approach to a patient with paroxysmal dyskinesia in daily practice.
Healthcare provider self-disclosures are common although sometimes controversial. Providers have unique opportunities to self-disclose for the purpose of conveying empathic concern during Dignity Therapy sessions. We examine the topics of empathic self-disclosures (ESDs) during Dignity Therapy sessions.
Methods
We analyzed 203 audio-recorded, transcribed Dignity Therapy sessions from a stepped-wedge, randomized trial of Dignity Therapy led by 14 nurses and chaplains in outpatient palliative care. We extracted 117 ESDs across sessions and applied thematic analysis guided by the constant comparative method to generate ESD topic themes and properties.
Results
Providers disclosed ESDs referring to topics of Relationships and Family, Personal Experiences and Characteristics, Cohort Communalities, Location and Geography, and Values. Though each provider led multiple Dignity Therapy sessions in this dataset, providers rarely disclosed the same information to more than one patient. Some disclosures subtly shifted the patient’s life review. Providers often acknowledged patients that their self-disclosures were not prescribed elements of Dignity Therapy sessions.
Significance of results
Providers engage in ESD across a range of personal topics in a Dignity Therapy context. Some ESD topics overlapped with those considered appropriate in existing health communication literature. Other topics involved complex or underexamined types of disclosures. While self-disclosures appear to be made with empathic intent, providers undermined the impact of some ESDs by portraying them as unprescribed components of the conversation. More research is needed to assess the positive and negative impacts of ESDs during Dignity Therapy and to support augmentation of Dignity Therapy training protocols to account for providers’ ESDs.
The hypothesized cognitive model of negative symptoms, proposed nearly twenty years ago, is the most prevalent psychological framework for conceptualizing negative symptoms in schizophrenia spectrum disorders (SSDs). The aim of this study was to comprehensively validate the model for the first time, specifically by quantifying the relationships between negative symptom severity and all related dysfunctional beliefs.
Methods
A systematic search was conducted using MEDLINE and PsychINFO, supplemented by manual reviews of reference lists and Google Scholar. Eligible studies were peer-reviewed with data on the direct cross-sectional association between negative symptoms and at least one relevant dysfunctional belief in SSD patients. Screening and data extraction were completed by independent reviewers. Random-effects meta-analyses were performed to pool effect size estimates of z-transformed Pearson’s r correlations. Moderators of these relationships, as well as subset analyses for negative symptom domains and measurement instruments, were also assessed.
Results
Significant effects emerged for the relationships between negative symptoms and defeatist performance beliefs (k = 38, n = 2808), r = 0.23 (95% CI, 0.18–0.27), asocial beliefs (k = 8, n = 578), r = 0.21 (95% CI, 0.12–0.28), low expectancies for success (k = 55, n = 5664), r = −0.21 (95% CI, −0.15 – −0.26), low expectancies for pleasure (k = 5, n = 249), r = −0.19 (95% CI, −0.06 – −0.31), and internalized stigma (k = 81, n = 9766), r = 0.17 (95% CI, 0.12–0.22), but not perception of limited resources (k = 10, n = 463), r = 0.08 (95% CI, −0.13 – 0.27).
Conclusions
This meta-analysis provides support for the cognitive model of negative symptoms. The identification of specific dysfunctional beliefs associated with negative symptoms is essential for the development of precision-based cognitive-behavioral interventions.
The prevalence of youth anxiety and depression has increased globally, with limited causal explanations. Long-term physical health conditions (LTCs) affect 20–40% of youth, with rates also rising. LTCs are associated with higher rates of youth depression and anxiety; however, it is uncertain whether observed associations are causal or explained by unmeasured confounding or reverse causation.
Methods
Using data from the Norwegian Mother, Father, and Child Cohort Study (MoBa) and Norwegian National Patient Registry, we investigated phenotypic associations between childhood LTCs, and depression and anxiety diagnoses in youth (<19 years), defined using ICD-10 diagnoses and self-rated measures. We then conducted two-sample Mendelian Randomization (MR) analyses using SNPs associated with childhood LTCs from existing genome-wide association studies (GWAS) as instrumental variables. Outcomes were: (i) diagnoses of major depressive disorder (MDD) and anxiety disorders or elevated symptoms in MoBa, and (ii) youth-onset MDD using summary statistics from a GWAS in iPSYCH2015 cohort.
Results
Having any childhood LTC phenotype was associated with elevated youth MDD (OR = 1.48 [95% CIs 1.19, 1.85], p = 4.2×10−4) and anxiety disorder risk (OR = 1.44 [1.20, 1.73], p = 7.9×10−5). Observational and MR analyses in MoBa were consistent with a causal relationship between migraine and depression (IVW OR = 1.38 [1.19, 1.60], pFDR = 1.8x10−4). MR analyses using iPSYCH2015 did not support a causal link between LTC genetic liabilities and youth-onset depression or in the reverse direction.
Conclusions
Childhood LTCs are associated with depression and anxiety in youth, however, little evidence of causation between LTCs genetic liability and youth depression/anxiety was identified from MR analyses, except for migraine.
Endogenous reward (intrinsic reward at will) is a fiat currency that is occasioned by steps toward any goals which are challenging and/or uncommon enough to prevent its debasement by inflation. A “theory of mental computational processes” should propose what properties let goals grow from appetites for endogenous rewards. Endogenous reward may be the universal selective factor in all modifiable mental processes.
Nearly 100 years ago, economist John Maynard Keynes predicted that, by today, technological advancements would allow the workweek to dwindle to just 15 hours, or 3 hours per day, and that the real problem of humanity would be filling their time with leisure. Although much has changed in the world of work since this prediction, such a drastic change has not taken place. In this article, several industrial-organizational psychology scholars discuss why this is the case. Why do we continue to work as much as we do, and how might that change? More fundamentally, what do these trends, contra Keynes’ prediction, tell us about the nature of work itself? We use this discussion to propose several research directions regarding the nature of work and how it might change in the future. We depict the phenomenon of working hours as multilevel in nature, and we consider both the positive and negative possible implications of working less than we do now.
The viability of small island developing states (SIDS) is threatened by three distinct processes – a backlash against globalisation; rising geopolitical competition between powers; and accelerating climate change – which are pulling at the threads binding the liberal international order together. We suggest that this order has been kinder to SIDS than is often acknowledged because its underpinning norms – sovereign equality, non-interference, and right to development – are inherently permissive and thus provide SIDS with choices rather than imperatives. Their leaders should fight for the continuation and enhancement of that order rather than be seduced by alternatives. We provide a rationale for and examples of policies to achieve this, including reforms to the way ODA is measured, debt restructured, climate finance allocated, and global governance organised. These enhancements represent the most plausible pathway for SIDS in a period of significant global upheaval. This title is also available as Open Access on Cambridge Core.
Recent studies have challenged the assumption that families are invariable sources of support for cancer caregivers, noting that relationships with family members can have both positive and negative effects on caregiver well-being. This study expands upon prior literature to examine the relationship between cancer caregivers’ perceptions of the quality of their family interactions and their symptoms of anxiety.
Methods
We employed secondary analysis of baseline data from a multisite randomized clinical trial of an intervention for cancer caregivers conducted at 3 large academic palliative care clinics. We performed linear regression analyses to analyze the relationship between caregivers’ perceptions of the quality of their family interactions and their symptoms of anxiety; additional models were estimated to further characterize this relationship with the addition of relevant covariates: race, ethnicity, sex, marital/relationship status, relationship to patient, employment status, household income, and perceived social support received from friends and significant others. We also conducted a sub-analysis of data provided by caregivers who were married or partnered to examine the relationship between their perceptions of the quality of their family interactions and their symptoms of anxiety with relationship satisfaction as a covariate.
Results
Among our analytic sample (n = 244), we identified a significant negative relationship between cancer caregivers’ perceptions of the quality of their family interactions and their symptoms of anxiety; this relationship remained statistically significant with the addition of covariates. Relationship satisfaction was not found to be a statistically significant covariate in our sub-analysis of married or partnered caregivers.
Significance of results
Study results provide strong support for the development, testing, and implementation of interventions to improve family interactions as a strategy to reduce caregiver anxiety.
Widening and diversifying trade networks are often cited among the boom and bust of Bronze and Iron Age worlds. The great distances that goods could travel during these periods are exemplified here as the authors describe the spectroscopic identification of Baltic amber beads in an Iron Age cremation grave at Hama in Syria. Yet these beads are not unique in the Near Eastern record; as the authors show, comparable finds and references to amber or amber hues in contemporaneous texts illustrate the high social and economic value of resinous substances—a value based on perceptions of their distant origin.
We prove that a group $\Gamma $ admits a discrete, topological (equivalently, smooth) action on some simply connected 3-manifold if and only if $\Gamma $ has a Cayley complex embeddable—with certain natural restrictions—in one of the following four 3-manifolds: (i) $\mathbb {S}^3$, (ii) $\mathbb {R}^3$, (iii) $\mathbb {S}^2 \times \mathbb R$, and (iv) the complement of a tame Cantor set in $\mathbb {S}^3$. The fact that these are the only simply connected 3-manifolds that allow such actions is a consequence of the Thurston–Perelman geometrization theorem.
Although family factors are considered important for children’s language acquisition, the evidence comes primarily from affluent societies. Thus, this study aimed to examine the relations between family factors (family’s socioeconomic status [SES], home literacy activities, access to print resources, and parental beliefs) and children’s vocabulary knowledge in both urban and rural settings in China. Data from 366 children (urban group: 109, 4.85 years; rural group: 257, 4.89 years) were collected. Results showed that whereas family’s SES significantly predicted access to print resources and children’s vocabulary knowledge in the rural group, parental beliefs directly predicted children’s vocabulary knowledge in the urban group. Multigroup analysis showed that the associations of family’s SES and access to print resources with children’s vocabulary knowledge were stronger in the rural group than in the urban group. Our findings highlight the importance of considering contextual settings when conceptualising the role of family factors in children’s language acquisition.
How does Durkheim's thought relate to colonialism, imperialism, and postcolonial theory? To answer these questions, I first examine his explicit discussions of empire and colonialism, which are more extensive than previously thought. I then explore the implications of his general perspective—particularly his theories of anomie and morality—for discussions of colonialism and empire. I find that Durkheim was very critical of violent forms of colonialism and imperialism and that he firmly rejected the civilizational and racist discourses that underpinned modern European, and French, colonial conquest. He rejected forms of empire that exist “without internal acquiescence from their subjects,” and that engage in “conquest via annexation” and military imperialism. As an alternative he advocated an “international system of states” based on a universal but socially and historically grounded morality. The article examines the ways Durkheim's thinking pushed beyond existing French understandings and criticisms of colonialism. I then examine the afterlives of his ideas in later research on colonialism by French sociologists. The conclusion considers postcolonial critiques of Durkheim and adumbrates a Durkheimian theory of colonialism and empire.