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This systematic review and meta-analysis evaluates the prevalence of disruptive mood dysregulation disorders (DMDD) in community-based and clinical populations.
Methods
PubMed and PsychINFO databases were searched, using terms specific to DMDD, for studies of prevalence and comorbidity rates conducted in youths below 18.
Results
Fourteen studies reporting data from 2013 to 2023 were included. The prevalence of DMDD in the community-based samples was 3.3% (95% confidence interval [CI], 1.4–6.0) and 21.9% (95% CI, 15.5–29.0) in the clinical population. The differences in the identification strategy of DMDD were associated with significant heterogeneity between studies in the community-based samples, with a prevalence of 0.82% (95% CI, 0.11–2.13) when all diagnosis criteria were considered. Anxiety, depressive disorders, and ADHD were the most frequent comorbidity present with DMDD. The association with other neurodevelopmental disorders remained poorly investigated.
Conclusions
Caution is required when interpreting these findings, considering the quality of the reviewed data and the level of unexplained heterogeneity among studies. This review stresses the importance of considering a strict adhesion to DMDD criteria when exploring its clinical correlates.
To develop a web-based food-frequency questionnaire (FFQ) measuring intake of plant-based protein foods (PBP) among older adults from the province of Quebec, Canada.
Design:
The questionnaire was adapted from an existing self-administered FFQ and first underwent expert panel evaluation for face and content validity. Then, three phases of cognitive testing were conducted in French, using the probe and think aloud approaches. Between each phase, the questionnaire was modified based on participants’ feedback to improve the clarity and comprehension of the questions.
Setting:
Quebec City, Quebec, Canada.
Participants:
Twenty adults aged 65 years and older participated. Purposive sampling was used to maximise variation in sociodemographic characteristics, including gender, age, education level and PBP consumption.
Results:
The expert panel found the twenty-eight-item questionnaire to be a comprehensive measure of PBP intake and suggested minor changes to improve its clarity. The cognitive interviews showed that our PBP-FFQ was generally well understood and identified issues requiring modifications to improve comprehension and accuracy.
Discussion:
Our FFQ provides a comprehensive measure of PBP intake, is well understood by older adults in Québec and will support rigorous assessment of PBP intake in this population but requires further validation to confirm its validity and reproducibility.
The paper focuses on the syntax and semantics of the French verbal prefix auto. It is proposed that auto is an intensifier stating that no agent other than the one specified in the clause (agent-focusing), or, in anticausative clauses, no agent (agent-denying), is responsible for the event. Syntactically, auto merges with a verbal projection, and the nature of the constituent to which it attaches determines and constrains the interpretation of the clause. The proposed analysis of auto provides support for generative approaches in which a v head introduces the external argument role, while a grammatical Voice head determines its syntactic realization.
An enduring problem in North American archaeology concerns the nature of the transition between the Clovis and Folsom Paleoindian complexes in the West. Traditional models indicate a temporal hiatus between the two complexes implying that Folsom was a population replacement for Clovis. Alternatively, if Folsom was an innovation that occurred within Clovis populations and subsequently spread, we would expect to see a temporal overlap. Here, we test these hypotheses using high-quality radiocarbon dates and Bayesian statistics to infer the temporal boundaries of the complexes. We show that the Folsom complex initially appears between 12,900 and 12,740 cal BP, whereas Clovis disappears between 12,720 and12,490 cal BP. Therefore, Folsom may have appeared about 200 years before Clovis disappeared, and so the two complexes likely co-occurred in the West for nearly eight generations. This finding suggests that Folsom was a successful adaptive innovation that diffused through the western Clovis population, eventually going to fixation over multiple generations.
Our professional understanding of the archaeological record is informed through academic research interest, the nature (tensions of time/money/location) of cultural resource management, and the ability of archaeologists to fully access diverse forms of data potentially available to them. Knowledge of eastern Colorado is poorly known, given that 40% of the state is publicly owned (federal and state) and most professional work occurs on land administered by federal agencies in western Colorado. Given this research disparity, we argue that professional archaeologists in eastern Colorado would certainly benefit from expanding their research networks to include the efforts of avocational archaeologists. Our article describes how artifact collectors have searched eastern Colorado for the past 100 years; although their methods differ from professional approaches, their cumulative efforts provide a nuanced read of the archaeological record. Differences relate to increased time spent on sites, access to a variety of landforms, and repeated visits over the long term. We present a case study on playa lake archaeology to emphasize these concepts and provide suggestions as to how archaeologists can create better partnerships to unlock potentially novel perspectives of the archaeological record.
Neorthacheta dissimilis Malloch (Diptera: Scathophagidae) is a poorly known scathophagid fly that feeds and develops on iris (Iridaceae). A survey of its occurrence was performed at the Montréal Botanical Garden (Montréal, Québec, Canada) in 2018, 2019, and 2020. Iris species and cultivars from two subgenera, Iris and Limniris, were evaluated for larval infestation. When pooled for subgenera and years, data from 18 Iris classes revealed high levels of infestation per flower stalk, ranging from 34% to 100%. When analysed per bud or flower, levels of infestation remained high, ranging from 19% to 100%, but generally was lower than for flower stalks as the unit of replication. The mean number of N. dissimilis larvae per infested flower or bud was higher for the subgenus Limniris (1.13) than for the subgenus Iris (1.03), with a maximum of four N. dissimilis larvae per flower being observed. These figures are worrying for horticulturalists because the insect is prevalent and causes either abortion or aesthetic damages to iris flowers.
In response to the treatment gap for anxiety and depressive disorders, psychological treatments with innovative modalities and high implementation potential are essential. Internet CBT (iCBT) is a cost/effective approach that could improve access to a low-intensity evidence-based CBT intervention.
Objectives
To assess the feasibility and acceptability of the French adaptation of the physician-prescribed six-lesson This Way Up transdiagnostic iCBT program for mixed anxiety and depressive disorders developed in Australia.
Methods
Feasibility study with pre- post-intervention evaluations, including an embedded qualitative study in Family Medicine Groups (Quebec, Canada). Inclusion criteria comprise a family physician diagnosis of Major Depression, Panic Disorder, Agoraphobia, Social Anxiety Disorder or Generalized Anxiety Disorder. Primary self-reported outcomes: PHQ-9 (depression) and GAD-7 (anxiety); secondary measures include diagnostic-specific scales and health service utilisation.
Results
Family physicians (N=21) from five Family Medicine Groups prescribed iCBT to 45 patients (30 women, 15 men; mean age = 39.7), 31 initiated the program. To date, 20 patients completed 5 or 6 lessons, nine completed between 2 and 4. Intervention and post-treatment assessments are ongoing, results forthcoming. Results of semi-structured interviews with patients (N=15) and family physicians (ongoing) on iCBT acceptability indicate it is beneficial, practical and easy to use. Program adherence requires patient readiness and determination and could be fostered by motivational support from clinicians.
Conclusions
Results support this French iCBT program’s scaling-up potential to contribute to reducing the gap in evidence-based treatments for common mental disorders. Its implementation in primary care could improve the effectiveness, efficiency and equity to a rapidly accessible treatment.
Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect pulmonary cancer). In this study, we measured externalized and internalized stigma, as well as psychological (depressive symptoms and stressful life events) and physiological (basal salivary cortisol levels) markers of stress in 115 spouses and 154 children of parents suffering from major depressive disorder, cancer, or no illness (control group). The results show that spouses and children from families with parental depression present significantly more externalized stigma than spouses and children from families with parental cancer or no illness, although we find no group differences on internalized stigma. The analysis did not show a significant group difference either for spouses or their children on depressive symptomatology, although spouses from the parental depression group reported greater work/family stress. Finally, we found that although for both spouses children the awakening cortisol response was greater on weekdays than on weekend days, salivary cortisol levels did not differ between groups. Bayes factor calculated on the null result for cortisol levels was greater than 100, providing strong evidence for the null hypothesis H0. Altogether, these results suggest an impact of stigma toward mental health disorder on psychological markers of stress but no impact of stigma on physiological markers of stress. We suggest that these results may be due to the characteristics of the families who participated in the present study.
This essay historicizes the formation of Edward Said's critique of imperial culture before the publication of Orientalism (1978) and examines how it framed the decolonial approach that made him world-renowned. Deeply influenced by the writings of Martinique-born psychiatrist and Algerian revolutionary Frantz Fanon, an Arab tradition of anti-orientalism, existentialist thought, and the Palestinian national movement, the New York-based intellectual reconceptualized the idea of decolonization in the late 1960s in a way that shifted contemporary thinking on social relationships between racial difference and empire from the individual and interpersonal to the collective and intercultural. Through his deep historical, epistemological, and phenomenological digs into orientalism's imperial culture and its myriad ways of being, Said made it his antiracist mandate to liberate consciousnesses from Eurocentrism and empower the universalization of decolonization.
This study used a person-centered approach to identify subgroups of adolescents who are at risk for depression and suicidal ideation. Latent class analysis was first applied to 1,290 adolescents from a Canadian cohort study in order to identify latent vulnerability subtypes based on 18 psychosocial vulnerability factors. Logistic regression analyses were conducted to study the associations between class membership and depressive symptoms and suicidal ideation 2 years later. The moderating role of sex in the associations between latent classes and depressive symptoms was explored. Five latent classes were identified: Low Vulnerability (42%), Substance Use Only (13%), Moderate Vulnerability (28%), Conduct Problems (8%) and High Vulnerability (9%). Compared with the Low Vulnerability class, the probabilities of presenting depressive symptoms were higher for the Substance Use Only class, OR = 1.93, 95% CI [1.21, 3.06], the Moderate Vulnerability class, OR = 2.96, 95% CI [2.09, 4.20], the Conduct Problems class, OR = 3.03, 95% CI [1.84, 4.98], and the High Vulnerability class, OR = 5.4, 95% CI [3.42, 8.53]. Furthermore, interaction effects with sex were identified in relation to depressive symptoms only. The probability of presenting suicidal ideation was higher only for the High Vulnerability class, OR = 4.51, 95% CI [2.41, 8.43]. This study highlights the importance of a person-centered perspective that considers both vulnerability subtypes and sex because these associations are complex rather than linear or additive.
Fratricide comprises approximately 2% of all intra-familial homicides. Analyses of national data on fratricide show that adult males are considerably more likely to be offenders and victims or fratricide. A previous study suggested there were two main categories of fratricide: related to alcohol intoxication or associated with mental disorder.
Objectives
Present and discuss the results of an original study comprising 28 cases of fratricide.
Aims
To provide up-to-date scientific knowledge on fratricide.
Method
This is a retrospective study of 28 cases of fratricides, extracted from a sample of over 1000 consecutive cases of coroners’ files of victims of domestic homicide occurring between 1990–2015.
Results
Two victims out of three were males, most of adult age. There were only 2 female offenders in the whole sample. A majority of victims were Caucasians while 21% were aboriginals. Most victims were stabbed to death. The murders usually occurred at the residence of the victim. In total, 39% of offenders suffered from a major mental illness; 21% were acutely intoxicated at the time. In victims, 29% were under the influence of alcohol and 18% of offenders were free from mental problems.
Conclusion
Our data indicates that fratricides are most often impulsive and lack preparation. The most common method was the opportunistic use of a knife, suggestive of impulsive killing, and this is consistent with the rest of the information including the high rate of alcohol use and intoxication at the time. The study confirmed two main categories of fratricide: impulsive killing in the context of alcohol and dispute and killing associated with psychosis.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
In view of the robust link often inferred between autonomous journalism and the strength of a society's democratic institutions, and against the background of current challenges to journalists’ traditional roles as purveyors of timely and independent information, we interviewed 352 Canadian journalists about their social and political roles and the influences on their news choices. Comparison of their responses against an international data set (N = 27,567) suggests that Canadian journalists place greater value on detached monitorial roles and claim relatively greater autonomy from commercial and other influences on their work. Further, in comparing these findings to an influential panel study from 1996 to 2003, we conclude that the Canadian journalists’ “credo,” focused on neutral reporting and oriented more to perceived public interest than to business or audience interests, remains surprisingly intact despite contemporary pressures on news forms and business models. This professed neutrality is mitigated by a desire to promote diversity and tolerance.
The hypothesis that Old French was not a verb-second (V2) language, but rather a Topic-initial language, is evaluated in a corpus of verb initial (V1) and V2 matrix clauses extracted from a corpus of 12th- and 13th-century texts. It is shown that the initial constituent of V2 clauses is not always a Topic; it may be part of the informational Focus, or it could be an element that is neither Topic nor Focus. In addition, in V1 and V2 sentences with subject inversion, the postverbal subject may be an informational Topic, contrary to the hypothesis that subjects must move to the preverbal position to avoid being interpreted as part of the informational Focus. Therefore, from an Information-Structure point of view, Old French is similar to a standard V2 language like German. However, certain differences between 12th- and 13th-century texts could suggest that the use of the left periphery evolved during the period considered.
Ce numéro spécial de la Revue canadienne de linguistique présente un ensemble d’études sur le français médiéval découlant d'un colloque qui a eu lieu à l'UQAM les 3 et 4 octobre 2014 sous le thème « L'utilisation des corpus (annotés) pour comprendre le changement linguistique ». Dans cette introduction, nous mettrons en évidence trois facteurs qui donnent à ce numéro son intérêt et son unité : les thèmes abordés, les approches linguistiques et sociolinguistiques et les modes d'utilisation des corpus.
Angiogenesis is a critical component during wound healing, and the process is sensitive to mechanical stimuli. Current in vitro culture environments used to investigate three-dimensional microvascular growth often lack dimensional stability and the ability to withstand compression. We investigated the ability of decorin (DCN), a proteoglycan known to modulate collagen fibrillogenesis, incorporated into a collagen hydrogel to increase construct dimensional stability while maintaining vascular growth. DCN did not affect microvascular growth parameters, while increasing the compressive modulus of collagen gels and significantly reducing the contraction of 3% collagen gels after 16 days in culture.
Objectives: Cognitive impairment is an important aspect of Parkinson’s disease (PD), but there is considerable heterogeneity in its presentation. This investigation aims to identify and characterize latent cognitive phenotypes in early PD. Methods: Latent class analysis, a data-driven, person-centered, cluster analysis was performed on cognitive data from the Parkinson’s Progressive Markers Initiative baseline visit. This analytic method facilitates identification of naturally occurring endophenotypes. Resulting classes were compared across biomarker, symptom, and demographic data. Results: Six cognitive phenotypes were identified. Three demonstrated consistent performance across indicators, representing poor (“Weak-Overall”), average (“Typical-Overall”), and strong (“Strong-Overall”) cognition. The remaining classes demonstrated unique patterns of cognition, characterized by “Strong-Memory,” “Weak-Visuospatial,” and “Amnestic” profiles. The Amnestic class evidenced greater tremor severity and anosmia, but was unassociated with biomarkers linked with Alzheimer’s disease. The Weak-Overall class was older and reported more non-motor features associated with cognitive decline, including anxiety, depression, autonomic dysfunction, anosmia, and REM sleep behaviors. The Strong-Overall class was younger, more female, and reported less dysautonomia and anosmia. Classes were unrelated to disease duration, functional independence, or available biomarkers. Conclusions: Latent cognitive phenotypes with focal patterns of impairment were observed in recently diagnosed individuals with PD. Cognitive profiles were found to be independent of traditional biomarkers and motoric indices of disease progression. Only globally impaired class was associated with previously reported indicators of cognitive decline, suggesting this group may drive the effects reported in studies using variable-based analysis. Longitudinal and neuroanatomical characterization of classes will yield further insight into the evolution of cognitive change in the disease. (JINS, 2017, 23, 551–563)
Except for the addition of modern material remains, the archaeological record is a finite resource, which means that, at some point in the future, there will be nothing left to find. In this paper, we model trends in archaeological discovery based on the growth of the field and the probability of site discovery. We compare this model to seven diverse datasets of archaeological discovery trends: (1) all sites from the state of Wyoming, USA; (2) high-altitude archaeological sites from the state of Colorado, USA; (3) mostly complete Neandertal crania; (4) monumental sites of the Maya Classic period; (5) proboscidean kill/scavenge sites globally; (6) Upper Paleolithic sites from Europe; and (7) a compilation of shipwreck discoveries. We forecast discovery trends over the current century. We show that, for all datasets, rates of discovery are in decline, and some segments of the record are near depletion.