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Peer-supported self-management at discharge from early intervention in psychosis services (EIPS) has received limited attention. The MyPREPED (My Personal Recovery Plan for Early Discharge) trial will evaluate a co-designed, digital and paper-based, peer-delivered recovery and self-management focused intervention, tailored for young people exiting EIPS.
Aims
This protocol describes a hybrid type 2 effectiveness–implementation trial designed to assess MyPREPED’s impact, feasibility, real-world implementation and cost–utility.
Method
This multi-site, mixed-method, two-arm (1:1), parallel-group, randomised controlled trial (MyPREPED versus treatment as usual) trial will be delivered across eight Australian EIPS that deliver ultra-high risk and/or first-episode psychosis streams, using a hybrid type 2 implementation–effectiveness design. Eligible participants are young people aged 16 years and over within 6 months of planned discharge from EIPS. Peer coaches will deliver up to ten sessions of using a self-management plan (modules: discharge, recovery, well-being, relapse prevention, goal-setting, service navigation). Co-primary outcomes include (a) mental health recovery (Recovery Assessment Scale – Domains and Stages; effectiveness outcome) and (b) feasibility (Feasibility of Implementation Measure; implementation outcome). Secondary outcomes assess broader effectiveness domains (mental health quality of life, clinical and functional outcomes) and other implementation outcomes. A cost–utility analysis will estimate incremental costs and quality-adjusted life-years associated with MyPREPED, alongside a secondary cost-effectiveness analysis. Analyses will follow intention-to-treat principles, using mixed-effects models.
Conclusions
This study will provide the first rigorous test of a co-designed, peer-delivered recovery and self-management focused intervention specifically targeting EIPS discharge.
When thoroughly assessed, the prevalence of attention-deficit hyperactivity disorder (ADHD) in children/adolescents is estimated at 5%. There is no evidence that ADHD is over-diagnosed in the UK. Indeed, available data point to under-diagnosis, even though rigorous updated post-COVID-19 pandemic data are not available. Some cases may be misdiagnosed due to low-quality assessment, poor adherence to national guidance or inappropriate differential diagnosis. Beyond the controversy around over- or under-diagnosis and over-medicalisation of ordinary behaviours or emotions, the main issue is that UK clinical services cannot adequately support individuals with ADHD who need help. There is a risk that the narrative claiming ‘ADHD is over-diagnosed’ could be used to deny people with properly-diagnosed ADHD the care they deserve.
The clinical outcomes associated with using commercial versus open ISDTs (initial specimen diverting techniques) remain unclear. This multicenter study showed that switching from the commercial to open ISDT did not change blood culture contamination rates, length of stay, or days of therapy with antibiotics, but did reduce laboratory-associated costs.
The prevalence, morbidity and mortality of youth substance misuse should mandate public health prioritisation worldwide. Roots in multiple adversity and child mental health problems point to substance misuse as an indicator of the underlying vulnerability of populations, in which case young people in the developed world are not doing so well. Child services should screen and assess all youth for substance use. Investment in the development of new treatments has shown that interventions can be moderately effective, likely to share core characteristics, and given will, training and resources are readily deployable. However, all studies show a substantial subset had not improved following intervention, so that enormous scientific and cultural challenges persist.
An estimated 93,000 persons were potentially exposed to drinking water contaminated with petroleum jet propellant (JP)-5 fuel after a November 20, 2021, leak at the Red Hill Bulk Fuel Storage Facility on Oahu, Hawaii. Previous investigations identified the need to evaluate long-term mental health effects associated with JP-5 exposure.
Methods
We identified adults potentially exposed to jet fuel-contaminated water during November 20, 2021-March 18, 2022, who sought care within the military health system through February 24, 2023. We abstracted a sample of electronic medical records and categorized documented mental health conditions and symptoms as “worsening preexisting” or “persistent new.” We also assessed mental health-related medication use before and after November 20, 2021.
Results
We abstracted medical charts for 411 adults potentially exposed to jet fuel-contaminated water. Of this cohort, 123 (29.9%) had documented worsening preexisting mental health conditions or symptoms, 86 (20.9%) had persistent new mental health conditions or symptoms, and 109 (26.5%) had at least one mental health-related medication prescribed after the exposure event.
Conclusions
These results highlight mental health needs during and after water contamination events. Continued access to mental health care services and monitoring for long-term mental health effects is recommended.
This chapter recommends an approach to teaching art in the early years that begins with an underpinning layer of post-structuralist theory. Post-structuralist theories help to examine and question some heartfelt beliefs about art in the early years. There are a number of different theories for teaching the arts with young children. Mostly, it is the role of the teacher that is the focus for examination and analysis. Educators can use theory about discourse and the construction of ideas, thoughts and practices to challenge taken-for-granted beliefs and consciously decide on ways they can support children’s arts learning and their wellbeing.
Using Northern Ireland as a compelling case study, this book offers a critique of peacebuilding approaches with young people in contested societies. Offering a new model to understand peacebuilding, the authors urge peacebuilding communities around the globe to embrace an increasingly politicising and participative youth peace praxis.
On November 20, 2021, petroleum fuel contaminated the Red Hill well, which provides water to about 93 000 persons on Oahu, Hawaii. Initial investigations recommended further evaluations of long-term health effects of petroleum exposure in drinking water. We reviewed electronic health records of those potentially exposed to contaminated water to understand prevalence of conditions and symptoms.
Methods
A sample of persons potentially exposed during November 20, 2021-March 18, 2022 who sought care within the military health system through February 24, 2023 was identified. Abstracted records were categorized as worsening preexisting or persistent new for conditions and symptoms.
Results
Of 653 medical charts reviewed, 357 (55%) had worsening preexisting or persistent new conditions or symptoms. Most-documented conditions included worsening preexisting migraine (8%; 50/653) and chronic pain (4%; 26/653), and persistent new migraine (2%; 14/653) and adjustment disorder (2%; 13/653). Most-documented symptoms included worsening preexisting headache (8%; 49/653) and anxiety (6%; 42/653), and persistent new rash (7%; 46/653) and headache (5%; 34/653).
Conclusions
Approximately half of the abstracted medical records demonstrated worsening preexisting or persistent new conditions or symptoms and might benefit from sustained access to physical, mental, and specialized health care support systems. Continued monitoring for long-term health outcomes is recommended.
The 1994 discovery of Shor's quantum algorithm for integer factorization—an important practical problem in the area of cryptography—demonstrated quantum computing's potential for real-world impact. Since then, researchers have worked intensively to expand the list of practical problems that quantum algorithms can solve effectively. This book surveys the fruits of this effort, covering proposed quantum algorithms for concrete problems in many application areas, including quantum chemistry, optimization, finance, and machine learning. For each quantum algorithm considered, the book clearly states the problem being solved and the full computational complexity of the procedure, making sure to account for the contribution from all the underlying primitive ingredients. Separately, the book provides a detailed, independent summary of the most common algorithmic primitives. It has a modular, encyclopedic format to facilitate navigation of the material and to provide a quick reference for designers of quantum algorithms and quantum computing researchers.
This chapter covers quantum algorithmic primitives for loading classical data into a quantum algorithm. These primitives are important in many quantum algorithms, and they are especially essential for algorithms for big-data problems in the area of machine learning. We cover quantum random access memory (QRAM), an operation that allows a quantum algorithm to query a classical database in superposition. We carefully detail caveats and nuances that appear for realizing fast large-scale QRAM and what this means for algorithms that rely upon QRAM. We also cover primitives for preparing arbitrary quantum states given a list of the amplitudes stored in a classical database, and for performing a block-encoding of a matrix, given a list of its entries stored in a classical database.
This chapter covers the multiplicative weights update method, a quantum algorithmic primitive for certain continuous optimization problems. This method is a framework for classical algorithms, but it can be made quantum by incorporating the quantum algorithmic primitive of Gibbs sampling and amplitude amplification. The framework can be applied to solve linear programs and related convex problems, or generalized to handle matrix-valued weights and used to solve semidefinite programs.
This chapter covers quantum algorithmic primitives related to linear algebra. We discuss block-encodings, a versatile and abstract access model that features in many quantum algorithms. We explain how block-encodings can be manipulated, for example by taking products or linear combinations. We discuss the techniques of quantum signal processing, qubitization, and quantum singular value transformation, which unify many quantum algorithms into a common framework.
In the Preface, we motivate the book by discussing the history of quantum computing and the development of the field of quantum algorithms over the past several decades. We argue that the present moment calls for adopting an end-to-end lens in how we study quantum algorithms, and we discuss the contents of the book and how to use it.
This chapter covers the quantum adiabatic algorithm, a quantum algorithmic primitive for preparing the ground state of a Hamiltonian. The quantum adiabatic algorithm is a prominent ingredient in quantum algorithms for end-to-end problems in combinatorial optimization and simulation of physical systems. For example, it can be used to prepare the electronic ground state of a molecule, which is used as an input to quantum phase estimation to estimate the ground state energy.
This chapter covers quantum linear system solvers, which are quantum algorithmic primitives for solving a linear system of equations. The linear system problem is encountered in many real-world situations, and quantum linear system solvers are a prominent ingredient in quantum algorithms in the areas of machine learning and continuous optimization. Quantum linear systems solvers do not themselves solve end-to-end problems because their output is a quantum state, which is one of its major caveats.
This chapter presents an introduction to the theory of quantum fault tolerance and quantum error correction, which provide a collection of techniques to deal with imperfect operations and unavoidable noise afflicting the physical hardware, at the expense of moderately increased resource overheads.
This chapter covers the quantum algorithmic primitive called quantum gradient estimation, where the goal is to output an estimate for the gradient of a multivariate function. This primitive features in other primitives, for example, quantum tomography. It also features in several quantum algorithms for end-to-end problems in continuous optimization, finance, and machine learning, among other areas. The size of the speedup it provides depends on how the algorithm can access the function, and how difficult the gradient is to estimate classically.
This chapter covers quantum algorithms for numerically solving differential equations and the areas of application where such capabilities might be useful, such as computational fluid dynamics, semiconductor chip design, and many engineering workflows. We focus mainly on algorithms for linear differential equations (covering both partial and ordinary linear differential equations), but we also mention the additional nuances that arise for nonlinear differential equations. We discuss important caveats related to both the data input and output aspects of an end-to-end differential equation solver, and we place these quantum methods in the context of existing classical methods currently in use for these problems.