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To determine risk factors for the development of long coronavirus disease 2019 (COVID-19) in healthcare personnel (HCP).
Methods:
We conducted a case–control study among HCP who had confirmed symptomatic COVID-19 working in a Brazilian healthcare system between March 1, 2020, and July 15, 2022. Cases were defined as those having long COVID according to the Centers for Disease Control and Prevention definition. Controls were defined as HCP who had documented COVID-19 but did not develop long COVID. Multiple logistic regression was used to assess the association between exposure variables and long COVID during 180 days of follow-up.
Results:
Of 7,051 HCP diagnosed with COVID-19, 1,933 (27.4%) who developed long COVID were compared to 5,118 (72.6%) who did not. The majority of those with long COVID (51.8%) had 3 or more symptoms. Factors associated with the development of long COVID were female sex (OR, 1.21; 95% CI, 1.05–1.39), age (OR, 1.01; 95% CI, 1.00–1.02), and 2 or more SARS-CoV-2 infections (OR, 1.27; 95% CI, 1.07–1.50). Those infected with the SARS-CoV-2 δ (delta) variant (OR, 0.30; 95% CI, 0.17–0.50) or the SARS-CoV-2 o (omicron) variant (OR, 0.49; 95% CI, 0.30–0.78), and those receiving 4 COVID-19 vaccine doses prior to infection (OR, 0.05; 95% CI, 0.01–0.19) were significantly less likely to develop long COVID.
Conclusions:
Long COVID can be prevalent among HCP. Acquiring >1 SARS-CoV-2 infection was a major risk factor for long COVID, while maintenance of immunity via vaccination was highly protective.
The ability to recognize others’ emotions is a central aspect of socioemotional functioning. Emotion recognition impairments are well documented in Alzheimer’s disease and other dementias, but it is less understood whether they are also present in mild cognitive impairment (MCI). Results on facial emotion recognition are mixed, and crucially, it remains unclear whether the potential impairments are specific to faces or extend across sensory modalities,
Method:
In the current study, 32 MCI patients and 33 cognitively intact controls completed a comprehensive neuropsychological assessment and two forced-choice emotion recognition tasks, including visual and auditory stimuli. The emotion recognition tasks required participants to categorize emotions in facial expressions and in nonverbal vocalizations (e.g., laughter, crying) expressing neutrality, anger, disgust, fear, happiness, pleasure, surprise, or sadness.
Results:
MCI patients performed worse than controls for both facial expressions and vocalizations. The effect was large, similar across tasks and individual emotions, and it was not explained by sensory losses or affective symptomatology. Emotion recognition impairments were more pronounced among patients with lower global cognitive performance, but they did not correlate with the ability to perform activities of daily living.
Conclusions:
These findings indicate that MCI is associated with emotion recognition difficulties and that such difficulties extend beyond vision, plausibly reflecting a failure at supramodal levels of emotional processing. This highlights the importance of considering emotion recognition abilities as part of standard neuropsychological testing in MCI, and as a target of interventions aimed at improving social cognition in these patients.
A Salmonella agona strain has caused a hospital outbreak of gastroenteritis in a pediatric unit in Rio de Janeiro. It bears two plasmids, a small (6·5 MDa molecular weight) plasmid coding for type B colicin production and a larger one (36 MDa molecular weight) determining resistance to ampicillin, gentamicin, kanamycin and trimethoprim-sulphamethoxazole. The R-plasmid, but not the Col-plasmid, is self-transferable to a Escherichia coli recipient strain. Curing for the R-plasmid was achieved by treatment with 0·05 % SDS followed by incubation at 44°C. It has not been possible to cure the S. agona strain for its Col-plasmid.
We studied the correlation between the spatial frequency of complex stimuli and neuronal activity in the monkey inferotemporal (IT) cortex while performing a task that required visual recognition. Single-cell activity was recorded from the right IT cortex. The frequency components of the images used as stimuli were analyzed by using a fast Fourier transform, and a modulus was obtained for 40 spatial frequency ranges from 0.3 to 11.1 cycles/deg. We recorded 82 cells showing statistically significant responses (analysis of variance, P < 0.05) to at least one of the images used as a stimulus. Seventy-eight percent of these cells (n = 64) showed significant responses to at least three images, and in two thirds of them (n = 42), we found a statistically significant correlation (P < 0.05) between cell response and the modulus amplitude of at least one frequency range present in the images. Our results suggest that information about spatial frequency of the visual images is present in the IT cortex.
This study provides the first compilation on age and growth of some delphinids in south-eastern Brazil (18°25′S–25°45′S). A total of 154 delphinids were reported: 44 Atlantic spotted dolphin Stenella frontalis; 36 bottlenose dolphin Tursiops truncatus; 26 ‘Brazilian’ common dolphin Delphinus sp.; 20 rough-toothed dolphin Steno bredanensis; 16 Fraser's dolphin Lagenodelphis hosei; 3 false killer whale Pseudorca crassidens; 3 unidentified Stenella sp.; 2 pantropical spotted dolphin Stenella attenuata; 2 short-finned pilot whale Globicephala macrorhynchus; 1 spinner dolphin Stenella longirostris; and 1 striped dolphin Stenella coeruleoalba. Age was estimated by counting the number of growth layer groups present in the dentine in 74.5% of the sample. The growth of 92 individuals of the first five species was determined by the Gompertz model to length-at-age data. Stenella frontalis—the oldest specimen was 23 y and the asymptotic length of 224.4 cm predicted by growth curve occurred at about 20 y; T. truncatus—the oldest specimen was 26 y and the asymptotic length of 301.3 cm predicted by growth curve occurred at about 20 y; Delphinus sp.—the oldest dolphin was 18 y and the asymptotic length of 215.9 cm predicted by growth curve occurred at about 5–6 y; S. bredanensis—the oldest specimen was 24 y and the asymptotic length of 258.1 cm predicted by growth curve occurred at about 10 y; L. hosei—the oldest specimen was 19 y and the asymptotic length of 231.2 cm predicted by growth curve occurred at about 7–8 y. Only age was estimated for the other species. The age-at-length data for S. frontalis, Delphinus sp., S. bredanensis and L. hosei were consistent, suggesting a good agreement with previous work on these species. For T. truncatus, the age at asymptotic length obtained in this study might be confirmed by increasing the sample size. The information currently presented will contribute to further life history research of delphinids on the western south Atlantic coast.
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