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Social anhedonia, indicating reduced pleasure from social interaction, is heightened in autistic youth and associated with increased internalizing symptoms transdiagnostically. The stability of social anhedonia over time and its longitudinal impact on internalizing symptoms in autism have never been examined.
Methods
Participants were 276 autistic children (Mage = 8.60, SDage = 1.65; 211 male) with IQ ≥ 60 (MIQ = 96.74, SDIQ = 18.19). Autism severity was measured using the Autism Diagnostic Observation Schedule, Second Edition. Caregivers completed the Child and Adolescent Symptom Inventory, Fifth Edition (CASI-5) at baseline, 6 weeks, and 6 months. The CASI-5 includes a social anhedonia subscale derived from relevant items across domains. ICC (Intraclass Correlation Coefficient) analysis assessed stability, while cross-lagged panel models examined associations among social anhedonia, depression, and social anxiety across time.
Results
At baseline, social anhedonia correlated with autism severity, as well as parent-reported social anxiety and depression. Social anhedonia showed relative stability (ICC = 0.763) over 6 months, with a significant decline between baseline and 6 weeks (β = −0.52, p < .001). Cross-lagged models revealed a bidirectional relationship between social anhedonia and depression over time, while social anxiety displayed concurrent, but not predictive, associations across time.
Conclusions
Social anhedonia demonstrated stability over 6 months, suggesting that it may be a relatively stable characteristic in autistic children. Concurrent relationships were observed between social anhedonia and depression, as well as social anxiety and attention-deficit/hyperactivity disorder. Only depression demonstrated a bidirectional longitudinal association with social anhedonia. This bidirectional relationship aligns with developmental models linking early negative social experiences to subsequent internalizing symptoms in autistic children, underscoring the clinical significance of social anhedonia assessment in this population.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
This chapter uses a case comparison to show the behavioral consequences of uncertainty about relationality – how it prevents new collaborative relationships that people would value from forming in the first place.
This chapter discusses the importance of collaborative relationships in civic life, and how the relationships that people would value do not always arise on their own. Instead, there can be an unmet desire to collaborate. It underscores why it’s important to distinguish between two types of goals for collaborative relationships: informal collaboration oriented toward knowledge exchange, and formal collaboration oriented toward projects with shared ownership, decision-making authority, and accountability. It also introduces the book’s main argument, which is that in addition to commonly cited factors such as resource constraints and a lack of organizational incentives, unmet desire arises because potential collaborators (who often begin as strangers) can be uncertain how to relate to each other. Uncertainty about relationality is a key barrier to new collaborative relationships. Last, the chapter also connects a rich understanding of the science of collaboration to several other topics: the nature of democratic agency, how to strengthen the link between science and society, the nature of discursive participation as a form of civic engagement, and how we conceptualize civic competence.
This chapter summarizes the main findings of the book, and then presents a tool called an unmet desire survey (designed based on those findings) that potential collaborators and organizational leaders can use in order to form new collaborative relationships. It also briefly discusses how the findings are helpful for forming new research partnerships, a type of formal collaboration discussed in greater detail in one of the appendices. Last, it includes several policy recommendations for how organizational leaders can put the results into practice, as well as science policy recommendations for valuable future research on the unmet desire to collaborate in civic life.
Relationality captures how people want others to relate to them, and how they will relate to diverse others, yet as this chapter shows “relating to others” may include many different elements and be person- and/or context-specific. This chapter uses interviews with nonprofit practitioners and researchers, and also national surveys of policymakers and AmeriCorps program leaders, to lay out some of the ways in which different kinds of people who seek change in civic life express uncertainty about relationality.
This chapter provides an overview of the theory of relationality – the idea that people care about how others relate to them, and whether they can successfully relate to others – and how potential collaborators can be uncertain about these relational aspects. “Relating to others” captures both the information to be shared, and also the experience of interacting. Key to the theory of relationality, as it applies to potential collaborators with diverse forms of expertise, is that status-based stereotypes can drive a wedge between having expertise and having that expertise be socially recognized. This chapter builds up to a series of hypotheses about how potential collaborators care about the information to be shared and the experience of interacting when choosing whether to engage in new collaborative relationships with diverse thinkers. It also identifies several possible interventions for fostering valuable new collaborative relationships.
This chapter tests two ways of overcoming uncertainty about relationality – having potential collaborators directly communicate how they will relate to each other, and using third parties such as matchmakers and boundary spanners. Both are useful for creating valuable new collaborative relationships, especially between people who begin as strangers. In addition, this chapter also presents evidence showing the impact of new collaborative relationships on strategic decision-making. Data in this chapter come from a variety of national surveys, field experiments, and case comparisons.
Those who seek change in civic life have much in common: they each bring valuable expertise to the table and need to strategize with others about what to do. That's why new collaborative relationships between diverse thinkers are essential. Yet they're difficult to form. Collaborate Now! presents a new argument about why that is, along with tools to foster them anew. As with any form of voluntary civic engagement, these relationships require time and motivation. Yet on top of that, collaborators often start off as strangers, and are uncertain about relationality: whether they'll relate to each other in ways that are meaningful and brimming with interaction. Using case studies, field experiments, interviews, and observational data, this book provides a rich understanding of the collaborative relationships needed to tackle civic challenges, how uncertainty about relationality can produce an unmet desire for them, and actionable tools to surface and meet this desire.