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The Berlin Conference (1884–85) is widely studied for its role in fuelling European imperialism and legitimising the scramble for Africa. However, its global impact beyond Europe and Africa has received little attention, with Latin America notably absent. This article examines how prominent diplomats from Argentina, Brazil, Colombia, and Mexico interpreted the proceedings. In their view, Europe’s renewed expansionism in Africa—combining private adventurism, colonisation enterprises, and imperial statecraft—resembled the great powers’ incursions into post-independence Latin America. They feared that new criteria for staking colonial claims would endanger their states’ sovereignty over vast, remote territories. Yet, while opposing intervention, these diplomats embraced civilisational thinking and state-building projects that echoed Eurocentric racial hierarchies. Their arguments reflected both resistance to imperialism and complicity in its logic. By tracing Berlin’s reverberations across multiple regions, this article highlights the broader repercussions of late nineteenth-century ‘high imperialism’ and reassesses the nature of Latin American anti-imperialism.
Employment and relationship are crucial for social integration. However, individuals with major psychiatric disorders often face challenges in these domains.
Aims
We investigated employment and relationship status changes among patients across the affective and psychotic spectrum – in comparison with healthy controls, examining whether diagnostic groups or functional levels influence these transitions.
Method
The sample from the longitudinal multicentric PsyCourse Study comprised 1260 patients with affective and psychotic spectrum disorders and 441 controls (mean age ± s.d., 39.91 ± 12.65 years; 48.9% female). Multistate models (Markov) were used to analyse transitions in employment and relationship status, focusing on transition intensities. Analyses contained multiple multistate models adjusted for age, gender, job or partner, diagnostic group and Global Assessment of Functioning (GAF) in different combinations to analyse the impact of the covariates on the hazard ratio of changing employment or relationship status.
Results
The clinical group had a higher hazard ratio of losing partner (hazard ratio 1.46, P < 0.001) and job (hazard ratio 4.18, P < 0.001) than the control group (corrected for age/gender). Compared with controls, clinical groups had a higher hazard of losing partner (affective group, hazard ratio 2.69, P = 0.003; psychotic group, hazard ratio 3.06, P = 0.001) and job (affective group, hazard ratio 3.43, P < 0.001; psychotic group, hazard ratio 4.11, P < 0.001). Adjusting for GAF, the hazard ratio of losing partner and job decreased in both clinical groups compared with controls.
Conclusion
Patients face an increased hazard of job loss and relationship dissolution compared with healthy controls, and this is partially conditioned by the diagnosis and functional level. These findings underscore a high demand for destigmatisation and support for individuals in managing their functional limitations.
Edited by
Randall Lesaffer, KU Leuven & Tilburg University,Anne Peters, Max Planck Institute for Comparative Public Law and International Law, Heidelberg
This chapter focuses on the recent (re)turn to history in scholarship of international relations (IR) on international law. We argue that two interrelated trends explain this development. The first is primarily internal to the field, where historically sensitive approaches have gained ground over the past thirty years. The second is external and the result of IR scholars’ productive engagement with debates in other fields, including global history, intellectual history and legal history. Although the new historical IR work on international law remains heavily indebted to histories produced outside the confines of the discipline, IR scholars at the vanguard of this movement are increasingly comfortable with writing histories themselves. New IR historical accounts have thus emerged, spanning broad subjects of international society, order and transformation, as well as specific areas of international law, including human rights, humanitarian law and international organisations. We review the history of the disciplinary divide between IR and legal history, outline how IR theoretical approaches have made use of history, highlight some of the thematic areas of the new IR historical work, and lay out possible future research directions.
In the mid-nineteenth century—even as many European liberals took a “turn to empire”—Mexican President Benito Juárez and his supporters enunciated an anti-imperial, liberal vision for international politics. In the context of the French intervention, Mexican liberals rejected claims that Europe’s material progress conferred upon the continent a “civilizing mission” vis-à-vis the rest of the world. Reconfiguring liberal and republican scripts, juaristas proposed an order legitimated by popular sovereignty and based on equality among states, non-intervention, and republican fraternity. This article situates juarista liberal internationalism in its historical context and in light of recent debates over liberalism’s longstanding entanglements with empire. By uncovering this overlooked strand of anti-imperial liberalism from the periphery, this article helps to decenter debates on liberal political thought and liberalism’s international implications. The juaristas’ rejoinder, we argue, should be integral to constructing a more pluralist and global understanding of the lineages of liberal internationalism.
Previous investigations of goethite revealed a substantial variation of color and diffuse reflectance spectra (DRS) in the extended visible range (350–2200 nm). To better understand the causes of this variability and to assess the potential of DRS as a mineralogical tool, we investigated the DRS of pure and Al-substituted goethite, α-Fe1−xAlxOOH with x from 0 to 0.33, and mean crystal lengths (MCL) from 170 to 1800 nm. The strongly overlapping ligand field bands were extracted by fitting the single-electron transitions 6A1 → 4T1, 6A1 → 4T2, 6A1 → (4E; 4A1), and 6A1 → 4E(4D) as functions of the ligand field splitting energy, 10 Dq, and the interelectronic repulsion parameters, Racah-B and -C. With x increasing from 0 to 0.33, 6A1 → 4T1 decreased from 10,590 to 10,150 cm−1 (944 to 958 nm), and 6A1 → 4T2 decreased from 15,310 to 14,880 cm−1 (653 to 672 nm), while 10 Dq increased from 15,770 to 16,220 cm−1. From the change of 10 Dq we calculated a decrease of the Fe-(O,OH) distances from 202.0 to 200.9 pm (−0.5%). This decrease is smaller than the average decrease of all (Al,Fe)-(O,OH) distances (−1.8%) calculated from the change of the unit-cell lengths (UCL). That is, there remains a substantial difference in size between the larger Fe- and the smaller Al-occupied octahedra in the solid solution which may indicate the existence of diaspore clusters within the goethite structure. The increasing strain in the crystal structure due to the size mismatch and limited contractibility of the oxygen cage around Fe may be the primary reason for Al substitution being restricted to x < 0.33. The bands 6A1 → (4E; 4A1) and 6A1 → 4E(4D) did not shift, indicating a constant covalency of the Fe-(O,OH) bonds with B = 628 cm−1 and C = 5.5B. Whereas variation of band energies could be explained in terms of the Fe-(O,OH) ligand field, the variation of color and band intensities was mainly determined by crystal size. Although our study confirmed the potential of DRS for mineralogical investigations, there is still a gap between the fundamental theory and the explanation of some spectral features.
Electronic measurement systems in the THz frequency range are often bulky and expensive devices. While some compact single-chip systems operating in the high millimeter-wave frequency range have recently been published, compact measurement systems in the low THz frequency range are still rare. The emergence of new silicon-germanium (SiGe) semiconductor technologies allow the integration of system components, like oscillators, frequency multipliers, frequency dividers, and antennas, operating in the low THz frequency range, into a compact monolithic microwave integrated circuits (MMIC), which contains most components to implement a low-cost and compact frequency-modulated continuous-wave-radar transceiver. This article presents a single transceiver solution containing all necessary components. It introduces a $0.48\,\mathrm{THz}$ radar transceiver MMIC with a tuning range of $43\,\mathrm{GHz}$ and an output power of up to $-9.4\,\mathrm{dBm}$ in the SG13G3 $130\,\mathrm{nm}$ SiGe technology by IHP. The MMIC is complemented by a dielectric lens antenna design consisting of polytetrafluoroethylene, providing up to $39.3\,\mathrm d\mathrm B\mathrm i$ of directivity and half-power beam widths of 0.95∘ in transmit and receive direction. The suppression of clutter from unwanted targets deviating from antenna boresight more than 6∘ is higher than $24.6\,\mathrm d \mathrm B$ in E- and H-Plane.
This study explores how the Academy Award for A Fantastic Woman facilitated the adoption of Chile's Gender Identity Law. Approved in 2018 after languishing for over five years in Congress, the law establishes individuals’ right to modify their national identification documents without the need to change their physical appearance or receive prior court authorisation. While trans rights activists extensively lobbied for a law that guaranteed access to gender marker changes, conservatives rejected the initiative, framing their opposition in terms of Christian values and against the ‘gender ideology’ that purportedly informed the bill. We argue that this backlash dissipated in the wake of the award. International recognition made support for trans rights temporarily a matter of national pride, thereby opening a window of opportunity for the approval of the law. The case of Chile's Gender Identity Law illustrates how international status cues can foster normative change by mobilising affect in domestic audiences. It contributes to recent debates on status and domestic political change, and the role that emotion and affect play in world politics.
Following up on a recent debate, we examined advice taking in dyads compared to individuals in a set of three studies (total N = 303 dyads and 194 individuals). Our first aim was to test the replicability of an important previous finding, namely that dyads heed advice less than individuals because they feel more confident in the accuracy of their initial judgments. Second, we aimed to explain dyads’ behavior based on three premises: first, that dyads understand that the added value of an outside opinion diminishes when the initial pre-advice judgment is made by two judges rather than one judge (given that the dyad members’ opinions are independent of each other); second, that they fail to recognize when the assumption of independence of opinions does not hold; and third, that the resistance to advice commonly observed in individuals persists in groups but is neither aggravated nor ameliorated by the group context. The results of our studies show consistently that previous findings on advice taking in dyads are replicable. They also support our hypothesis that groups exhibit a general tendency to heed advice less than individuals, irrespective of whether the accuracy of their initial judgments warrants this behavior. Finally, based on the three assumptions mentioned above, we were able to make accurate predictions about advice taking in dyads, prompting us to postulate a general model of advice taking in groups of arbitrary size.
Wind turbine towers are subjected to highly varying internal loads, characterized by large uncertainty. The uncertainty stems from many factors, including what the actual wind fields experienced over time will be, modeling uncertainties given the various operational states of the turbine with and without controller interaction, the influence of aerodynamic damping, and so forth. To monitor the true experienced loading and assess the fatigue, strain sensors can be installed at fatigue-critical locations on the turbine structure. A more cost-effective and practical solution is to predict the strain response of the structure based only on a number of acceleration measurements. In this contribution, an approach is followed where the dynamic strains in an existing onshore wind turbine tower are predicted using a Gaussian process latent force model. By employing this model, both the applied dynamic loading and strain response are estimated based on the acceleration data. The predicted dynamic strains are validated using strain gauges installed near the bottom of the tower. Fatigue is subsequently assessed by comparing the damage equivalent loads calculated with the predicted as opposed to the measured strains. The results confirm the usefulness of the method for continuous tracking of fatigue life consumption in onshore wind turbine towers.
International organizations come in many shapes and sizes. Within this institutional gamut, the multipurpose multilateral intergovernmental organization (MMIGO) plays a central role. This institutional form is often traced to the creation of the League of Nations, but in fact the first MMIGO emerged in the Western Hemisphere at the close of the nineteenth century. Originally modeled on a single-issue European public international union, the Commercial Bureau of the American Republics evolved into the multipurpose, multilateral Pan American Union (PAU). Contrary to prominent explanations of institutional genesis, the PAU's design did not result from functional needs nor from the blueprints of a hegemonic power. Advancing a recent synthesis between historical and rational institutionalism, we argue that the first MMIGO arose through a process of compensatory layering: a mechanism whereby a sequence of bargains over control and scope leads to gradual but transformative institutional change. We expect compensatory layering to occur when an organization is focal, power asymmetries among members of that organization are large, and preferences over institutional design diverge. Our empirical and theoretical contributions demonstrate the value a more global international relations (IR) perspective can bring to the study of institutional design. international relations (IR) scholars have long noted that international organizations provide smaller states with voice opportunities; our account suggests those spaces may be of smaller states’ own making.
Disruptive behavior disorders (DBD) are heterogeneous at the clinical and the biological level. Therefore, the aims were to dissect the heterogeneous neurodevelopmental deviations of the affective brain circuitry and provide an integration of these differences across modalities.
Methods
We combined two novel approaches. First, normative modeling to map deviations from the typical age-related pattern at the level of the individual of (i) activity during emotion matching and (ii) of anatomical images derived from DBD cases (n = 77) and controls (n = 52) aged 8–18 years from the EU-funded Aggressotype and MATRICS consortia. Second, linked independent component analysis to integrate subject-specific deviations from both modalities.
Results
While cases exhibited on average a higher activity than would be expected for their age during face processing in regions such as the amygdala when compared to controls these positive deviations were widespread at the individual level. A multimodal integration of all functional and anatomical deviations explained 23% of the variance in the clinical DBD phenotype. Most notably, the top marker, encompassing the default mode network (DMN) and subcortical regions such as the amygdala and the striatum, was related to aggression across the whole sample.
Conclusions
Overall increased age-related deviations in the amygdala in DBD suggest a maturational delay, which has to be further validated in future studies. Further, the integration of individual deviation patterns from multiple imaging modalities allowed to dissect some of the heterogeneity of DBD and identified the DMN, the striatum and the amygdala as neural signatures that were associated with aggression.
Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment.
Aims
To use a combination of transdiagnostic genetic and clinical factors to predict lithium response in patients with bipolar disorder.
Method
This study utilised genetic and clinical data (n = 1034) collected as part of the International Consortium on Lithium Genetics (ConLi+Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia and major depressive disorder, and then combined with clinical variables using a cross-validated machine-learning regression approach. Unimodal, multimodal and genetically stratified models were trained and validated using ridge, elastic net and random forest regression on 692 patients with bipolar disorder from ten study sites using leave-site-out cross-validation. All models were then tested on an independent test set of 342 patients. The best performing models were then tested in a classification framework.
Results
The best performing linear model explained 5.1% (P = 0.0001) of variance in lithium response and was composed of clinical variables, PRS variables and interaction terms between them. The best performing non-linear model used only clinical variables and explained 8.1% (P = 0.0001) of variance in lithium response. A priori genomic stratification improved non-linear model performance to 13.7% (P = 0.0001) and improved the binary classification of lithium response. This model stratified patients based on their meta-polygenic loadings for major depressive disorder and schizophrenia and was then trained using clinical data.
Conclusions
Using PRS to first stratify patients genetically and then train machine-learning models with clinical predictors led to large improvements in lithium response prediction. When used with other PRS and biological markers in the future this approach may help inform which patients are most likely to respond to lithium treatment.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus.
Aims
We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection.
Method
Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data.
Results
We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10−5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies.
Conclusions
We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing.
Methods
We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8–18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task.
Results
Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression.
Conclusions
Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment.
What strategies will states pursue in managing their relations with more powerful neighbours? International Relations scholarship identifies a wide range of policy options open to “secondary states,” including soft balancing, bandwagoning and institutional binding. We provide a conceptual framework to distinguish between these similar and often conflated institutional strategies on the basis of two dimensions: threat perception and inclusiveness. We then apply this framework to the inter-American system. Analyzing original data on treaty action between 1946 and 2015, we find that secondary states’ adherence to multilateral agreements increases when the United States participates and when states do not perceive the hegemon to be a threat. These findings suggest that institutional binding captures the dynamics of inter-American cooperation more adequately than either soft balancing or bandwagoning: states balance against perceived threats but bind their friends.
The aim of this study was to evaluate a case-mix system to classify inpatients with mental disorders in Germany by means of self-report and expert-rated instruments. The use of case-mix systems enhances the transparency of performance and cost structure and can thus improve the quality of mental health care. We analysed a consecutive sample of 1677 inpatients with mental disorders from 11 hospitals using regression tree analysis. The model assigns patients to 17 groups, accounting for 17% of the variance for duration of stay. Patients with eating disorders had a longer duration of stay than patients with anxiety disorder, duration of mental illness of less than 3–5 years, lower levels of interpersonal problems and higher occupational position. The results showed that besides diagnosis, variables such as duration of illness and interpersonal problems are important for classifying inpatients with mental disorders. The results of the study should be critically reviewed regarding the empirical results of other studies and the appropriateness of case group concepts for inpatients with mental disorders.