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7 results

  • Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine: Randomised controlled trial

  • Tony Kendrick, Robert Peveler, Louise Longworth, David Baldwin, Michael Moore, Judy Chatwin, Andrew Thornett, Jonathan Goddard, Michael Campbell, Helen Smith, Martin Buxton, Christopher Thompson
  • Journal:
    The British Journal of Psychiatry / Volume 188 / Issue 4 / April 2006
    Published online by Cambridge University Press:
    02 January 2018, pp. 337-345
    Print publication:
    April 2006
    • Article
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  • Background

    The cost-effectiveness of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) has not been compared in a prospective study in primary care.

    Aims

    To determine the relative cost-effectiveness of TCAs, SSRIs and lofepramine in UK primary care.

    Method

    An open-label, three-arm randomised trial with a preference arm. Practitioners referred 327 patients with incident depression.

    Results

    No significant differences were found in effectiveness or cost-effectiveness. The numbers of depression-free weeks over 12 months (on the Hospital Anxiety and Depression Scale) were 25.3 (95% CI 21.3–29.0) for TCAs, 28.3 (95% CI 24.3–32.2) for SSRIs and 24.6 (95% CI 20.6–28.9) for lofepramine. Mean health service costs per patient were $762 (95% CI 553–1059) for TCAs, $875 (95% CI 675–1355) for SSRIs and $867 (95% CI 634–1521) for lofepramine. Cost-effectiveness acceptability curves suggested SSRIs were most cost-effective (with a probability of up to 0.6).

    Conclusions

    The findings support a policy of recommending SSRIs as first-choice antidepressants in primary care.

  • Microscopy of Metal Oxide Surfaces

  • Martin R. Castell, Sergei L. Dudarev, Christiane Muggelberg, Adrian P. Sutton, G. Andrew D. Briggs, David T. Goddard
  • Journal:
    / Volume 6 / Issue 4 / July 2000
    Published online by Cambridge University Press:
    07 August 2002, pp. 324-328
    Print publication:
    July 2000

  • Elevated temperature scanning tunneling microscopy is used to study oxides that are room temperature insulators but become sufficiently electrically conducting at higher temperatures to allow imaging to be performed. Atomic resolution images of NiO, CoO, and UO2 have been obtained in this fashion which allow surface structure and defect determination. To complement the experiments, modeling of the electronic surface structure reveals which atomic sites give rise to the contrast observed in the images. Low voltage scanning electron microscopy is used to image small equilibrium pores in UO2 single crystals to evaluate the surface energy ratio of the (111) to (001) surfaces.