Models of insulin secretory vesicles from pancreatic beta cells have been created using the cellPACK suite of tools to research, curate, construct and visualise the current state of knowledge. The model integrates experimental information from proteomics, structural biology, cryoelectron microscopy and X-ray tomography, and is used to generate models of mature and immature vesicles. A new method was developed to generate a confidence score that reconciles inconsistencies between three available proteomes using expert annotations of cellular localisation. The models are used to simulate soft X-ray tomograms, allowing quantification of features that are observed in experimental tomograms, and in turn, allowing interpretation of X-ray tomograms at the molecular level.

In the Arctic, rapid climate change has kindled efforts to delineate and project the future of important habitats for marine birds and mammals. These animals are vital to subsistence economies and cultures, so including the needs of both animals and hunters in conservation planning is key to sustaining social-ecological systems. In the northeast Chukchi Sea, a nearshore corridor of open water is a major spring migration route for half a million eider ducks that are hunted along the landfast ice. Zoning areas for industrial activities or conservation should consider both eider habitat and hunter access to those habitats from the variable ice edge. Based on benthic sampling in 2010‒2012, a model of eider foraging energetics and satellite data on ice patterns in April and May 1997‒2011, we mapped the range of positions of the landfast ice edge relative to a given dispersion of habitat suitable for eider feeding. In some sectors, feeding areas were too limited or too far from landfast ice to provide regular hunting access. In other sectors, overlap of the ice edge with eider feeding habitat was quite variable, but often within a consistent geographic range. Areas accessible to hunters were a small fraction of total eider habitat, so areas adequate for conserving eiders would not necessarily include areas that meet the hunters’ needs. These results can inform spatial planning of industrial activities that yield cash income critical to subsistence hunting in less developed locations. Our study provides an approach for mapping ‘subsistence conservation areas’ throughout the Arctic and an example for such efforts elsewhere.

The “long 1950s,” once written off as a conservative era, now figure in many histories as the height of American “high modernity,” the apogee of a scientific outlook rooted in instrumental reason. This portrait suggests that the “Enlightenment project” took firm hold of American thought and culture in the early Cold War years, having finally defeated those who sought to yoke scientific rationality to one or another system of moral restraints. Despite nascent movements of opposition, the story goes, a rationalistic, technocratic form of liberalism dominated national life until the left and right mobilized against it in the 1960s.

This article offers a broad sketch of claims regarding the university’s public purpose in the 1960s while noting that a vision of the university as an autonomous forum for moral debate cut across the seemingly insurmountable divide between young radicals and their liberal elders. Read through the lens of educational philosophies, the era's clashes did not simply pit liberal advocates of political neutrality against radical exponents of political commitment. Rather, many radical activists—and some liberals— believed that the university should cut off many of its ties to the wider society to gain a more critical purchase on it. Indeed, critics of Clark Kerr's bureaucratic “multiversity” often hewed to a surprisingly traditional conception of higher education.